1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na V 1.7 inhibition.

Autor: Boezio AA; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States. Electronic address: aboezio@relaytx.com., Andrews K; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Boezio C; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Chu-Moyer M; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Copeland KW; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., DiMauro EF; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Foti RS; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Fremeau RT Jr; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Gao H; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Geuns-Meyer S; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Graceffa RF; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Gunaydin H; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Huang H; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., La DS; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Ligutti J; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States., Moyer BD; Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, United States., Peterson EA; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Yu V; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States., Weiss MM; Amgen, Inc., 360 Binney Street, Cambridge, MA 02142, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jun 15; Vol. 28 (11), pp. 2103-2108. Date of Electronic Publication: 2018 Apr 17.

Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.

Autor: Boezio AA; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Copeland KW; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Rex K; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States., K Albrecht B; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Bauer D; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Bellon SF; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Boezio C; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Broome MA; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Choquette D; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Coxon A; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Dussault I; Amgen Incorporated , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Hirai S; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Lewis R; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Lin MH; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Lohman J; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Liu J; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Peterson EA; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Potashman M; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Shimanovich R; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Teffera Y; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Whittington DA; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Vaida KR; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States., Harmange JC; Amgen Incorporated , 360 Binney Street, Cambridge, Massachusetts 02142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Mar 24; Vol. 59 (6), pp. 2328-42. Date of Electronic Publication: 2016 Feb 11.

Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.

Autor: Peterson EA, Teffera Y, Albrecht BK, Bauer D, Bellon SF, Boezio A, Boezio C, Broome MA, Choquette D, Copeland KW, Dussault I, Lewis R, Lin MH, Lohman J, Liu J, Potashman M, Rex K, Shimanovich R, Whittington DA, Vaida KR, Harmange JC

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 14; Vol. 58 (9), pp. 4087. Date of Electronic Publication: 2015 Apr 22.

La teologia nello spazio pubblico a prezzo di una de-teologizzazione? Teologico-politico, teologia "confessionale" e istanza apofatica.

Autor: HOLZER, Vincent

Publikováno v: Teologia. oct2023, Vol. 48 Issue 3, p457-501. 45p.

School-wide positive behavioural support in remote Australian schools: challenges in implementation.

Autor: Loucks, Laura, Beamish, Wendi, Hay, Stephen, Tyler, Mark

Publikováno v: Australian Educational Researcher (Springer Science & Business Media B.V.); Sep2024, Vol. 51 Issue 4, p1389-1404, 16p