Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Boehm Terri L"'
Autor:
Jochem van Herpt, Don van Zwieten, Daniel P. Walker, Carroll Jeffery N, G. Davis Harris, Boehm Terri L, Kevin J. Koeller, Matthew D. McReynolds, Mangesh Bore, Justin R. Struble
Publikováno v:
Tetrahedron Letters. 60:1032-1036
Glyphosate [N-(phosphonomethyl)glycine] is a broad spectrum, post-emergent herbicide that is among the most widely used agrochemicals globally. Over the past 30 years, there has been a development of glyphosate-resistant weeds, which pose a significa
Autor:
Walker, Daniel P., Harris, G. Davis, Jr., Carroll, Jeffery N., Boehm, Terri L., McReynolds, Matthew D., Struble, Justin R., van Herpt, Jochem, van Zwieten, Don, Koeller, Kevin J., Bore, Mangesh
Publikováno v:
In Tetrahedron Letters 11 April 2019 60(15):1032-1036
Autor:
Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, Sheri L. Bonar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence
Autor:
Jeffery N. Carroll, Craig Swearingen, Decrescenzo Gary A, Rico Joseph G, Theresa R. Fletcher, Daniel P. Becker, Joseph J. McDonald, Susan L. Hockerman, Grace E. Munie, Stephen A. Kolodziej, Boehm Terri L, Debbie A. Mischke, Nathan W. Stehle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3557-3560
A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing
Publikováno v:
Synthetic Communications. 31:519-525
A route to the relatively rare pyrano[3,2-b]pyridin-4-one template (1) is described starting from 3-hydroxypyridine. This synthesis allows for varying the substituents at the 2- and 3-positions of the bicycle. A diisopropylsilyloxy moiety was employe
Autor:
Chris P. Carron, Madeleine H. Li, Daniel P. Becker, T. Sunyer, John N. Freskos, Louis J. Bedell, Boehm Terri L, Chris L. Funckes-Shippy, Decrescenzo Gary A, Clara I. Villamil, Joseph J. McDonald, Grace E. Munie, Jeffery N. Carroll, Pramod P. Mehta, Jun Yao, Brian R. Bond, Craig Swearingen, Jennifer M. Williams, Barta Thomas E, Marcia I. Heron, Dean Welsch, Karl J. Mathis, Carol Pearcy Howard, James R. Kiefer, Susan L. Hockerman, Alan M. Easton, Ying Yu
Publikováno v:
Journal of medicinal chemistry. 53(18)
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in th
Publikováno v:
ChemInform. 32
Autor:
Selness, Shaun R., Devraj, Rajesh V., Devadas, Balekudru, Walker, John K., Boehm, Terri L., Durley, Richard C., Shieh, Huey, Xing, Li, Rucker, Paul V., Jerome, Kevin D., Benson, Alan G., Marrufo, Laura D., Madsen, Heather M., Hitchcock, Jeff, Owen, Tom J., Christie, Lance, Promo, Michele A., Hickory, Brian S., Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika, Messing, Dean, Yang, Jerry, Mao, Michael K., Yalamanchili, Gopi, Vonder Embse, Richard, Hirsch, Jeffrey, Saabye, Matthew, Bonar, Sheri, Webb, Elizabeth, Anderson, Gary, Monahan, Joseph B.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 July 2011 21(13):4066-4071
Autor:
Selness, Shaun R., Boehm, Terri L., Walker, John K., Devadas, Balekudru, Durley, Richard C., Kurumbail, Ravi, Shieh, Huey, Xing, Li, Hepperle, Michael, Rucker, Paul V., Jerome, Kevin D., Benson, Alan G., Marrufo, Laura D., Madsen, Heather M., Hitchcock, Jeff, Owen, Tom J., Christie, Lance, Promo, Michele A., Hickory, Brian S., Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika, Devraj, Rajesh V., Messing, Dean, Schindler, John F., Hirsch, Jeffrey, Saabye, Matthew, Bonar, Sheri, Webb, Elizabeth, Anderson, Gary, Monahan, Joseph B.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 July 2011 21(13):4059-4065
Autor:
Chris P. Carron, Craig Swearingen, Louis J. Bedell, John N. Freskos, Getman Daniel P, Clara I. Villamil, Grace E. Munie, Pramod P. Mehta, Boehm Terri L, Barta Thomas E, Madeleine H. Li, Daniel P. Becker, Susan L. Hockerman, Susan C. Howard, Heintz Robert M, Joseph J. McDonald, Chris L. Funckes-Shippy, Decrescenzo Gary A
Publikováno v:
Journal of medicinal chemistry. 48(21)
alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unkn