The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins

Autor: G. G. Edel, M. van Kempen, A. Boerema-de Munck, C. N. Huisman, C. A. P. Naalden, R. W. W. Brouwer, S. Koornneef, W. F. J. van IJcken, R. M. H. Wijnen, R. J. Rottier

Publikováno v: Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-17 (2024)

Abstract Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly associated with genomic alterations in the Forkhead box F1 (FOXF1) gene and its regulatory region. However, l

Externí odkaz: https://doaj.org/article/64a93163d0b443069e918dece0926290

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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Autor: Natalia Ortí-Casañ, Ate S. Boerema, Karina Köpke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. Kontermann, Ulrich L. M. Eisel

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the t

Externí odkaz: https://doaj.org/article/c98638b7b125423496722b05327a5864

What is the aetiology of dysnatraemia in COVID-19 and how is this related to outcomes in patients admitted during earlier and later COVID-19 waves? A multicentre, retrospective observational study in 11 Dutch hospitals

Autor: Babette Verkouteren, Dan Piña-Fuentes, Martijn Beudel, Thomas Ludden, Rik H G Olde Engberink, Tom Dormans, Martijn D de Kruif, Suat Simsek, Joop P van den Bergh, Hazra Moeniralam, Renee Douma, Kees Brinkman, Wouter Hinsenveld, Lucas Ramos, Anne Pirson, Deborah Hubers, Shi Hu, Rajat Thomas, Michiel Schinkel, Caroline E Wyers, Daisy Rusch, Lianne de Haan, Niels C Gritters van den Oever, Nienke Paternotte, Robert-Jan Goldhoorn, Brent Appelman, Esther Lems, Marije ten Wolde, Esther K Haspels-Hogervorst, Neyma Bokhizzou, Niels Gritters van den Oever, Joop van den Bergh, Martijn de Kruif, Helen Leavis, Derk Arts, Nick Nurmohamed, Rens Reeskamp, Willem Herter, Bas Vonk, Ricardo Lopes, Deborah Huberts, Marije Wolfers, Sander de Kuij, Sophie Noordzij, Sibbeliene van den Bosch, Benthe Verhoef, Michele Methorst, Shahan Darwesh, Tijn van Egmond, Gulsum Nasim, Hamza Ali, Lars de Boer, Myrthe Nagel, Maud Koenis, Agnetha Bijlsma, Britt Balvers, Isabella Ghauharali, Jelle de Jongh, Maira Emanuel, Nisrine Aynaou, Rosemarie de Ridder, Insaff Darraz, Oumaima Darraz, Alanar Cinar, Jesse Roosen, Larissa Heideman, Asabi Leliveld, Dana Ruijter, Neeltje Rosenberg, Djoeke Woutman, Tom Vermeulen, Sam de Joode, Willem Berger, Ozgu Varan, Soesja Pinto, Sientje Sluis, Bibi Kuiper, Tim van der Putten, Dominique Bosje, Mahunda Sinyangwe, Roos van Rhijn, Koen Kruif, Miriam den Heijer, Koen de Kruijf, Sam Hofhuis, Gwendolyn Telting, Susan van der Lei, Pien van Paassen, Emil ter Veer, Krijna Opschoor, Camille Breukhoven, Florine Jiwa, Peter de Gooyer, Jan Vrijdag, Stans van Gelder, Anne Pannekoek, Laura Dommershuijzen, Estelle Adang, Maud van Maren, Isabel Koop, Bart Sanders, Joukje Wanten, Dax Trommelen, Fleur Smeets, Kyra Heuvelings, Maud Cox, Milou Rademaekers, Vivian Hendrikx, Ilona van Rooij, Wendy Heuts, Laura Oudeman, Evelien Brans, Karin Slot, Kirsten Boerma-Argelo, Wilma Kok, Lieke Harmsen, Ingrid Boerema, Anne Raafs, Anne Smaal, Bibiane Pop, Carmen Waterink, Casper Vrij, Daphne van der Willik, Frederic Reitsma, Imogene Pieters, Jade Logger, Laura Sijben, Maikel Peeters, Mariël Teunissen, Marije Blok-Hoos, Marjolein Ketels, Michiel Henkens, Mireille Spanjers, Monique Jacob-Dols, Patrick de Hoogt, Rik Houben, Roos van Gorp, Josien Jansen

Publikováno v: BMJ Open, Vol 13, Iss 11 (2023)

Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk of intensive care unit (ICU) admission and all-cause mortality and to assess the underlying pathophysiological mechanism of hyponatrae

Externí odkaz: https://doaj.org/article/fad6410fff844b2180af17e45d668c56

A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures

Autor: Fernando Perez-Boerema, Mojtaba Barzegari, Liesbet Geris

Publikováno v: Virtual and Physical Prototyping, Vol 17, Iss 3, Pp 682-699 (2022)

Advances in additive manufacturing technologies are leading to an increased interest in the design of intricate 3D geometries for applications ranging from aerospace to biomedical engineering. In this paper, we present ASLI (A Simple Lattice Infiller

Externí odkaz: https://doaj.org/article/2d7018e50b1e4baebd93becb7ce5bcd9