Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

Autor: M. Bellani, Marvin L. Meistrich, J. Schimenti, Toru Nakano, Maria Jasin, Marco Barchi, T de Lange, G. Petukhova, Rafael Daniel Camerini‐Otero, Herbert Braselmann, Scott Keeney, Harry Scherthan, Tej K. Pandita, W. M. Baarends, Bodo Liebe, Albert J. Fornace

Publikováno v: Experimental Cell Research, 312(19), 3768-3781. Elsevier Inc.

Meiosis pairs and segregates homologous chromosomes and thereby forms haploid germ cells to compensate the genome doubling at fertilization. Homologue pairing in many eukaryotic species depends on formation of DNA double strand breaks (DSBs) during e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1d42cebb1040d90d81816f066011e7
https://hdl.handle.net/1765/65827

Disruption of spermatogenesis in mice lacking A-type lamins

Autor: Bodo Liebe, Manfred Alsheimer, Ricardo Benavente, Colin L. Stewart, Lori Sewell, Harry Scherthan

Publikováno v: Journal of Cell Science. 117:1173-1178

Nuclear lamins are structural protein components of the nuclear envelope. Mutations in LMNA, the gene coding for A-type lamins, result in several human hereditary diseases, the laminopathies, which include Emery-Dreifuss muscular dystrophy, dilated c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13ef0e453d1cc55494b7a486b013def
https://doi.org/10.1242/jcs.00975

Telomere-independent homologue pairing and checkpoint escape of accessory ring chromosomes in male mouse meiosis

Autor: Bodo Liebe, Charlotte Labaere, Thierry Voet, Harry Scherthan, Peter Marynen

Publikováno v: The Journal of Cell Biology

We analyzed transmission of a ring minichromosome (MC) through mouse spermatogenesis as a monosome and in the presence of a homologue. Mice, either monosomic or disomic for the MC, produced MC+ offspring. In the monosomic condition, most univalents u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a5b86dbb32577c57d36f68f635d9ec
http://europepmc.org/articles/PMC2172825

Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis

Autor: Manuel Mark, Alexandra Chicheportiche, Paolo Sassone-Corsi, Lucia Monaco, Delphine Quénet, Harry Scherthan, Aline Huber, Françoise Dantzer, Bodo Liebe, Gilbert de Murcia, Josiane Ménissier-de Murcia

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2006, 103 (40), pp.14854-9. ⟨10.1073/pnas.0604252103⟩

Besides the established central role of poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 in the maintenance of genomic integrity, accumulating evidence indicates that poly(ADP-ribosyl)ation may modulate epigenetic modifications under physiological c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70250c5f560d840a15b862503084605
https://hal.archives-ouvertes.fr/hal-00179859

Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination

Autor: Patricia A. Hunt, Maureen Eijpe, Ekaterina Revenkova, Rolf Jessberger, Christa Heyting, Harry Scherthan, Bodo Liebe, Craig A. Hodges

Publikováno v: Nature Cell Biology 6 (2004) 6
Nature Cell Biology, 6(6), 555-562

Sister chromatid cohesion ensures the faithful segregation of chromosomes in mitosis and in both meiotic divisions. Meiosis-specific components of the cohesin complex, including the recently described SMC1 isoform SMC1 beta, were suggested to be requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba50e4f86fee10d490831f1b7ec464
https://research.wur.nl/en/publications/cohesin-smc1-beta-is-required-for-meiotic-chromosome-dynamics-sis