Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation.

Autor: Cruz AR; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Boer MAD; Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands., Strasser J; Nano Structuring and Bio-Analytics Group, TIMed Center, University of Applied Sciences Upper Austria, 4020 Linz, Austria., Zwarthoff SA; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Beurskens FJ; Genmab, 3508 AD Utrecht, The Netherlands., de Haas CJC; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Aerts PC; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Wang G; Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands.; School of Chemistry and Materials Science, Nanjing Normal University, 210023 Nanjing, China., de Jong RN; Genmab, 3508 AD Utrecht, The Netherlands., Bagnoli F; GlaxoSmithKline (GSK) Siena, 53100 Siena, Italy., van Strijp JAG; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., van Kessel KPM; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Schuurman J; Genmab, 3508 AD Utrecht, The Netherlands., Preiner J; Nano Structuring and Bio-Analytics Group, TIMed Center, University of Applied Sciences Upper Austria, 4020 Linz, Austria., Heck AJR; Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands., Rooijakkers SHM; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands; S.H.M.Rooijakkers@umcutrecht.nl.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 16; Vol. 118 (7).