Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Boggs Sharon Davis"'
Autor:
John G. Catalano, Andrew Spaltenstein, Kristjan S. Gudmundsson, Michael Thomson, Pat Wheelan, Stephen Jenkinson, Boggs Sharon Davis, Angilique Svolto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6399-6403
Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27522821a2e22968456306898b1442dd
https://doi.org/10.1016/j.bmcl.2009.09.056
https://doi.org/10.1016/j.bmcl.2009.09.056
Autor:
Boggs Sharon Davis, Matthew J. Sharp, Kristjan S. Gudmundsson, Michael Tolar Martin, Vassil I. Elitzin
Publikováno v:
Organic Process Research & Development. 13:781-785
An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a7d8b53e51228cdb290f9a64bc2e9d
https://doi.org/10.1021/op9000675
https://doi.org/10.1021/op9000675
Autor:
Kristjan S. Gudmundsson, Mark D. Trone, Boggs Sharon Davis, Richard T. Matsuoka, Shiping Xie,‡ and, Xiaoming Zhou, Vicente Samano, Daniel E. Patterson, Lynda A. Jones, Alan Millar, Jeremy D. Cobb
Publikováno v:
Organic Process Research & Development. 11:539-545
An efficient asymmetric synthesis of N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide 1, a potential treatment for human papillomavirus infections, is described. The key step in the synthesis of this molecule is an asymmetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71441076ee72c0a2ed81b9764640ea79
https://doi.org/10.1021/op060223v
https://doi.org/10.1021/op060223v
Autor:
Millard H. Lambert, Randy K. Bledsoe, Boggs Sharon Davis, Jason Nichols, Shawn P. Williams, John T. Moore, Jon L. Collins, Timothy M. Willson, Ann B. Miller, David D. McKee, Michael A. Watson, Derek J. Parks, Linda B. Moore, Bruce Wisely
Publikováno v:
Journal of Biological Chemistry. 278:27138-27143
The x-ray crystal structures of the human liver X receptor β ligand binding domain complexed to sterol and nonsterol agonists revealed a perpendicular histidinetryptophan switch that holds the receptor in its active conformation. Hydrogen bonding in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b805b51c3cf75b118fcd22e4f6f97c8
https://doi.org/10.1074/jbc.m302260200
https://doi.org/10.1074/jbc.m302260200
Autor:
Istvan Kaldor, Boggs Sharon Davis, David N. Deaton, Katrina L. Creech, Lihong Chen, Justin A. Caravella, Terrence L. Smalley, Derek J. Parks
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(2)
The farnesoid X receptor (FXR) may play a crucial role in a number of metabolic diseases and, as such, could potentially serve as a target for the development of therapeutics as a treatment for those diseases. Previous work has described GW4064 as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6e7cae41f68722f8c3a66df31da559
https://pubmed.ncbi.nlm.nih.gov/25499883
https://pubmed.ncbi.nlm.nih.gov/25499883
Autor:
Yu Guo, Scott Howard Dickerson, Jeff Gobel, Dan Gillie, Lee T. Schaller, J. Patrick Condreay, Stephen A. Thomson, Boggs Sharon Davis, Curt D. Haffner
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(23)
We report the synthesis and in vitro activity of a series of novel N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several compounds, including compound 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a870ef7f27f641a6b9a4e61ecee832f9
https://pubmed.ncbi.nlm.nih.gov/20971642
https://pubmed.ncbi.nlm.nih.gov/20971642
Autor:
Sebahar Paul Richard, Boggs Sharon Davis, Kelly R. Moniri, Kevin W. Brown, Robert J. Harvey, Phiroze Sethna, Kristjan S. Gudmundsson, Karen Rene Romines, Andrew Spaltenstein, Richardson Leah D Aurora, Pamela L. Golden
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Synthesis of a series of tetrahydrocarbazole amides with potent activity against human papillomaviruses is described. Synthetic approaches allowing for variation of the substitution pattern of the tetrahydrocarbazole and the amide are outlined and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744bc06976ce2ab011c7dfb2d0e86a0b
https://pubmed.ncbi.nlm.nih.gov/19556128
https://pubmed.ncbi.nlm.nih.gov/19556128
Autor:
Sebahar Paul Richard, Boggs Sharon Davis, Robert J. Harvey, Kevin W. Brown, Kristjan S. Gudmundsson, Andrew Spaltenstein, Karen Rene Romines, Richardson Leah D Aurora, Phiroze Sethna, John G. Catalano
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(13)
The synthesis and SAR of a series of substituted 1-aminotetrahydrocarbazoles with potent activity against human papillomaviruses are described. Synthetic approaches allowing for variation of the substitution pattern of the tetrahydrocarbazole are out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24eff57c3e259dd3ba8c8fa94843d76e
https://pubmed.ncbi.nlm.nih.gov/19457669
https://pubmed.ncbi.nlm.nih.gov/19457669