Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Bogdan Budnik"'
Autor:
Zohreh Izadifar, Justin Cotton, Siyu Chen, Viktor Horvath, Anna Stejskalova, Aakanksha Gulati, Nina T. LoGrande, Bogdan Budnik, Sanjid Shahriar, Erin R. Doherty, Yixuan Xie, Tania To, Sarah E. Gilpin, Adama M. Sesay, Girija Goyal, Carlito B. Lebrilla, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Modulation of the cervix by steroid hormones and commensal microbiome play a central role in the health of the female reproductive tract. Here we describe organ-on-a-chip (Organ Chip) models that recreate the human cervical epithelial-stroma
Externí odkaz:
https://doaj.org/article/0c123d582c57457d8c8042d389f2b87d
Novel proteomics-based plasma test for early detection of multiple cancers in the general population
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective Early detection of cancer is crucial for reducing the global burden of cancer, but effective screening tests for many cancers do not exist. This study aimed to develop a novel proteome-based multi-cancer screening test that can detect early
Externí odkaz:
https://doaj.org/article/564977548efe43148e57e08d8e7a5fda
Autor:
Madison L. Sangster, Martha M. Bishop, Yizheng Yao, Jessica F. Feitor, Sanjid Shahriar, Maxwell E. Miller, Anil K. Chekuri, Bogdan Budnik, Fengfeng Bei, Yulia Grishchuk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101269- (2024)
Mucolipidosis IV (MLIV) is a rare, autosomal recessive, lysosomal disease characterized by intellectual disability, motor deficits, and progressive vision loss. Using adeno-associated vector 9 (AAV9) and AAV-PHP.B as delivery vectors, we previously d
Externí odkaz:
https://doaj.org/article/e7cd057cd76f4b5bae5aa926b9586f15
Publikováno v:
Advances in Biomarker Sciences and Technology, Vol 6, Iss , Pp 226- (2024)
Externí odkaz:
https://doaj.org/article/f62bc02b14d54e37afa9d88b505ddf0c
Autor:
Madison Sangster, Sanjid Shahriar, Zachary Niziolek, Maria Carla Carisi, Michael Lewandowski, Bogdan Budnik, Yulia Grishchuk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Mucolipidosis IV (MLIV) is an ultra-rare, recessively inherited lysosomal disorder resulting from inactivating mutations in MCOLN1, the gene encoding the lysosomal cation channel TRPML1. The disease primarily affects the central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/1273565b6a844f56b8aaccfa74f9fe3e
Autor:
Dmitry Ter-Ovanesyan, Tal Gilboa, Bogdan Budnik, Adele Nikitina, Sara Whiteman, Roey Lazarovits, Wendy Trieu, David Kalish, George M Church, David R Walt
Publikováno v:
eLife, Vol 12 (2023)
Extracellular vesicles (EVs) are released by all cells into biofluids such as plasma. The separation of EVs from highly abundant free proteins and similarly sized lipoproteins remains technically challenging. We developed a digital ELISA assay based
Externí odkaz:
https://doaj.org/article/b79a498ad03b4872840fae9f06fc5f4b
Autor:
Patrick R van den Berg, Noémie M L P Bérenger-Currias, Bogdan Budnik, Nikolai Slavov, Stefan Semrau
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010744 (2023)
Stem cell differentiation is a highly dynamic process involving pervasive changes in gene expression. The large majority of existing studies has characterized differentiation at the level of individual molecular profiles, such as the transcriptome or
Externí odkaz:
https://doaj.org/article/78b763b01884432f92e0513300c07938
Autor:
Seyedehmahsa Moghimi, Ekaterina G Viktorova, Samuel Gabaglio, Anna Zimina, Bogdan Budnik, Bridge G Wynn, Elizabeth Sztul, George A Belov
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010906 (2022)
As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication. Yet, our understanding of the complex ensembles of pro
Externí odkaz:
https://doaj.org/article/68f4c8fd44274518b03c46034f0752ba
Autor:
Juan A. Martínez‐Greene, Karina Hernández‐Ortega, Ricardo Quiroz‐Baez, Osbaldo Resendis‐Antonio, Israel Pichardo‐Casas, David A. Sinclair, Bogdan Budnik, Alfredo Hidalgo‐Miranda, Eileen Uribe‐Querol, María del Pilar Ramos‐Godínez, Eduardo Martínez‐Martínez
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract The molecular characterization of extracellular vesicles (EVs) has revealed a great heterogeneity in their composition at a cellular and tissue level. Current isolation methods fail to efficiently separate EV subtypes for proteomic and funct
Externí odkaz:
https://doaj.org/article/3fea4ede75eb44de885b00ed1907077e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
The protozoan parasite Trichomonas vaginalis (TV), exclusively adapted to the human genital tract, is one of the most common sexually transmitted pathogens. Adding to the complexity of the host-pathogen interactions, the parasite harbors TV-specific
Externí odkaz:
https://doaj.org/article/8a82ea1d630344cd9b0937afb9b53172