Výsledky vyhledávání - "Bodo, Brunner"

Akademický článek

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Autor: Suryaprakash Raichur, Bodo Brunner, Maximilian Bielohuby, Gitte Hansen, Anja Pfenninger, Bing Wang, Jens C. Bruning, Philip Just Larsen, Norbert Tennagels

Publikováno v: Molecular Metabolism, Vol 21, Iss , Pp 36-50 (2019)

Objective: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the devel

Externí odkaz: https://doaj.org/article/ed86172c67e2412399a12318a5414e66

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Akademický článek

Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice

Autor: Nicole Ziegler, Suryaprakash Raichur, Bodo Brunner, Ulrike Hemmann, Manuela Stolte, Uwe Schwahn, Hans-Peter Prochnow, Christiane Metz-Weidmann, Norbert Tennagels, Daniel Margerie, Paulus Wohlfart, Maximilian Bielohuby

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

Histone deacetylases (HDACs) are important regulators of epigenetic gene modification that are involved in the transcriptional control of metabolism. In particular class IIa HDACs have been shown to affect hepatic gluconeogenesis and previous approac

Externí odkaz: https://doaj.org/article/74f32a6ec3d54b29892a56ffad88cff3

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Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down

Autor: Armin Hofmeister, Kerstin Jahn-Hofmann, Bodo Brunner, Mike Helms, Christiane Metz-Weidmann, Arne Krack, Michael Kurz, Christoph Heubel, Sabine Scheidler

Publikováno v: Journal of Medicinal Chemistry. 65:13736-13752

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d15651602661ac7766e15b8619f3464
https://doi.org/10.1021/acs.jmedchem.2c00873

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Supplementary Data from Utility of the RIG-I Agonist Triphosphate RNA for Melanoma Therapy

Autor: Lars M. König, Bodo Brunner, Simon Rothenfußer, Sabine Scheidler, Dmitri Wiederschain, Stefan Endres, Max M. Schnurr, Timothy R. Wagenaar, Hui Cao, Joachim Theilhaber, Kaj Grandien, Petra Scherer, Gabriele Dietert, Monika Braun, Christiane Metz-Weidmann, Felix Gnerlich, Kerstin Jahn-Hofmann, Mike W. Helms

Supplementary Figure S1 shows that RIG-I, MDA and IRF7 mRNA expression are correlated to the Type I IFN signature in melanoma, while MAVS, TBK1 and IRF3 are not. Supplementary Figure S2 shows a list of gene products correlated with RIG-I expression b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a4da953aaf859e66a4a0df15ab8f8b
https://doi.org/10.1158/1535-7163.22505878.v1

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Akademický článek

Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

Autor: Sebastian Brachs, Angelika F. Winkel, Hui Tang, Andreas L. Birkenfeld, Bodo Brunner, Kerstin Jahn-Hofmann, Daniel Margerie, Hartmut Ruetten, Dieter Schmoll, Joachim Spranger

Publikováno v: Molecular Metabolism, Vol 5, Iss 11, Pp 1072-1082 (2016)

Objective: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotrans

Externí odkaz: https://doaj.org/article/e5e65e2ccada43378f7614a3e68e2670

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Akademický článek

Correction: Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice.

Autor: Sebastian Brachs, Angelika F Winkel, James Polack, Hui Tang, Maria Brachs, Daniel Margerie, Bodo Brunner, Kerstin Jahn-Hofmann, Hartmut Ruetten, Joachim Spranger, Dieter Schmoll

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172657 (2017)

[This corrects the article DOI: 10.1371/journal.pone.0166110.].

Externí odkaz: https://doaj.org/article/076f5bf6ca3c49c4b9a951ee5c1b36f7

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Syntheses of Morpholine-Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization

Autor: Christiane Metz-Weidmann, Elsa Pflimlin, Kerstin Jahn-Hofmann, Ziyu Li, Bodo Brunner, Sabine Scheidler, Armin Hofmeister, Merle M Weitzenberg, Arne Krack, Mike W Helms, Oliver Plettenburg, Michael Kurz

Publikováno v: Journal of Medicinal Chemistry. 64:6838-6855

A morpholine-based nucleotide analog was developed as a building block for hepatic siRNA targeting and stabilization. Attachment of an asialoglycoprotein-binding GalNAc ligand at the morpholine nitrogen was realized with different linkers. The obtain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da575d8ed74811c57899552ba2f2ae2c
https://doi.org/10.1021/acs.jmedchem.1c00144

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Akademický článek

Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice.

Autor: Sebastian Brachs, Angelika F Winkel, James Polack, Hui Tang, Maria Brachs, Daniel Margerie, Bodo Brunner, Kerstin Jahn-Hofmann, Hartmut Ruetten, Joachim Spranger, Dieter Schmoll

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166110 (2016)

The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic dis

Externí odkaz: https://doaj.org/article/83030c9dcb7343af9651ba7750e146b5

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