Zobrazeno 1 - 10
of 519
pro vyhledávání: '"Bogusław Okopień"'
Publikováno v:
International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 22, Iss , Pp 200297- (2024)
Lipoprotein(a) is a recognized risk factor for ASCVD. There is still no targeted therapy for Lp(a), however, drugs such as pelacarsen, olpasiran, zerlasiran, lepodisiran and muvalaplin are in clinical trials and have been shown to be effective in sig
Externí odkaz:
https://doaj.org/article/6c3d15e4affa451c9d73960592c73207
Autor:
Michał Nicze, Adrianna Dec, Maciej Borówka, Damian Krzyżak, Aleksandra Bołdys, Łukasz Bułdak, Bogusław Okopień
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8202 (2024)
Obesity is a chronic disease caused primarily by the imbalance between the amount of calories supplied to the body and energy expenditure. Not only does it deteriorate the quality of life, but most importantly it increases the risk of cardiovascular
Externí odkaz:
https://doaj.org/article/90fe9c09b1524f32b0313142bd8493f3
Publikováno v:
Life, Vol 14, Iss 6, p 690 (2024)
Cardiovascular disease (CVD) remains a prominent cause of global mortality, primarily driven by atherosclerosis. Diabetes mellitus, as a modifiable risk factor, significantly contributes to atherogenesis. Monocyte recruitment to the intima is a criti
Externí odkaz:
https://doaj.org/article/1b076d0f8d454f1a87263b7af9d9b797
Publikováno v:
Medicina, Vol 60, Iss 6, p 908 (2024)
Background and Objectives: The rise in global diabetes cases, reaching a staggering 529 million in 2021 from 108 million in 1980, underscores the urgency of addressing its complications, notably macrovascular ones like coronary artery, cerebrovascula
Externí odkaz:
https://doaj.org/article/8a80b7f07dfa4ea4a1a3c3d736285c91
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1854 (2024)
Atherosclerosis stands out as one of the leading causes of global mortality. The inflammatory response against vascular wall components plays a pivotal role in the atherogenic process. The initiation of this process is notably driven by oxidized low-
Externí odkaz:
https://doaj.org/article/19d03850751045369169582b6e484471
Autor:
Agnieszka Polak, Grzegorz Machnik, Łukasz Bułdak, Jarosław Ruczyński, Katarzyna Prochera, Oliwia Bujak, Piotr Mucha, Piotr Rekowski, Bogusław Okopień
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1463 (2024)
Proprotein convertase subtilisin/kexin 9 (PCSK9) is a protein that plays a key role in the metabolism of low-density lipoprotein (LDL) cholesterol. The gain-of-function mutations of the PCSK9 gene lead to a reduced number of surface LDL receptors by
Externí odkaz:
https://doaj.org/article/05ecf1f8957741d68f801333c6bdec69
Autor:
Michał Nicze, Maciej Borówka, Adrianna Dec, Aleksandra Niemiec, Łukasz Bułdak, Bogusław Okopień
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 815 (2024)
Drugs based on peptides and proteins (PPs) have been widely used in medicine, beginning with insulin therapy in patients with diabetes mellitus over a century ago. Although the oral route of drug administration is the preferred one by the vast majori
Externí odkaz:
https://doaj.org/article/cfe73c202c8440c6a78171f1efb59727
Publikováno v:
Medicina, Vol 59, Iss 10, p 1789 (2023)
Metabolic-associated Fatty Liver Disease is one of the outstanding challenges in gastroenterology. The increasing incidence of the disease is undoubtedly connected with the ongoing obesity pandemic. The lack of specific symptoms in the early phases a
Externí odkaz:
https://doaj.org/article/fe71e01b444b4bee94bb5ae7d12196f2
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1190 (2023)
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) is associated with the excessive collection of lipids in hepatocytes. Over 75% of diabetes patients typically have MASLD, and, at the same time, the presence of MASLD increases the risk
Externí odkaz:
https://doaj.org/article/11ebbde621204d7eabc2a77a984e59bc
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 17, p 5474 (2023)
The effect of metformin on prolactin concentration seems to be sex-dependent. The aim of this study was to determine whether the androgen status modulates the impact of metformin on plasma prolactin levels in women. This study included two matched gr
Externí odkaz:
https://doaj.org/article/0c7663df651d45cb91822423115f2413