Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bodvael Pennarun"'
Autor:
Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong
Publikováno v:
Analytical Cellular Pathology, Vol 33, Iss 5-6, Pp 229-244 (2010)
Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) initiates apoptosis in tumor cells upon binding to its cognate agonistic receptors, death receptors 4 and 5 (DR4 and DR5). The activity of the insulin-like growth factor 1 (I
Externí odkaz:
https://doaj.org/article/4c4172c9127e433aad30315e20b40f58
Autor:
Octavian Bucur, Andreea Lucia Stancu, Ioana Goganau, Stefana Maria Petrescu, Bodvael Pennarun, Thierry Bertomeu, Rajan Dewar, Roya Khosravi-Far
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77390 (2013)
Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new therapeutic strategies. We and others have previously established bortezomib, a selective prote
Externí odkaz:
https://doaj.org/article/9b01a2611d5a4c6c886b3dc6d9130a42
Autor:
Bodvael Pennarun, Anja Schempf, Bo Yang, Parisa Mousavi Shafaei, Da Yang, Dipak Datta, Barbara L. Hopkins, Steffi Oesterreich, Octavian Bucur, Thierry Bertomeu, John J. Skoko, Andrea Pelosi, Kenneth Ndebele, Carola A. Neumann, Kevin M. Levine, Monica J. S. Nadler, Maria Giulia Rizzo, Roya Khosravi-Far
Publikováno v:
Antioxidants & Redox Signaling
Precision in redox signaling is attained through posttranslational protein modifications such as oxidation of protein thiols. The peroxidase peroxiredoxin 1 (PRDX1) regulates signal transduction through changes in thiol oxidation of its cysteines. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80e85936d2ed72d4b56a8d948e468c6
https://pubmed.ncbi.nlm.nih.gov/28398822
https://pubmed.ncbi.nlm.nih.gov/28398822
Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP
Autor:
Maria Sinziana Muraru, Thierry Bertomeu, Octavian Bucur, Andreea Lucia Stancu, Monica J. S. Nadler, Bodvael Pennarun, Roya Khosravi-Far
Publikováno v:
Apoptosis. 18:1154-1162
Successful translation of findings derived from preclinical studies into effective therapies is critical in biomedical research. Lack of robustness and reproducibility of the preclinical data, due to insufficient number of repeats, inadequate cell-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0b4a950ed45cd05648fa584937ce37
https://doi.org/10.1007/s10495-013-0880-0
https://doi.org/10.1007/s10495-013-0880-0
Autor:
Elisabeth G.E. de Vries, Harry Hollema, Bodvael Pennarun, Frank A.E. Kruyt, Steven de Jong, Wytske Boersma-van Ek, Jan H. Kleibeuker
Publikováno v:
The Journal of Pathology. 229:410-421
The multikinase inhibitor sorafenib is highly effective against certain types of cancer in the clinic and prevents colon cancer cell proliferation in vitro. Non-steroidal anti-inflammatory drugs, such as acetylsalicylic acid (aspirin), have shown act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee8db7dea2cf9bc9e5696f85100e555
https://doi.org/10.1002/path.4138
https://doi.org/10.1002/path.4138
Autor:
Elisabeth G.E. de Vries, Bodvael Pennarun, Diana C.J. Spierings, Steven de Jong, Wytske Boerma-Van Ek, Phuong T. K. Le, Caroline M. M. van Geelen
Publikováno v:
International journal of oncology, 37(4), 1031-1041. SPANDIDOS PUBL LTD
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers the apoptotic cascade in various colon cancer cell lines after binding to the membrane receptors DR4 and DR5. However, not all cancer cell lines are sensitive to the therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8001a4f623d2b056b5825fe399e5d03b
https://hdl.handle.net/11370/d51a2bcc-2c0c-49b3-983a-2871950f90f1
https://hdl.handle.net/11370/d51a2bcc-2c0c-49b3-983a-2871950f90f1
Autor:
Alexandra E. Panaitiu, Dale F. Mierke, Bodvael Pennarun, Stefan Andrei, Maria Pellegrini, Chamila N. Rupasinghe, Roya Khosravi-Far, Bingqian Guo, Jérémie Roux, Octavian Bucur, Gabriel Gaidos, Achani K. Yatawara
Publikováno v:
Scientific Reports
Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR5) are currently being created for clinical cancer therapy, due to their selective killing of cancer cells and high safety characteristics. However, resistance to T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4751bebfdf00d764cff6889c4ad7b8
https://doi.org/10.1038/srep09893
https://doi.org/10.1038/srep09893
Autor:
Thierry Bertomeu, Bodvael Pennarun, Rajan Dewar, Octavian Bucur, Ioana Goganau, Andreea Lucia Stancu, Stefana M. Petrescu, Roya Khosravi-Far
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77390 (2013)
PLoS ONE
PLoS ONE
Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new therapeutic strategies. We and others have previously established bortezomib, a selective prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e96151ba67cb375d499881f72e577a0
http://europepmc.org/articles/PMC3796452?pdf=render
http://europepmc.org/articles/PMC3796452?pdf=render
Autor:
Bodvael Pennarun, Elisabeth G.E. de Vries, Steven de Jong, Frank A.E. Kruyt, Jan H. Kleibeuker, Annemieke Meijer
Publikováno v:
Biochimica et biophysica acta. 1805(2)
Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e1784e67a71f497a5e22778272044a
https://pubmed.ncbi.nlm.nih.gov/19961901
https://pubmed.ncbi.nlm.nih.gov/19961901
Autor:
Chamila N. Rupasinghe, Rajan Dewar, Roya Khosravi-Far, Bodvael Pennarun, Keli Song, Octavian Bucur, Antonella Tinari, Tai-Guang Jin, Dale F. Mierke, Gabriel Gaidos, Maria Tanya Santos, Walter Malorni
Publikováno v:
Cell Death & Disease
One of the objectives in the development of effective cancer therapy is induction of tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cells via a TAT cell-delivery system, shows a remarkably p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c72ebd6a8bbfb82a2edf7188af980d
https://doi.org/10.1038/cddis.2013.401
https://doi.org/10.1038/cddis.2013.401