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Disruptive lysosomal-metabolic signaling and neurodevelopmental deficits that precede Purkinje cell loss in a mouse model of Niemann-Pick Type-C disease.

Autor: Kim S; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Ochoa K; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Melli SE; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Yousufzai FAK; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Barrera ZD; Department of Biological Science, Rowan University, Glassboro, NJ, USA., Williams AA; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ, USA., McIntyre G; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Delgado E; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Bolish JN; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ, USA., Macleod CM; Department of Biology, Providence College, Providence, RI, USA., Boghos M; Department of Biology, Providence College, Providence, RI, USA., Lens HP; Department of Biology, Providence College, Providence, RI, USA., Ramos AG; Department of Biology, Providence College, Providence, RI, USA., Wilson VB; Department of Biological Science, Rowan University, Glassboro, NJ, USA., Maloney K; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Padron ZM; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Khan AH; Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ, USA., Blanco RE; The Institute of Neurobiology, University of Puerto Rico, San Juan, PR, USA., Soto I; Department of Biology, Providence College, Providence, RI, USA. isotorey@providence.edu.

Publikováno v: Scientific reports [Sci Rep] 2023 Apr 06; Vol. 13 (1), pp. 5665. Date of Electronic Publication: 2023 Apr 06.