Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Boguslaw Mudryk"'
Autor:
John R. Coombs, Jason Zhu, Francisco González-Bobes, Sanjeewa Rupasinghe, Kishta Katipally, Boguslaw Mudryk, William P. Gallagher, Carlos A. Guerrero, Candice L. Joe
Publikováno v:
Organic Process Research & Development. 26:583-591
The cyclohexyl fragment 1 in BMS-986251 was synthesized starting from Hagemann’s ester 2 in 7 steps and 5 isolations. The route is highlighted by a dynamic kinetic resolution (DKR), a telescoped en...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ea0653ff5238432d57a80b901be60b
https://doi.org/10.1021/acs.oprd.1c00339
https://doi.org/10.1021/acs.oprd.1c00339
Autor:
John R. Coombs, Francisco González-Bobes, Boguslaw Mudryk, Arun Vinodini, Sankar Kuppusamy, Candice L. Joe, Senthil Palani, Muthukrishnan Ponnusamy, Vedhachalam Nagappan, Rajappa Vaidyanathan, William P. Gallagher, Aravind S. Gangu, Martin D. Eastgate, Sanjeewa Rupasinghe, Alla Venu, Nathaniel Kopp, Srinivas Kalidindi, Shankar Tendulkar
Publikováno v:
Organic Process Research & Development. 25:1547-1555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5d45a55c301e242d68690ce145b08c
https://doi.org/10.1021/acs.oprd.1c00124
https://doi.org/10.1021/acs.oprd.1c00124
Publikováno v:
Organic Process Research & Development. 22:1534-1540
The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and afforded desired 1 in eight chemical transformations. The key step involved formation of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ad5f3dd5ed95704fd2d8721eee4ae5
https://doi.org/10.1021/acs.oprd.8b00307
https://doi.org/10.1021/acs.oprd.8b00307
Autor:
Thomas M. Razler, Jianji Wang, Yi Hsiao, Yuping Qiu, Thorsten Rosner, Kolotuchin Sergei, Carolyn S. Wei, Carrasquillo Ronald, Andrew G. Lee, Brendan Mack, Paul C. Lobben, Jacob M. Janey, Zhongping Shi, Eric M. Simmons, Jason M. Stevens, Xinhua Qian, Eric C. Huang, Federico Lora-Gonzalez, Thomas La Porte, Steven R. Wisniewski, Geng Peng, Gregory L. Beutner, Boguslaw Mudryk, Kishta Katipally, Ye Zhu, Antonio Ramirez
Publikováno v:
Organic Letters. 20:3736-3740
A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b68020a70953f67cf64673382d9733e
https://doi.org/10.1021/acs.orglett.8b01218
https://doi.org/10.1021/acs.orglett.8b01218
Publikováno v:
Organic Process Research & Development. 21:1659-1667
The development of a scalable process for the Rh-catalyzed asymmetric 1,4-addition of (isopropenyl)pinacolboronate to 2-cyclohexen-1-one is reported. High-throughput ligand screening and initial optimization studies identified DTBM-SEGPHOS as an effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d81c6f62720517a1425e25ea53b69aea
https://doi.org/10.1021/acs.oprd.7b00253
https://doi.org/10.1021/acs.oprd.7b00253
Autor:
Boguslaw Mudryk, Martin D. Eastgate, Saravanababu Murugesan, Michael S. Bultman, Matthew R. Hickey, Francisco González-Bobes, Benjamin M. Cohen, David A. Conlon, Richard L. Schild, Fanfair Dayne Dustan, Victor W. Rosso, Ke Chen, Ivy Sabrina E, Neil A. Strotman, Jason T. Sweeney
Publikováno v:
Organic Process Research & Development. 21:1137-1144
We report research focused on the preparation of an advanced intermediate in the synthesis of a novel antiretroviral. This manuscript describes the development of an efficient oxidation of a 6-azaindole derivative, the bromination of the resulting N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f59e16057524f73bf3b586447c44860
https://doi.org/10.1021/acs.oprd.7b00132
https://doi.org/10.1021/acs.oprd.7b00132
Autor:
James H. Simpson, Michelle Soltani, Yi Hsiao, Bin Zheng, Michael S. Bultman, Christina Ann Risatti, Maxime Soumeillant, David A. Conlon, Martin D. Eastgate, Boguslaw Mudryk, Thomas E. La Cruz, Ke Chen, Tripp Jonathan Clive
Publikováno v:
Organic Process Research & Development. 21:1110-1121
During the process of developing a synthesis to a complex molecule, multiple decisions are made regarding the strategies and tactics used to prepare key bonds. In this article, we preface a series of papers describing the development of the commercia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31387c1bc43af9d8971ca3690ef364db
https://doi.org/10.1021/acs.oprd.7b00121
https://doi.org/10.1021/acs.oprd.7b00121
Autor:
Schultz Mitchell J, Payack Joseph Francis, Thomas E. La Cruz, Deniz Erdemir, Peng Geng, Sévrine Broxer, Ivy Sabrina E, Chung-Pin H. Chen, David A. Conlon, Zhongmin Xu, Saravanababu Murugesan, Fanfair Dayne Dustan, Fritz Alan W, Ryan Cullen, Tripp Jonathan Clive, Boguslaw Mudryk, Wendel W. Doubleday, Richard J. Fox
Publikováno v:
Organic Process Research & Development. 21:1095-1109
The development of two enabling routes that led to the production of >1000 kg of BMS-663068 (3) is described. The route identified for the initial 100 kg delivery to support development activities and initial clinical trials involved the conversion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c87b27b11fba74bca85d3614705da09
https://doi.org/10.1021/acs.oprd.7b00134
https://doi.org/10.1021/acs.oprd.7b00134
Autor:
Boguslaw Mudryk, Adrian Ortiz, Zhongping Shi, James R. Sawyer, David A. Conlon, David R. Kronenthal, Bin Zheng, Masano Sugiyama, Ian S. Young, R. Michael Corbett, Amit Joshi, Jale Muslehiddinoglu
Publikováno v:
Synlett. 24:305-312
An efficient synthetic route to the potent and selective ErbB VEGF receptor inhibitor, BMS-690514 ( 1 ) is described. Strategic modifications in both approach and procedure addressed several issues, which led to a safe, efficient, and economical proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::246b3cef3de6de011e6f199343bd6e72
https://doi.org/10.1055/s-0032-1317540
https://doi.org/10.1055/s-0032-1317540
Autor:
Alan Braem, Justin L. Burt, Antonio Ramirez, Boguslaw Mudryk, Srinivas Tummala, Rossano Lucius T
Publikováno v:
Journal of Pharmaceutical Innovation. 6:181-192
This case study outlines an application of quality by design principles to a drug substance manufacturing process. A hybrid process chemistry model consisting of mechanistic and empirical components was developed to guide the selection and verificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::623e0441be5d3206e15508a9b085733d
https://doi.org/10.1007/s12247-011-9109-3
https://doi.org/10.1007/s12247-011-9109-3