Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Bogdan I Florea"'
Autor:
Muhammad Riaz, Yotam Raz, Maaike van Putten, Guillem Paniagua-Soriano, Yvonne D Krom, Bogdan I Florea, Vered Raz
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006031 (2016)
Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (O
Externí odkaz:
https://doaj.org/article/b01454b12f4f489ca125969f4059760f
Autor:
Wiebke Sachs, Lukas Blume, Desiree Loreth, Lisa Schebsdat, Favian Hatje, Sybille Koehler, Uta Wedekind, Marlies Sachs, Stephanie Zieliniski, Johannes Brand, Christian Conze, Bogdan I. Florea, Frank Heppner, Elke Krüger, Markus M. Rinschen, Oliver Kretz, Roland Thünauer, Catherine Meyer-Schwesinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Kidney filtration is ensured by the interaction of podocytes, endothelial and mesangial cells. Immunoglobulin accumulation at the filtration barrier is pathognomonic for glomerular injury. The mechanisms that regulate filter permeability are
Externí odkaz:
https://doaj.org/article/a86ad01a59e145d98cbb69c803c6d0ee
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Felix A. Trogisch, Franziska Koser, Synje Michel, David A. Liem, Bogdan I. Florea, Markus Hecker, Oliver Drews
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have demonstrated that increasing abund
Externí odkaz:
https://doaj.org/article/b394b1c743274c74866ccda3685ce473
Autor:
Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Little is known about the mechanistic significance of the ubiquitin proteasome system (UPS) in a kidney autoimmune environment. In membranous nephropathy (MN), autoantibodies target podocytes of the glomerular filter resulting in proteinuria
Externí odkaz:
https://doaj.org/article/cee0c8ae32e746e8ba523351dc7de044
Autor:
Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2ddf8a9a90b44a33b9442749e01f62a3
Autor:
Tom van der Wel, Riet Hilhorst, Hans den Dulk, Tim van den Hooven, Nienke M. Prins, Joost A. P. M. Wijnakker, Bogdan I. Florea, Eelke B. Lenselink, Gerard J. P. van Westen, Rob Ruijtenbeek, Herman S. Overkleeft, Allard Kaptein, Tjeerd Barf, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Chemical tools to monitor drug-target engagement of endogenous enzymes are essential for preclinical target validation. Here, the authors present a chemical genetics strategy to study target engagement of endogenous kinases, achieving specific labeli
Externí odkaz:
https://doaj.org/article/749ac4b664044b4d9100599885c8e063
Autor:
Roy Pattipeiluhu, Stefan Crielaard, Iris Klein-Schiphorst, Bogdan I. Florea, Alexander Kros, Frederick Campbell
Publikováno v:
ACS Central Science, Vol 6, Iss 4, Pp 535-545 (2020)
Externí odkaz:
https://doaj.org/article/93b1a2e28ba0483d8abc0cdd345c9b29
Autor:
Sebastiaan T. A. Koenders, Lukas S. Wijaya, Martje N. Erkelens, Alexander T. Bakker, Vera E. van der Noord, Eva J. van Rooden, Lindsey Burggraaff, Pasquale C. Putter, Else Botter, Kim Wals, Hans van den Elst, Hans den Dulk, Bogdan I. Florea, Bob van de Water, Gerard J. P. van Westen, Reina E. Mebius, Herman S. Overkleeft, Sylvia E. Le Dévédec, Mario van der Stelt
Publikováno v:
ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
Externí odkaz:
https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017
Autor:
Dr. Mattia Moiola, Dr. Antonio Bova, Dr. Stefano Crespi, Dr. Misal G. Memeo, Prof. Mariella Mella, Prof. Herman S. Overkleeft, Dr. Bogdan I. Florea, Prof. Paolo Quadrelli
Publikováno v:
ChemistryOpen, Vol 8, Iss 6, Pp 770-780 (2019)
Abstract Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond. The intr
Externí odkaz:
https://doaj.org/article/eaae9e8dc30346c3ad3d98857a076d77