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C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

Autor: Zwarthoff, Seline A., Widmer, Kevin, Kuipers, Annemarie, Strasser, Jürgen, Ruyken, Maartje, Aerts, Piet C., Haas, Carla J. C. de, Ugurlar, Deniz, Boer, Maurits A. den, Vidarsson, Gestur, Strijp, Jos A. G. van, Gros, Piet, Parren, Paul W. H. I., Kessel, Kok P. M. van, Preiner, Johannes, Beurskens, Frank J., Schuurman, Janine, Ricklin, Daniel, Rooijakkers, Suzan H. M., Structural Biochemistry, Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub Structural Biochemistry

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences, 118(26), 1. Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 118(26):e2102787118. National Academy of Sciences
Proceedings of the National Academy of Sciences, 118(26). NATL ACAD SCIENCES

Significance Antibody-dependent complement activation plays a major role in various pathophysiological processes in our body, including infection, inflammation, autoimmunity, and transplant rejection. In order to activate complement, antibodies shoul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e5d7e95385807acfa2f0813c9babf7
https://dspace.library.uu.nl/handle/1874/412418

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation.

Autor: Cruz AR; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Boer MAD; Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands., Strasser J; Nano Structuring and Bio-Analytics Group, TIMed Center, University of Applied Sciences Upper Austria, 4020 Linz, Austria., Zwarthoff SA; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Beurskens FJ; Genmab, 3508 AD Utrecht, The Netherlands., de Haas CJC; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Aerts PC; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Wang G; Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands.; School of Chemistry and Materials Science, Nanjing Normal University, 210023 Nanjing, China., de Jong RN; Genmab, 3508 AD Utrecht, The Netherlands., Bagnoli F; GlaxoSmithKline (GSK) Siena, 53100 Siena, Italy., van Strijp JAG; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., van Kessel KPM; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands., Schuurman J; Genmab, 3508 AD Utrecht, The Netherlands., Preiner J; Nano Structuring and Bio-Analytics Group, TIMed Center, University of Applied Sciences Upper Austria, 4020 Linz, Austria., Heck AJR; Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands., Rooijakkers SHM; Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands; S.H.M.Rooijakkers@umcutrecht.nl.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 16; Vol. 118 (7).