Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Boguslawa Sadowski"'
Autor:
Martin Meschkat, Anna M. Steyer, Marie-Theres Weil, Kathrin Kusch, Olaf Jahn, Lars Piepkorn, Paola Agüi-Gonzalez, Nhu Thi Ngoc Phan, Torben Ruhwedel, Boguslawa Sadowski, Silvio O. Rizzoli, Hauke B. Werner, Hannelore Ehrenreich, Klaus-Armin Nave, Wiebke Möbius
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance
Externí odkaz:
https://doaj.org/article/287e7feee643483fbef3a7725df08a2f
Autor:
Sarah Moyon, Rebecca Frawley, Damien Marechal, Dennis Huang, Katy L. H. Marshall-Phelps, Linde Kegel, Sunniva M. K. Bøstrand, Boguslawa Sadowski, Yong-Hui Jiang, David A. Lyons, Wiebke Möbius, Patrizia Casaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective
Externí odkaz:
https://doaj.org/article/0cc9b5962f0a40eabbf4462ab04b7567
Autor:
Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano, Lawrence R Shiow, Kevin W Kelley, Boguslawa Sadowski, Garrett Timmons, Anne-Katrin Pröbstel, Jackie N Wright, Jung Hyung Sin, Michael Devereux, Daniel E Morrison, Sandra M Chang, Khalida Sabeur, Ari J Green, Klaus-Armin Nave, Robin JM Franklin, David H Rowitch
Publikováno v:
eLife, Vol 7 (2018)
Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures and progressiv
Externí odkaz:
https://doaj.org/article/08a072ddc3c447a1bdecec41fc96cfc9
Autor:
Katy Lh Marshall-Phelps, Rebecca Frawley, Boguslawa Sadowski, Wiebke Möbius, Damien Marechal, Sunniva M. K. Bøstrand, Yong-hui Jiang, David A. Lyons, Patrizia Casaccia, Sarah Moyon, Dennis Huang, Linde Kegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, 2023, 12 (1), pp.3359. ⟨10.1038/s41467-021-23735-3⟩
Nature Communications
Nature Communications, 2023, 12 (1), pp.3359. ⟨10.1038/s41467-021-23735-3⟩
The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834bae069a8bb3aa4c9bab12bdb0efe0
https://doaj.org/article/0cc9b5962f0a40eabbf4462ab04b7567
https://doaj.org/article/0cc9b5962f0a40eabbf4462ab04b7567
α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease
Autor:
Anja Schneider, Tanja Kraus, Walter Maetzler, Boguslawa Sadowski, Brit Mollenhauer, Markus A. Hobert, Björn Zapke, Anne Stuendl, Madhurima Chatterjee, Kathrin Brockmann, Christian Deuschle, Wiebke Moebius
Publikováno v:
Movement disorders 36(11), 2508-2518 (2021). doi:10.1002/mds.28639
Background Extracellular vesicles are small vesicles that are released from many cells, including neurons. α-Synuclein has recently been described in extracellular vesicles derived from the central nervous system and may contribute to the spreading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1c89b184b53e44a642471ff45ac27b
Autor:
Hauke B. Werner, Hannelore Ehrenreich, Paola Agüi-Gonzalez, Olaf Jahn, Torben Ruhwedel, Lars Piepkorn, Anna M. Steyer, Klaus-Armin Nave, Silvio O. Rizzoli, Boguslawa Sadowski, Kathrin Kusch, Martin Meschkat, Nhu Thi Ngoc Phan, Wiebke Möbius, Marie-Theres Weil
SummaryMyelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. This raises the question how myelin function is affected by myelin turnover. We have studied the integrity of myelinated tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fce24448ad777f676e696ad6f9529d75
https://doi.org/10.1101/2020.09.02.279612
https://doi.org/10.1101/2020.09.02.279612
Autor:
Wiebke Möbius, Daryna Tarasenko, Daniel C. Jans, Mariam Barbot, Michael Meinecke, Stefan Jakobs, Benjamin Kroppen, Boguslawa Sadowski, Gudrun Heim
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology
The multisubunit mitochondrial contact site and cristae organizing system (MICOS) plays an important role in cristae junction formation. Tarasenko et al. show that the MICOS component Mic60 actively bends membranes and that this activity is evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108434dc9b6f5abf65b631c6e7a2c60b
http://europepmc.org/articles/PMC5379949
http://europepmc.org/articles/PMC5379949
Autor:
Katy Lh Marshall-Phelps, Sarah Moyon, Boguslawa Sadowski, Patrizia Casaccia, Linde Kegel, Sunniva M. K. Bøstrand, Rebecca Frawley, Dennis Huang, Yong-hui Jiang, David A. Lyons, Wiebke Möbius
Adult myelination is essential for brain function and response to injury, but the molecular mechanisms remain elusive. Here we identify DNA hydroxy-methylation, an epigenetic mark catalyzed by Ten-Eleven translocation (TET) enzymes, as necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78d5f5321b23b454410465bf6d761ac
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1936
In this chapter, we describe protocols to study different aspects of oligodendrocytes and myelin using electron microscopy. First, we describe in detail how to prepare central nervous system tissue routinely by perfusion fixation of the animal and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04948ea06a59175e13936afd91d4cdb4
https://pubmed.ncbi.nlm.nih.gov/30820909
https://pubmed.ncbi.nlm.nih.gov/30820909
Publikováno v:
Oligodendrocytes ISBN: 9781493990702
In this chapter, we describe protocols to study different aspects of oligodendrocytes and myelin using electron microscopy. First, we describe in detail how to prepare central nervous system tissue routinely by perfusion fixation of the animal and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d37fd1a30c8389afda853b884a082a0
https://doi.org/10.1007/978-1-4939-9072-6_20
https://doi.org/10.1007/978-1-4939-9072-6_20