Výsledky vyhledávání - "Body Composition/genetics"

Disentangling the genetics of lean mass

Autor: Tuomas O. Kilpeläinen, Jacqueline S. L. Kloth, Nam H. Cho, Peter Vollenweider, Georg Homuth, Unnur Thorsteinsdottir, Nicole C. Wright, Wen-Chi Chou, Yongmei Liu, Kari Stefansson, Kim M. Huffman, Ida Malkin, Andrew P. Morris, Robert Luben, Shad B. Smith, Lei Yu, Joel Eriksson, Aarno Palotie, Veikko Salomaa, Michael J. Econs, Liesbeth Vandenput, Elizabeth A. Streeten, Albert Hofman, Elisabeth Widen, Emmi Tikkanen, Braxton D. Mitchell, Natasja M. van Schoor, Caroline Hayward, Liisa Byberg, Joanne M. Jordan, Bruce M. Psaty, Elisabeth Steinhagen-Thiessen, Magnus Karlsson, Harry Campbell, John C. Chambers, Fernando Rivadeneira, Johan G. Eriksson, Jari Lahti, Reiner Biffar, James F. Wilson, Luda Diatchenko, Jerome I. Rotter, Eric S. Orwoll, Launer J. Lenore, Cornelia M. van Duijn, Frances M K Williams, Munro Peacock, David A. Bennett, Annette Peters, Ali A. Aghdassi, Gudny Eiriksdottir, Weihua Zhang, Östen Ljunggren, Daniel L. Koller, Nicole Soranzo, Patricia A. Thompson, Jane A. Cauley, John A Robbins, Mattias Lorentzon, Igor Rudan, Thomas Illig, Claes Ohlsson, Ilja Demuth, Zoltán Kutalik, Aron S. Buchman, Jian'an Luan, Erik Ingelsson, Natalia Campos-Obando, Karol Estrada, Chan Soo Shin, Lisette Stolk, Gudmar Thorleifsson, Douglas P. Kiel, Michael N. Weedon, Lars Bertram, Fiona E. McGuigan, Ben A. Oostra, Thomas Meitinger, Mary F. Feitosa, Christian Gieger, Jean Wactawski-Wende, Yanhua Zhou, Serkalem Demissie, Najaf Amin, Anke W. Enneman, Håkan Melhus, Stuart H. Ralston, Johanna Kuusisto, Markku Laakso, Mark Walker, Tim D. Spector, Karl Michaëlsson, John-Olov Jansson, Richard L. Prince, Leif Mosekilde, Sabine Schipf, Carolina Medina-Gomez, Antti Jula, Carrie M. Nielson, Bente L. Langdahl, André G. Uitterlinden, Kay-Tee Khaw, Ruth J. F. Loos, Kristina Åkesson, Albert V. Smith, Tamara B. Harris, Cynthia A. Thomson, Karin M. A. Swart, Unnur Styrkarsdottir, Yi-Hsiang Hsu, Anne B. Newman, Murielle Bochud, M. Carola Zillikens, Alena Stančáková, Markus M. Lerch, Maria Nethander, Gregory Livshits, Dawn Waterworth, Christina M. Lill, Henry Völzke, Steven R. Cummings, Lise B. Husted, Cecilia M. Lindgren, Jaspal S. Kooner, Joshua R. Lewis, Katri Räikkönen, Linda Broer, Inês Barroso, Teemu Kuulasmaa, Jeffery R. O'Connell, Harald Grallert, William E. Kraus, Nicholas J. Wareham, Lars Lind, David Karasik, H-Erich Wichmann, Gregory J. Tranah, Mao Fu, Toby Johnson, Samuli Ripatti, Dan Mellström, Suzanne Satterfield, Jing Hua Zhao, Hyung Jin Choi, Vilmundur Gudnason, Lisette C. P. G. M. de Groot, Stephen B. Kritchevsky, Zhao Chen, Norman Klopp, Till Ittermann, Daniel S. Evans, Phillip L. De Jager, Ingrid B. Borecki, Laura M. Yerges-Armstrong, Peggy M. Cawthon, Thomas Lang, Markus Perola

Publikováno v: The American Journal of Clinical Nutrition
American Journal of Clinical Nutrition 109 (2019) 2
American Journal of Clinical Nutrition, 109(2), 276-287. American Society for Nutrition
American Journal of Clinical Nutrition, 276-287. American Society for Nutrition
STARTPAGE=276;ENDPAGE=287;ISSN=0002-9165;TITLE=American Journal of Clinical Nutrition
The American journal of clinical nutrition
Karasik, D, Zillikens, M C, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chen, Z, Cho, N H, Choi, H J, Chou, W-C, Cummings, S R, de Groot, L C P G M, De Jager, P L, Demuth, I, Diatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Räikkönen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S B, Soranzo, N, Spector, T D, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Swart, K M A, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, N M, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H-E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', The American Journal of Clinical Nutrition, vol. 109, no. 2, pp. 276-287 . https://doi.org/10.1093/ajcn/nqy272
Karasik, D, Zillikens, M C, Hsu, Y H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Swart, KMA, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chou, W C, Demuth, I, DIatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Chen, Z, Cho, N H, Choi, H J, Cummings, S R, de Groot, L C P G M, de Jager, P L, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C M, Lind, L, Lindgren, C M, Liu, Y, Livshits, G, Ljunggren, O, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gómez, C, Meitinger, T, Melhus, H, Mellstrom, D, Michaelsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Raikkonen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S, Soranzo, N, Spector, T D, Stancakova, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, NM, Vandenput, L, Vollenweider, P, Volzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', American Journal of Clinical Nutrition, pp. 276-287 .
Karasik, D, Zillikens, M C, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chen, Z, Cho, N H, Choi, H J, Chou, W-C, Cummings, S R, de Groot, L C P G M, De Jager, P L, Demuth, I, Diatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Räikkönen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S B, Soranzo, N, Spector, T D, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Swart, K M A, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, N M, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H-E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', The American Journal of Clinical Nutrition (AJCN) . https://doi.org/10.1093/ajcn/nqy272
Karasik, D, Zillikens, M C, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chen, Z, Cho, N H, Choi, H J, Chou, W-C, Cummings, S R, de Groot, L C P G M, De Jager, P L, Demuth, I, Diatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Räikkönen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S B, Soranzo, N, Spector, T D, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Swart, K M A, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, N M, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H-E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', The American journal of clinical nutrition, vol. 109, no. 2, pp. 276-287 . https://doi.org/10.1093/ajcn/nqy272
American Journal of Clinical Nutrition, 109(2), 276-278

Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b768501bad6cfbb2327b96cc06a631
https://doi.org/10.1093/ajcn/nqy272

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Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

Publikováno v: Small, K S, Marijana, M, Civelek, M, El-Sayed Moustafa, J S, Wang, X, Simon, M M, Tajes, J F, Mahajan, A, Horikoshi, M, Hugill, A, Glastonbury, C A, Quaye, L, Neville, M J, Sethi, S, Yon, M, Pan, C, Che, N, Vinuela, A, Tsai, P-C, Nag, A, Buil, A, Thorleifsson, G, Raghavan, A, Ding, Q, Morris, A P, Bell, J T, Thorsteinsdottir, U, Stefansson, K, Laakso, M, Dahlman, I, Arner, P, Gloyn, A L, Musunuru, K, Lusis, A J, Cox, R D, Karpe, F & McCarthy, M I 2018, ' Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition ', Nature Genetics, vol. 50, pp. 572–580 . https://doi.org/10.1038/s41588-018-0088-x
Nature Genetics
Small, K S, Todorčević, M, Civelek, M, El-Sayed Moustafa, J S, Wang, X, Simon, M M, Fernandez-Tajes, J, Mahajan, A, Horikoshi, M, Hugill, A, Glastonbury, C A, Quaye, L, Neville, M J, Sethi, S, Yon, M, Pan, C, Che, N, Viñuela, A, Tsai, P-C, Nag, A, Buil, A, Thorleifsson, G, Raghavan, A, Ding, Q, Morris, A P, Bell, J T, Thorsteinsdottir, U, Stefansson, K, Laakso, M, Dahlman, I, Arner, P, Gloyn, A L, Musunuru, K, Lusis, A J, Cox, R D, Karpe, F & McCarthy, M I 2018, ' Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition ', Nature Genetics, vol. 50, no. 4, pp. 572-580 . https://doi.org/10.1038/s41588-018-0088-x

Individual risk of type 2 diabetes (T2D) is modified by perturbations of adipose mass, distribution and function. To investigate mechanisms responsible, we explored the molecular, cellular, and whole-body effects of T2D-associated alleles near KLF14.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2a48142a73254b78b7f405200b5b31
https://doi.org/10.1038/s41588-018-0088-x

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Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study

Autor: Zuzana Lohse, Birgitte Bytoft, Kurt Højlund, Henning Beck-Nielsen, Rikke Beck Jensen, Sine Knorr, Claus Højbjerg Gravholt, Peter Oturai, Dorte Møller Jensen, Peter Damm, Tine D. Clausen

Publikováno v: Lohse, Z, Knorr, S, Bytoft, B, Clausen, T D, Jensen, R B, Oturai, P, Beck-Nielsen, H, Gravholt, C H, Damm, P, Højlund, K & Jensen, D M 2018, ' Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study ', Diabetologia, vol. 61, no. 1, pp. 210-219 . https://doi.org/10.1007/s00125-017-4458-1
Lohse, Z, Knorr, S, Bytoft, B, Clausen, T D, Jensen, R B, Oturai, P, Beck-Nielsen, H, Gravholt, C H, Damm, P, Højlund, K & Jensen, D M 2018, ' Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes : results from the EPICOM study ', Diabetologia, vol. 61, no. 1, pp. 210–219 . https://doi.org/10.1007/s00125-017-4458-1

AIMS/HYPOTHESIS: The aim of this study was to investigate the influence of age and sex on insulin sensitivity and insulin secretion in the adolescent offspring of women with type 1 diabetes, compared with the background population.METHODS: This was a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27fc7ac40d2c343619ea7bb4af1465b
https://doi.org/10.1007/s00125-017-4458-1

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Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood: a family-based study

Autor: Torben Hansen, Anette P. Gjesing, Mette Hollensted, Hans Eiberg, Claus Thorn Ekstrøm, Oluf Pedersen

Publikováno v: BMC Medical Genetics
Hollensted, M, Ekstrøm, C T, Pedersen, O, Eiberg, H, Hansen, T & Gjesing, A P 2018, ' Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood : a family-based study ', BMC Medical Genetics, vol. 19, 207, pp. 1-9 . https://doi.org/10.1186/s12881-018-0718-2
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-9 (2018)
Hollensted, M, Ekstrøm, C T, Pedersen, O, Eiberg, H, Hansen, T & Gjesing, A P 2018, ' Genetic insights into fetal growth and measures of glycaemic regulation and adiposity in adulthood : A family-based study ', BMC Medical Genetics, vol. 19, 207 . https://doi.org/10.1186/s12881-018-0718-2

Background The genetics of fetal insulin release and/or action have been suggested to affect fetal growth, adult insulin resistance and adult body composition. The genetic correlation between body composition at birth versus glycaemic regulation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dea10530c89f25d3e2c31d69ee2b28
http://europepmc.org/articles/PMC6278142

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Seven Novel Deleterious LEPR Mutations Found in Early-Onset Obesity: a ΔExon6–8 Shared by Subjects From Reunion Island, France, Suggests a Founder Effect

Autor: Martine Laville, Marc Nicolino, Hélène Huvenne, Erwan Jeannic, Amélie Viard, Béatrice Dubern, Séverine Ledoux, Patrick Tounian, Johanne Le Beyec, Jean-Marc Lacorte, Marie-Laure Frelut, Christine Poitou, Rohia Alili, Karine Clément, Patricia Pigeon Kherchiche, Dominique Pepin

Publikováno v: Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2015, 100 (5), pp.E757-66. ⟨10.1210/jc.2015-1036⟩

International audience; CONTEXT: Infrequent mutations have been reported in the leptin receptor (LEPR) gene in humans with morbid obesity and endocrine disorders. However LEPR mutations are rarely examined in large populations from different ethnicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be71c9e7f800a554ed5db244609606a
https://doi.org/10.1210/jc.2015-1036

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The impact of genetic variants on BMI increase during childhood versus adulthood

Autor: Paolo Piaggi, Maximilian G. Hohenadel, Yunhua L. Muller, Jonathan Krakoff, Robert L. Hanson, Leslie J. Baier, Marie S. Thearle

Publikováno v: Int J Obes (Lond)

BACKGROUND: Genetic variants that predispose individuals to obesity may have differing influences during childhood versus adulthood, and additive effects of such variants are likely to occur. Our ongoing studies to identify genetic determinants of ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82bf06119def218c71d70c9fa19e97c
https://pubmed.ncbi.nlm.nih.gov/27076275

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Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Autor: Teumer, Alexander, Qi, Qibin, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja, Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen, Chen, Ming-Huei, Chen, Tai, Chen, Yii-Der Ida, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, Friedrich, Nele, Gnewuch, Carsten, Goodarzi, Mark, Grarup, Niels, Guo, Tingwei, Hammer, Elke, Hayes, Richard, Hicks, Andrew, Hofman, Albert, Houwing-Duistermaat, Jeanine, Hu, Frank, Hunter, David, Husemoen, Lise, Isaacs, Aaron, Jacobs, Kevin, Janssen, Joop, Jansson, John-Olov, Jehmlich, Nico, Johnson, Simon, Juul, Anders, Karlsson, Magnus, Kilpelainen, Tuomas, Kovacs, Peter, Kraft, Peter, Li, Chao, Linneberg, Allan, Liu, Yongmei, Loos, Ruth, Lorentzon, Mattias, Lu, Yingchang, Maggio, Marcello, Magi, Reedik, Meigs, James, Mellström, Dan, Nauck, Matthias, Newman, Anne, Pollak, Michael, Pramstaller, Peter, Prokopenko, Inga, Psaty, Bruce, Reincke, Martin, Rimm, Eric, Rotter, Jerome, Saint Pierre, Aude, Schurmann, Claudia, Seshadri, Sudha, Sjögren, Klara, Slagboom, P Eline, Strickler, Howard, Stumvoll, Michael, Suh, Yousin, Sun, Qi, Zhang, Cuilin, Svensson, Johan, Tanaka, Toshiko, Tare, Archana, Tönjes, Anke, Uh, Hae-Won, Van Duijn, Cornelia, van Heemst, Diana, Vandenput, Liesbeth, Vasan, Ramachandran, Völker, Uwe, Willems, Sara, Ohlsson, Claes, Wallaschofski, Henri, Kaplan, Robert, Chen, Ming‐Huei, Chen, Yii‐Der Ida, Houwing‐Duistermaat, Jeanine, Jansson, John‐Olov, Slagboom, P. Eline, Uh, Hae‐Won, Heemst, Diana

Publikováno v: Aging Cell
Aging Cell, 15(5), 811-824
Aging cell, vol 15, iss 5
Aging Cell, Wiley Open Access, 2016, 15 (5), pp.811-824. ⟨10.1111/acel.12490⟩
Aging Cell, 15(5), 811-824. Wiley-Blackwell
Aging Cell, 15(5), 811-824. Wiley-Blackwell Publishing Ltd

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c71dde8374929bb179f43c80584539

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Munc18/Syntaxin Interaction Kinetics Control Secretory Vesicle Dynamics*

Autor: Colin Rickman, Rory R. Duncan

Publikováno v: The Journal of Biological Chemistry
Rickman, C & Duncan, R R 2010, ' Munc18/Syntaxin Interaction Kinetics Control Secretory Vesicle Dynamics ', Journal of Biological Chemistry, vol. 285, no. 6, pp. 3965-3972 . https://doi.org/10.1074/jbc.M109.040402

In neuronal and hormonal release, regulated exocytosis requires an essential set of proteins: the soluble N-ethylmaleimide sensitive-factor attachment receptor proteins (SNAREs) syntaxin 1, SNAP-25, VAMP, and their regulator, Munc18. Recently, it was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069dbbee2f1066308cdfc08cdee8295c
http://europepmc.org/articles/PMC2823538

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Anthropometry in Klinefelter syndrome - multifactorial influences due to CAG length, testosterone treatment and possibly intrauterine hypogonadism

Autor: John R. Østergaard, Arieh Cohen, Anders Degn Pedersen, Simon Chang, David M. Hougaard, Jens Michael Hertz, Christian Trolle, Mikkel Wallentin, Claus Højbjerg Gravholt, Anders Bojesen, Anne Skakkebæk

Publikováno v: Chang, S, Skakkebæk, A, Trolle, C, Bojesen, A, Hertz, J M, Cohen, A, Hougaard, D M, Wallentin, M, Pedersen, A D, Østergaard, J R & Gravholt, C H 2015, ' Anthropometry in Klinefelter syndrome-multifactorial influences due to CAG length, testosterone treatment and possibly intrauterine hypogonadism ', Journal of Clinical Endocrinology and Metabolism, bind 100, nr. 3, jc20142834, s. E508-E517 . https://doi.org/10.1210/jc.2014-2834
Chang, S, Skakkebæk, A, Trolle, C, Bojesen, A, Hertz, J M, Cohen, A, Hougaard, D M, Wallentin, M, Pedersen, A D, Ostergaard, J R & Gravholt, C H J 2015, ' Anthropometry in Klinefelter syndrome-multifactorial influences due to CAG length, testosterone treatment and possibly intrauterine hypogonadism ', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 3, pp. E508-E517 . https://doi.org/10.1210/jc.2014-2834

Context: Klinefelter syndrome, 47, XXY (KS), is underdiagnosed partly due to few clinical signs complicating identification of affected individuals. Certain phenotypic traits are common in KS. However, not all aspects of the KS phenotype are well des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b4153d55c2397858a5383cccc9326
https://pure.au.dk/portal/da/publications/anthropometry-in-klinefelter-syndrome--multifactorial-influences-due-to-cag-length-testosterone-treatment-and-possibly-intrauterine-hypogonadism(3f0a9c17-b7ce-43d5-998d-c88671fb5c99).html

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Meta-analysis of the effect of the halothane gene on 6 variables of pig meat quality and on carcass leanness

Autor: BOUKHARI SALMI, Btissam, Trefan, L., Bloom-Hansen, J., Bidanel, Jean Pierre, Doeschl-Wilson, A.B., Larzul, Catherine

Publikováno v: Journal of Animal Science
Journal of Animal Science, American Society of Animal Science, 2010, 88 (9), pp.2841-2855. ⟨10.2527/jas.2009-2508⟩
Salmi, B, Trefan, L, Bloom-Hansen, J, Bidanel, J P, Doeschl-Wilson, A B & Larzul, C 2010, ' Meta-analysis of the effect of the halothane gene on 6 variables of pig meat quality and on carcass leanness ', Italian Journal of Animal Science, vol. 88, no. 9, pp. 2841-2855 . https://doi.org/10.2527/jas.2009-2508

Technological meat quality is a significant economic factor in pork production, and numerous publications have shown that it is strongly influenced both by genetic status and by rearing and slaughter conditions. The quality of meat is often described

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::41bf1ff7070d10ca686bf020bf45d53f
https://hal.archives-ouvertes.fr/hal-01193357

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