Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bogdan A. Zagribelnyy"'
Autor:
Andrey A. Ivashchenko, Bogdan A. Zagribelnyy, Yan A. Ivanenkov, Ilya A. Ivashchenko, Ruben N. Karapetian, Dmitry V. Kravchenko, Nikolay P. Savchuk, Elena V. Yakubova, Alexandre V. Ivachtchenko
Publikováno v:
Molecules, Vol 27, Iss 15, p 4975 (2022)
The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing
Externí odkaz:
https://doaj.org/article/ccf7c0d76b51471eb97df4d970b00559
Autor:
Yan A. Ivanenkov, Alex Zhavoronkov, Renat S. Yamidanov, Ilya A. Osterman, Petr V. Sergiev, Vladimir A. Aladinskiy, Anastasia V. Aladinskaya, Victor A. Terentiev, Mark S. Veselov, Andrey A. Ayginin, Victor G. Kartsev, Dmitry A. Skvortsov, Alexey V. Chemeris, Alexey Kh. Baimiev, Alina A. Sofronova, Alexander S. Malyshev, Gleb I. Filkov, Dmitry S. Bezrukov, Bogdan A. Zagribelnyy, Evgeny O. Putin, Maria M. Puchinina, Olga A. Dontsova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Many pharmaceutical companies are avoiding the development of novel antibacterials due to a range of rational reasons and the high risk of failure. However, there is an urgent need for novel antibiotics especially against resistant bacterial strains.
Externí odkaz:
https://doaj.org/article/8c16a1d4d0ea467faf6fd76819573bdc
Autor:
Vladimir A. Aladinskiy, Rostislav A Petrov, Yan A. Ivanenkov, Mark S. Veselov, Andrey A Ayginin, Alexey Kh Baimiev, Maria M Puchinina, Marina A Maximova, Anastasia V. Aladinskaya, Dmitry A. Skvortsov, Kseniya Yu Shvetc, Yulia V. Vakhitova, Alina A. Sofronova, Ilya A. Osterman, Andrey Kh Baimiev, Zulfiya R Zileeva, Katerina S Komarova, Dmitry S. Bezrukov, L. F. Zainullina, Victor A Terentiev, Bogdan A Zagribelnyy, Petr V. Sergiev, Alexey E. Machulkin, Renat S. Yamidanov, Olga A. Dontsova
Publikováno v:
Current Drug Discovery Technologies. 17:716-724
Background: The key issue in the development of novel antimicrobials is a rapid expansion of new bacterial strains resistant to current antibiotics. Indeed, World Health Organization has reported that bacteria commonly causing infections in hospitals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a9cc3c7142a75575f2c9fc022e9cc1
https://doi.org/10.2174/1570163816666190603095521
https://doi.org/10.2174/1570163816666190603095521
Publikováno v:
Journal of Medicinal Chemistry. 62:10026-10043
The paradigm of "drug-like-ness" dramatically altered the behavior of the medicinal chemistry community for a long time. In recent years, scientists have empirically found a significant increase in key properties of drugs that have moved structures c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1019747b08a33a2dfa3c75f7fac047d
https://doi.org/10.1021/acs.jmedchem.9b00004
https://doi.org/10.1021/acs.jmedchem.9b00004
Autor:
Yan A. Ivanenkov, Alex Zhavoronkov, Mark S. Veselov, Rim Shayakhmetov, Anastasiya V Aladinskaya, Daniil Polykovskiy, Victor A Terentiev, Vladimir A. Aladinskiy, Bogdan A Zagribelnyy, Tao Guo, Artem Zholus, Yury Volkov, Alexander Zhebrak, Lennart H Lee, Li Xing, Lidiya I Minaeva, Richard Soll, Alán Aspuru-Guzik, Alexander Aliper, David Madge, Maksim Kuznetsov, Arip Asadulaev
Publikováno v:
Nature Biotechnology. 37:1038-1040
We have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic feasibility, novelty, and biological activity. We used GENTRL to discover potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57935a11c69db73ee57db030f1e4ba3b
https://doi.org/10.1038/s41587-019-0224-x
https://doi.org/10.1038/s41587-019-0224-x
Publikováno v:
Journal of medicinal chemistry. 62(22)
The paradigm of "drug-like-ness" dramatically altered the behavior of the medicinal chemistry community for a long time. In recent years, scientists have empirically found a significant increase in key properties of drugs that have moved structures c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f6bcfe93cac37a667542448ee2dcc60
https://pubmed.ncbi.nlm.nih.gov/31188596
https://pubmed.ncbi.nlm.nih.gov/31188596
Autor:
Bogdan A. Zagribelnyy, Nikolai P. Savchuk, Yan A. Ivanenkov, Ruben N. Karapetian, Dmitry V. Kravchenko, Andrey Alexandrovich Ivashchenko, Angela G. Koryakova, Vladimir A. Aladinskiy, Alexey A Ryakhovskiy, Oleg D. Mitkin, Alexander Vasilievich Ivashchenko
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115716
A series of novel small-molecule pan-genotypic hepatitis C virus (HCV) NS5A inhibitors with picomolar activity containing 2-[(2S)-pyrrolidin-2-yl]-5-[4-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}buta-1,3-diyn-1-yl)phenyl]-1H-imidazole core was des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74edb34ccc38f734463a5dce567a6f7e
https://doi.org/10.1016/j.bmc.2020.115716
https://doi.org/10.1016/j.bmc.2020.115716