Tissue-specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements.

Autor: Sinke L; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands., Beekman M; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands., Raz Y; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands., Gehrmann T; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.; Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Antwerp, Belgium., Moustakas I; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.; Sequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., Boulinguiez A; Myology Center for Research, U974, Sorbonne Université, INSERM, AIM, GH Pitié Salpêtrière Bat Babinski, Paris, France., Lakenberg N; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands., Suchiman E; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands., Bogaards FA; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.; Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands., Bizzarri D; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.; Delft Bioinformatics Lab, Pattern Recognition and Bioinformatics, Delft, The Netherlands., van den Akker EB; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.; Delft Bioinformatics Lab, Pattern Recognition and Bioinformatics, Delft, The Netherlands., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Munich, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Butler-Browne G; Myology Center for Research, U974, Sorbonne Université, INSERM, AIM, GH Pitié Salpêtrière Bat Babinski, Paris, France., Trollet C; Myology Center for Research, U974, Sorbonne Université, INSERM, AIM, GH Pitié Salpêtrière Bat Babinski, Paris, France., de Groot CPGM; Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands., Heijmans BT; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands., Slagboom PE; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.

Publikováno v: Aging cell [Aging Cell] 2024 Dec 01, pp. e14431. Date of Electronic Publication: 2024 Dec 01.

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults.

Autor: Bogaards FA; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Computational Biology Center, Leiden, The Netherlands.; Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands., Gehrmann T; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Computational Biology Center, Leiden, The Netherlands., Beekman M; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., van den Akker EB; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Computational Biology Center, Leiden, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands., van de Rest O; Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands., Hangelbroek RWJ; Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands., Noordam R; Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Mooijaart SP; Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., de Groot LCPGM; Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands., Reinders MJT; Leiden Computational Biology Center, Leiden, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands., Slagboom PE; Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2022 Nov; Vol. 36 (11), pp. e22578.