Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Autor: Thomas Lindebo Holm, Ditte Tornehave, Henrik Søndergaard, Peter Helding Kvist, Bodil-Cecilie Sondergaard, Lene Hansen, Mette Brunsgaard Hermit, Kristine Holgersen, Sandra Vergo, Klaus Stensgaard Frederiksen, Claus Haase, Dorthe Lundsgaard

Publikováno v: Gastroenterology Research and Practice, Vol 2018 (2018)

Background and Aim. Interleukin-21 (IL-21) is primarily a T cell-derived cytokine; it is upregulated in patients with Crohn’s Disease (CD) and could be a potential new therapeutic target in CD. Methods. In human material, IL-21 and IL-21R expressio

Externí odkaz: https://doaj.org/article/754172b7ee274a7ea49e758f08ef3c8d

Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Autor: Maja Jakesevic, Bodil-Cecilie Sondergaard, Josué L. Castro-Mejía, Axel Kornerup Hansen, Dennis Sandris Nielsen, Peter Helding Kvist, Łukasz Krych, Thomas Lindebo Holm, Lars Hestbjerg Hansen

Publikováno v: Gastroenterology Research and Practice
Castro-Mejia, J L, Jakesevic, M, Krych, Ł, Nielsen, D S, Hansen, L H, Sondergaard, B C, Kvist, P H, Hansen, A K & Holm, T L 2016, ' Treatment with a monoclonal anti-IL-12p40 antibody induces substantial gut microbiota changes in an experimental colitis model ', Gastroenterology Research and Practice, bind 2016 . https://doi.org/10.1155/2016/4953120
Castro Mejia, J L, Jakesevic, M, Krych, L, Nielsen, D S, Hansen, L H, Sondergaard, B C, Kvist, P H, Hansen, A K & Holm, T L 2016, ' Treatment with a monoclonal anti-IL-12p40 antibody induces substantial gut microbiota changes in an experimental colitis model ', Gastroenterology Research and Practice, vol. 2016, 4953120 . https://doi.org/10.1155/2016/4953120
Gastroenterology Research and Practice, Vol 2016 (2016)

Background and Aim. Crohn’s disease is associated with gut microbiota (GM) dysbiosis. Treatment with the anti-IL-12p40 monoclonal antibody (12p40-mAb) has therapeutic effect in Crohn’s disease patients. This study addresses whether a 12p40-mAb tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec42ce7adedd57b0a2552ca5f89f8372

Application of biochemical markers in development of drugs for treatment of osteoarthritis

Autor: Anne-Christine Bay-Jensen, Bodil-Cecilie Sondergaard, Per Qvist, Suzi H Madsen, Morten A. Karsdal, Claus Christiansen

Publikováno v: Biomarkers. 15:1-19

Osteoarthritis is a chronic disease for which no efficacious medical intervention is yet available. Recent disappointments in late-stage clinical development of disease-modifying osteoarthritic drugs (DMOADs) have precipitated efforts in biomarker di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5414a003e6b9a494480925ea7b13efa
https://doi.org/10.3109/13547500903295873

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase–mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation

Autor: Suzi H Madsen, Claus Christiansen, Bodil-Cecilie Sondergaard, Amanda J. Fosang, Morten A. Karsdal, E.U. Sumer, Helle Wulf

Publikováno v: Karsdal, M A, Sumer, E U, Wulf, H, Madsen, S H, Christiansen, C, Fosang, A J & Sondergaard, B-C 2007, ' Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation ', Arthritis & Rheumatism, vol. 56, no. 5, pp. 1549-58 . https://doi.org/10.1002/art.22599

Udgivelsesdato: 2007-May OBJECTIVE: Calcitonin has been suggested to have chondroprotective effects. One signaling pathway of calcitonin is via the second messenger cAMP. We undertook this study to investigate whether increased cAMP levels in chondro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47106dd7ee98a3dd7a231ec897856189
https://doi.org/10.1002/art.22599

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model

Autor: Atkinson, Sara M., Anneline Nansen, Usher, Pernille A., Bodil-Cecilie Sondergaard, Mackay, Charles R., Friedrichsen, Birgitte, Chih-Chuan Chang, Renhong Tang, Skov, Søren, Haase, Claus, Hornum, Lars

Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4017cb5c6b7147ad93d6610d9c2c20