Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.

Autor: Roden CA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Dai Y; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Giannetti CA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Seim I; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lee M; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA., Sealfon R; Flatiron Institute, Simons Foundation, New York, NY 10010, USA., McLaughlin GA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Boerneke MA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Iserman C; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wey SA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Ekena JL; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Troyanskaya OG; Flatiron Institute, Simons Foundation, New York, NY 10010, USA.; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA., Weeks KM; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., You L; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.; Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27708, USA., Chilkoti A; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA., Gladfelter AS; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Aug 12; Vol. 50 (14), pp. 8168-8192.

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.

Autor: Iserman C; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Roden CA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Boerneke MA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sealfon RSG; Center for Computational Biology, Flatiron Institute, New York, NY, USA., McLaughlin GA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Jungreis I; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fritch EJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ekena J; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Weidmann CA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Theesfeld CL; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Troyanskaya OG; Center for Computational Biology, Flatiron Institute, New York, NY, USA; Department of Computer Science, Princeton University, Princeton, NJ, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Weeks KM; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gladfelter AS; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: amyglad@unc.edu.

Publikováno v: Molecular cell [Mol Cell] 2020 Dec 17; Vol. 80 (6), pp. 1078-1091.e6. Date of Electronic Publication: 2020 Nov 27.

Pervasive tertiary structure in the dengue virus RNA genome.

Autor: Dethoff EA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599., Boerneke MA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599., Gokhale NS; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710., Muhire BM; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7000 Cape Town, South Africa., Martin DP; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 7000 Cape Town, South Africa., Sacco MT; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710., McFadden MJ; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710., Weinstein JB; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239., Messer WB; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239 weeks@unc.edu stacy.horner@duke.edu messer@ohsu.edu., Horner SM; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710; weeks@unc.edu stacy.horner@duke.edu messer@ohsu.edu., Weeks KM; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599; weeks@unc.edu stacy.horner@duke.edu messer@ohsu.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Nov 06; Vol. 115 (45), pp. 11513-11518. Date of Electronic Publication: 2018 Oct 19.

RNA three-dimensional structure drives the sequence organization of potato spindle tuber viroid quasispecies.

Autor: Wu, Jian^1,2,3 (AUTHOR) wujian@nbu.edu.cn, Zhang, Yuhong^1,2 (AUTHOR), Nie, Yuxin^1,2 (AUTHOR), Yan, Fei^1,2 (AUTHOR), Zirbel, Craig L.⁴ (AUTHOR), Bisaro, David M.³ (AUTHOR)

Publikováno v: PLoS Pathogens. 4/4/2024, Vol. 20 Issue 4, p1-24. 24p.

Design and Crystallography of Self-Assembling RNA Nanostructures.

Autor: Boerneke MA; Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Hermann T; Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. tch@ucsd.edu.; Center for Drug Discovery Innovation, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. tch@ucsd.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1632, pp. 135-149.