Genetic removal of synaptic Zn²⁺ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity.

Autor: Vogler, Emily C., Mahavongtrakul, Matthew, Sarkan, Kristianna, Bohannan, Ryan C., Catuara-Solarz, Silvina, Busciglio, Jorge

Publikováno v: Frontiers in Neurology; 1/20/2023, Vol. 14, p1-15, 15p

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

Autor: Chia, Ruth, Sabir, Marya S., Bandres-Ciga, Sara, Saez-Atienzar, Sara, Reynolds, Regina H., Gustavsson, Emil, Walton, Ronald L., Ahmed, Sarah, Viollet, Coralie, Ding, Jinhui, Makarious, Mary B., Diez-Fairen, Monica, Portley, Makayla K., Shah, Zalak, Abramzon, Yevgeniya, Hernandez, Dena G., Blauwendraat, Cornelis, Stone, David J., Eicher, John, Parkkinen, Laura, Ansorge, Olaf, Clark, Lorraine, Honig, Lawrence S., Marder, Karen, Lemstra, Afina, George-Hyslop, Peter St, Londos, Elisabet, Morgan, Kevin, Lashley, Tammaryn, Warner, Thomas T., Jaunmuktane, Zane, Galasko, Douglas, Santana, Isabel, Tienari, Pentti J., Myllykangas, Liisa, Oinas, Minna, Cairns, Nigel J., Morris, John C., Halliday, Glenda M., Van Deerlin, Vivianna M., Trojanowski, John Q., Grassano, Maurizio, Calvo, Andrea, Mora, Gabriele, Canosa, Antonio, Floris, Gianluca, Bohannan, Ryan C., Brett, Francesca, Gan-Or, Ziv, Geiger, Joshua T., Moore, Anni, May, Patrick, Krüger, Rejko, Goldstein, David, Lopez, Grisel, Tayebi, Nahid, Sidransky, Ellen, Palma, Jose-Alberto, Kaufmann, Horacio, Shakkottai, Vikram, Perkins, Matthew, Newell, Kathy L., Gasser, Thomas, Schulte, Claudia, Landi, Francesco, Salvi, Erika, Cusi, Daniele, Masliah, Eliezer, Kim, Ronald C., Caraway, Chad A., Monuki, Ed, Brunetti, Maura, Dawson, Ted M., Rosenthal, Liana S., Albert, Marilyn S., Pletnikova, Olga, Troncoso, Juan C., Flanagan, Margaret E., Mao, Qinwen, Bigio, Eileen H., Rodríguez-Rodríguez, Eloy, Infante, Jon, Lage, Carmen, González-Aramburu, Isabel, Sanchez-Juan, Pascual, Ghetti, Bernardino, Keith, Julia, Black, Sandra E., Masellis, Mario, Rogaeva, Ekaterina, Duyckaerts, Charles, Brice, Alexis, Lesage, Suzanne, Xiromerisiou, Georgia, Barrett, Matthew J., Tilley, Bension S., Gentleman, Steve, Logroscino, Giancarlo, Serrano, Geidy E., Beach, Thomas G., McKeith, Ian G., Thomas, Alan J., Attems, Johannes, Morris, Christopher M., Palmer, Laura, Love, Seth, Troakes, Claire, Al-Sarraj, Safa, Hodges, Angela K., Aarsland, Dag, Klein, Gregory, Kaiser, Scott M., Woltjer, Randy, Pastor, Pau, Bekris, Lynn M., Leverenz, James, Besser, Lilah M., Kuzma, Amanda, Renton, Alan E., Goate, Alison, Bennett, David A., Scherzer, Clemens R., Morris, Huw R., Ferrari, Raffaele, Albani, Diego, Brown, Stuart Pickering, Faber, Kelley, Kukull, Walter, Morenas-Rodriguez, Estrella, Lleó, Alberto, Fortea, Juan, Alcolea, Daniel, Clarimon, Jordi, Nalls, Michael A., Ferrucci, Luigi, Resnick, Susan M., Tanaka, Toshiko, Foroud, Tatiana M., Graff-Radford, Neill R., Wszolek, Zbigniew K., Ferman, Tanis, Boeve, Bradley F., Hardy, John A., Topol, Eric, Torkamani, Ali, Singleton, Andrew B., Ryten, Mina, Dickson, Dennis, Chiò, Adriano, Ross, Owen A., Gibbs, J. Raphael, Dalgard, Clifton L., Traynor, Bryan J., Scholz, Sonja W.

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia

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http://orbilu.uni.lu/handle/10993/44713

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Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.

Autor: Chia R; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Sabir MS; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Bandres-Ciga S; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Saez-Atienzar S; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Reynolds RH; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK., Gustavsson E; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK., Walton RL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ahmed S; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Viollet C; Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Ding J; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Makarious MB; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Diez-Fairen M; Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain., Portley MK; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Shah Z; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Abramzon Y; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK., Hernandez DG; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Blauwendraat C; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Stone DJ; Cerevel Therapeutics, Boston, MA, USA., Eicher J; Genetics and Pharmacogenomics, Merck & Co., Inc., West Point, PA, USA., Parkkinen L; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Ansorge O; Nuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK., Clark L; Taub Institute for Alzheimer Disease and the Aging Brain, and Department of Pathology and Cell Biology, Columbia University, New York, NY, USA., Honig LS; Taub Institute for Alzheimer Disease and the Aging Brain, G. H. Sergievsky Center and Department of Neurology, Columbia University, New York, NY, USA., Marder K; Taub Institute for Alzheimer Disease and the Aging Brain, G. H. Sergievsky Center and Department of Neurology, Columbia University, New York, NY, USA., Lemstra A; Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands., St George-Hyslop P; Department of Clinical Neurosciences, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Londos E; Clinical Memory Research Unit, Institution of Clinical Sciences Malmo, Lund University, Lund, Sweden., Morgan K; Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK., Lashley T; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Warner TT; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK.; Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Jaunmuktane Z; Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Galasko D; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA., Santana I; Neurology Service, University of Coimbra Hospital, Coimbra, Portugal.; Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal., Tienari PJ; Translational Immunology, Research Programs Unit, University of Helsinki, Helsinki, Finland.; Department of Neurology, Helsinki University Hospital, Helsinki, Finland., Myllykangas L; Department of Pathology, Medicum, University of Helsinki, Helsinki, Finland.; HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland., Oinas M; Department of Clinical Medicine, Faculty of Health, UiT The Arctic University of Norway, Tromsø, Norway., Cairns NJ; Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA., Morris JC; Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA., Halliday GM; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia., Van Deerlin VM; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grassano M; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy., Calvo A; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Mora G; Istituti Clinici Scientifici Maugeri, IRCCS, Milan, Italy., Canosa A; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Floris G; Department of Neurology, University Hospital of Cagliari, Cagliari, Italy., Bohannan RC; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA., Brett F; Dublin Brain Bank, Neuropathology Department, Beaumont Hospital, Dublin, Ireland., Gan-Or Z; Montreal Neurological Institute and Hospital, Department of Neurology & Neurosurgery, McGill University, Montreal, Quebec, Canada., Geiger JT; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Moore A; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., May P; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Krüger R; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg.; Parkinson Research Clinic, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Goldstein DS; Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Lopez G; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA., Tayebi N; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA., Sidransky E; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA., Norcliffe-Kaufmann L; Department of Neurology, New York University School of Medicine, New York, NY, USA., Palma JA; Department of Neurology, New York University School of Medicine, New York, NY, USA., Kaufmann H; Department of Neurology, New York University School of Medicine, New York, NY, USA., Shakkottai VG; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Perkins M; Michigan Brain Bank, University of Michigan Medical School, Ann Arbor, MI, USA., Newell KL; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Gasser T; Department of Neurodegenerative Diseases, Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases, Tübingen, Germany., Schulte C; Department of Neurodegenerative Diseases, Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen and German Center for Neurodegenerative Diseases, Tübingen, Germany., Landi F; Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore, Rome, Italy., Salvi E; Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Cusi D; Bio4Dreams-Business Nursery for Life, Milan, Italy., Masliah E; Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Kim RC; Department of Neuropathology, School of Medicine, University of California Irvine, Irvine, CA, USA., Caraway CA; Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA., Monuki ES; Department of Pathology & Laboratory Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA., Brunetti M; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy., Dawson TM; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.; Neuroregeneration and Stem Cell Programs, Institute of Cell Engineering, Johns Hopkins University Medical Center, Baltimore, MD, USA.; Department of Pharmacology and Molecular Science, Johns Hopkins University Medical Center, Baltimore, MD, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University Medical Center, Baltimore, MD, USA., Rosenthal LS; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Albert MS; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Pletnikova O; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.; Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Troncoso JC; Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA., Flanagan ME; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mao Q; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Bigio EH; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rodríguez-Rodríguez E; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Infante J; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Lage C; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., González-Aramburu I; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Sanchez-Juan P; Neurology Service, University Hospital Marqués de Valdecilla-IDIVAL-UC-CIBERNED, Santander, Spain., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Keith J; Department of Anatomical Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Black SE; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.; LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., Masellis M; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.; LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.; Cognitive & Movement Disorders Clinic, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Duyckaerts C; Department of Neuropathology Escourolle, Paris Brain Institute, Sorbonne Universités, Paris, France.; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital Pitié-Salpêtrière, DMU Neuroscience 6, Paris, France., Brice A; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital Pitié-Salpêtrière, DMU Neuroscience 6, Paris, France., Lesage S; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital Pitié-Salpêtrière, DMU Neuroscience 6, Paris, France., Xiromerisiou G; Department of Neurology, University Hospital of Larissa, University of Thessalia, Larissa, Greece., Barrett MJ; Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA., Tilley BS; Neuropathology Unit, Department of Brain Sciences, Imperial College London, London, UK., Gentleman S; Neuropathology Unit, Department of Brain Sciences, Imperial College London, London, UK., Logroscino G; Department of Basic Medicine Neurosciences and Sense Organs, University Aldo Moro, Bari, Italy.; Center for Neurodegenerative Diseases and the Aging Brain - Department of Clinical Research in Neurology of the University of Bari at 'Pia Fondazione Card G. Panico' Hospital Tricase (Le), Bari, Italy., Serrano GE; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., McKeith IG; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Thomas AJ; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Attems J; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Morris CM; Newcastle Brain Tissue Resource, Translational and Clinical Research Institute, Biomedical Research Building, Newcastle University, Newcastle upon Tyne, UK., Palmer L; South West Dementia Brain Bank, Bristol Medical School, University of Bristol, Bristol, UK., Love S; Dementia Research Group, Bristol Medical School, University of Bristol, Bristol, UK., Troakes C; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Al-Sarraj S; Department of Clinical Neuropathology and London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College Hospital and King's College London, London, UK., Hodges AK; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Aarsland D; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway., Klein G; Rush Alzheimer's Disease Center, Rush University, Chicago, IL, USA., Kaiser SM; Department of Neuropathology, Indiana University School of Medicine, Indianapolis, IN, USA., Woltjer R; Department of Neurology, Oregon Health & Sciences University, Portland, OR, USA., Pastor P; Memory and Movement Disorders Units, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain., Bekris LM; Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA., Leverenz JB; Cleveland Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA., Besser LM; Institute for Human Health and Disease Intervention, Florida Atlantic University, Boca Raton, FL, USA., Kuzma A; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Renton AE; Ronald M. Loeb Center for Alzheimer's Disease, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goate A; Ronald M. Loeb Center for Alzheimer's Disease, Nash Family Department of Neuroscience, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University, Chicago, IL, USA., Scherzer CR; Precision Neurology Program, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Morris HR; Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK., Ferrari R; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK., Albani D; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Faber K; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Kukull WA; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA, USA., Morenas-Rodriguez E; Biomedizinisches Centrum, Biochemie, Ludwig-Maximilians-Universität München & Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany.; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Lleó A; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Fortea J; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Alcolea D; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Clarimon J; Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; The Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Ferrucci L; Longitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA., Tanaka T; Longitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA., Foroud TM; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Ferman T; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Hardy JA; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute of UCL, UCL Institute of Neurology, University College London, London, UK.; UCL Movement Disorders Centre, University College London, London, UK.; Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Topol EJ; Scripps Research Translational Institute, Scripps Research, La Jolla, CA, USA., Torkamani A; Scripps Research Translational Institute, Scripps Research, La Jolla, CA, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA., Ryten M; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chiò A; Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.; Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.; Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy., Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Clinical Genomics, Mayo Clinic, Jacksonville, FL, USA., Gibbs JR; Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Traynor BJ; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, University College London, London, UK.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA., Scholz SW; Neurodegenerative Diseases Research Unit, Laboratory of Neurogenetics, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. sonja.scholz@nih.gov.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA. sonja.scholz@nih.gov.

Publikováno v: Nature genetics [Nat Genet] 2021 Mar; Vol. 53 (3), pp. 294-303. Date of Electronic Publication: 2021 Feb 15.