Výsledky vyhledávání - "Boer, R.J. de"

IL-2 regulates expansion of CD4+ T cell populations by affecting cell death: insight from modeling CFSE data

Autor: Ganusov, V.V., Milutinovic, D., Boer, R.J. de

Publikováno v: Journal of Immunology, 179, 950. American Association of Immunologists

It is generally accepted that IL-2 influences the dynamics of populations of T cells in vitro and in vivo. However, which parameters for cell division and/or death are affected by IL-2 is not well understood. To get better insights into the potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d54406e64b89bbda33dc52fdd3a6c344
https://dspace.library.uu.nl/handle/1874/22554

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The Effects of Age, Thymectomy, and HIV Infection on α and β TCR Excision Circles in Naive T Cells

Autor: Dool, C. van den, Boer, R.J. de

Publikováno v: Journal of Immunology, 177, 4391. American Association of Immunologists

Due to homeostasis total naive T cell numbers remain fairly constant over life despite a gradual involution of the thymus. The contribution of the thymus to maintaining naive T cell pools is typically measured with TCR excision circles (TRECs) that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::461f8d28b31c8979f85e71fa9e9e37e7
https://dspace.library.uu.nl/handle/1874/22576

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Establishment of the CD4+T cell pool in healthy and untreated HIV-1 infected children

Autor: Hazenberg, M.D., Otto, S.A., Rossum, A.M. van, Scherpbier, H.J., Groot, R. de, Kuijpers, T.W., Lange, J.M.A., Hamann, D., Boer, R.J. de, Borghans, J., Miedema, F.

Publikováno v: Blood, 1, 12, pp. 3513-9
Blood, 1, 3513-9

Contains fulltext : 58572.pdf (Publisher’s version ) (Closed access)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb93c362a94027d1ff979cecb2b0728f
https://hdl.handle.net/2066/58572

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Decline in excision circles is no evidence for homeostatic renewal of naive T cells

Autor: Dutilh, B., Boer, R.J. de

Publikováno v: Journal of theoretical biology, 224, 351. Elsevier

When the TCR is formed in the thymus, fragments of DNA are excised from the T cell progenitor chromosome. These TCR rearrangement excision circles (TRECs) are stable, are not replicated in cell division and are therefore most frequent in naive T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::07bd7083c9abf303430fb03a71ea211d
https://dspace.library.uu.nl/handle/1874/8555

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Estimating average cellular turnover from BrdU measurements

Autor: Boer, R.J. de, Mohri, H., Ho, D.D., Perelson, A.S.

Publikováno v: Proceedings. Biological sciences / The Royal Society, 270, 849. Royal Society of London

Cellular turnover rates in the immune system can be determined by labelling dividing cells with 5-bromo- 29-deoxyuridine (BrdU) or deuterated glucose ( ²H-glucose). To estimate the turnover rate from such measurements one has to fit a particular mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f663d6e5a96145ea4c02e0ffe2862398
https://dspace.library.uu.nl/handle/1874/8527

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Spatial model of affinity maturation in germinal centers

Autor: Kesmir, C., Boer, R.J. de

Publikováno v: Journal of Theoretical Biology, 222, 9. Elsevier

Affinity maturation of humoral responses to T-cell-dependent antigens occurs in germinal centers (GC). In GCs antigen-specific B cells undergo rounds of somatic mutations that alter their affinity. High-affinity mutants take over GCs very soon after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3f5a5537b0380ad7cb2ff37e260da82e
https://dspace.library.uu.nl/handle/1874/8553

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Different dynamics of CD4 and CD8 T cell responses during and after acute lymphocytic choriomeningitis virus infection

Autor: Boer, R.J. de, Homann, D., Perelson, A.S.

Publikováno v: Journal of immunology, 171(8), 3928. American Association of Immunologists

We fit a mathematical model to data characterizing the primary cellular immune response to lymphocytic choriomeningitis virus. The data enumerate the specific CD8(+) T cell response to six MHC class I-restricted epitopes and the specific CD4(+) T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f30440c3c2b7069638fc135e7bb0df4
https://dspace.library.uu.nl/handle/1874/8560

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Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation

Autor: Hazenberg, Mette D., Otto, S.A., Hamann, D., Roos, M.T., Schuitemaker, H., Boer, R.J. de, Miedema, F.

Publikováno v: AIDS, 17(10), 1419. Lippincott Williams & Wilkins

Using SCID-Hu mice models and in vitro culture systems, it has been shown that syncytium inducing/CXCR4 using (X4) HIV-1 variants affect thymic function through infection and killing of CXCR4 thymocytes. The effect of X4-emergence on naive, memory an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::efcea395467b48748046573b71273972
https://dspace.library.uu.nl/handle/1874/8551

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