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Publikováno v:
British Journal of Clinical Pharmacology; 1990, Vol. 30 Issue 2, p292-296, 5p
Publikováno v:
British Journal of Pharmacology. 88:697-705
The beta-blocking effect of 4 beta-adrenoceptor antagonists with different pharmacokinetic properties was studied after intravenous and intraportal administration to control rats and to rats with experimental inflammation. In rats with inflammation t
Publikováno v:
Xenobiotica. 8:297-300
1. A gas chromatographic method is described for the quantitative determination of the metabolites of papaverine in urine. 2. The urinary excretion of papaverine metabolites was studied in man. About 50% of the metabolites of papaverine are excreted
Autor:
Frans M. Belpaire, Bogaert Mg
Publikováno v:
Xenobiotica. 5:431-438
1. The metabolism of papaverine was studied in vitro using the 9000 g fraction of rat liver. Apparent Km and Vmax values were 1.6 X 10-5 M and 34 nmol/g/min. Three monodemethylated metabolites were found by t.l.c. 2. Pre-treatment of rats with phenob
Publikováno v:
Xenobiotica. 5:413-420
1. After hydrolysis with glusulase of bile from rats treated with papaverine, four metabolites (A, B, C and D) were separated.2. The structures of A, B and C were established as the monodemethylated compounds, 4′-desmethyl-, 7-desmethyl-, and 6-des
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 7:123-126
Mise au point d'une methode rapide et sensible de dosage de la suramine dans le plasma de patients atteints du SIDA: utilisation de la chromatographie HPLC apres decontamination des echantillons a 56°C pendant 30 minutes
Autor:
Bogaert Mg, Frams M. Belpaire
Publikováno v:
Biochemical Pharmacology. 22:59-66
The excretion of 3 H-papaverine has been studied in the rat. After per oral as well as parenteral administration about 85 per cent of the administered radioactivity is excreted in faeces and urine in 4 days, and only negligible amounts of this radioa
Autor:
Belpaire Fm, Bogaert Mg
Publikováno v:
Acta clinica Belgica. 31(4)
Autor:
Bogaert Mg, Belpaire Fm
Publikováno v:
Acta clinica Belgica. 33(3)
Knowledge of the serum protein binding of drugs can be of clinical importance. After discussing the different methodological aspects of measuring protein binding, the effects of binding on differen...