Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bodo Lachmann"'
Autor:
Bodo Lachmann, Simon Eppacher, Christian Miculka, Christian R. Noe, Peter Richter, Jerome Freissmuth
Publikováno v:
Life, Vol 3, Iss 3, Pp 486-501 (2013)
Experiments will be presented and reviewed to support the hypothesis that the intrinsic reactivity of formaldehyde may lead to the formation of a rather comprehensive set of defined biomolecules, including D-glucose, thus fostering concepts of evolut
Externí odkaz:
https://doaj.org/article/7ac96c50d1f54c04bbb36885837e2664
Autor:
Iveta Novakova, Eva-Anne Subileau, Stefan Toegel, Daniela Gruber, Bodo Lachmann, Ernst Urban, Christophe Chesne, Christian R Noe, Winfried Neuhaus
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86806 (2014)
The aim of this work was to conduct a comprehensive study about the transport properties of NSAIDs across the blood-brain barrier (BBB) in vitro. Transport studies with celecoxib, diclofenac, ibuprofen, meloxicam, piroxicam and tenoxicam were accompl
Externí odkaz:
https://doaj.org/article/1c4402f3dcbb4e7d97088844741a5b20
Publikováno v:
Future Medicinal Chemistry. 7:1657-1673
Background: Despite recent advances, major hurdles still need to be cleared for widespread application of therapeutic antisense technologies. In particular, pharmacokinetic properties and efficient cellular uptake need to be improved through chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe63eafc0a68446266efe7293194d69
https://doi.org/10.4155/fmc.15.109
https://doi.org/10.4155/fmc.15.109
Publikováno v:
International Journal of Molecular Sciences; Volume 15; Issue 4; Pages: 6399-6411
International Journal of Molecular Sciences, Vol 15, Iss 4, Pp 6399-6411 (2014)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 15, Iss 4, Pp 6399-6411 (2014)
International Journal of Molecular Sciences
Recombinant monoclonal antibodies (rmAbs) are medicinal products obtained by rDNA technology. Consequently, like other biopharmaceuticals, they require the extensive and rigorous characterization of the quality attributes, such as identity, structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baf4124fff4b33847bd7f4e2d438f60
https://doi.org/10.3390/ijms15046399
https://doi.org/10.3390/ijms15046399
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 37:1321-1333
A simple, rapid, selective, accurate, and stability-indicating HPLC method for the simultaneous determination of naphazoline and methyl parahydroxybenzoate in pharmaceutical preparations was developed and validated. The method employs a BDS Hypersil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a050dffc25dba3c5a0d104ff4a8122e
https://doi.org/10.1080/10826076.2013.789802
https://doi.org/10.1080/10826076.2013.789802
Publikováno v:
Scientia Pharmaceutica
Volume 80
Issue 2
Pages 311-316
Volume 80
Issue 2
Pages 311-316
Capillary electrophoresis is competitive to HPLC and other chromatographic methods, predominantly when charged analytes have to be separated. The time of analysis can be reduced by the use of very short capillaries applying a high voltage. In most in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e531661b1febe5c2224855446927a377
https://doi.org/10.3797/scipharm.1201-02
https://doi.org/10.3797/scipharm.1201-02
Autor:
Hermann Wätzig, Hendrik Schmidt, Dashnor Nebija, Simone Schröder, Sabine Redweik, Bodo Lachmann, Xi Deng, Thomas Hahne, Ottmar Janssen
Publikováno v:
ELECTROPHORESIS. 33:263-269
Single proteins separated by 2-DE often show multiple spots spreading along the first dimension. In many cases, such charge trains are explained by isoform differences or by putative post-translational modifications including phosphorylation, glycosy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f13e42017845a7b2857aad556ec0e4b
https://doi.org/10.1002/elps.201100321
https://doi.org/10.1002/elps.201100321
Publikováno v:
European Journal of Organic Chemistry. 2011:3126-3130
The N-2,4-dinitrophenylsulfonyl group (dinosyl, DNs) was found to be an excellent choice for the N-activation of aziridines towards ring cleavage with primary, secondary, andsterically demanding tertiary alcohols. Alcoholysis does not need any additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8417450f602c8faa38073e8e34855c9
https://doi.org/10.1002/ejoc.201100358
https://doi.org/10.1002/ejoc.201100358
Autor:
Dashnor Nebija, Takeshi Furuhashi, Miloslav Smrz, Christian R. Noe, Bettina Germann, Ivan Mikšík, Bodo Lachmann
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 155:195-200
Acidic macromolecules, as a nucleation factor for mollusc shell formation, are a major focus of research. It remains unclear, however, whether acidic macromolecules are present only in calcified shell organic matrices, and which acidic macromolecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b999d0bc12c259ba48180fa1df2a95e0
https://doi.org/10.1016/j.cbpb.2009.11.007
https://doi.org/10.1016/j.cbpb.2009.11.007
Autor:
Michael Wirth, Franz Gabor, Bettina Germann, V.E. Plattner, Winfried Neuhaus, Christian R. Noe, Bodo Lachmann
Publikováno v:
Journal of Pharmaceutical Sciences. 97:5158-5175
In the course of the validation of blood-brain barrier in vitro models the aim of this work was to characterize two promising continuous cell lines with regard to their tightness properties. PBMEC/C1-2 and ECV304 cells were cultured in several media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9873b60fe3bafc048a0538712f31180
https://doi.org/10.1002/jps.21371
https://doi.org/10.1002/jps.21371