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RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork

Autor: Nina B. Liabakk, Geir Slupphaug, Bodil Kavli, Tobias S Obermann, Tobias S. Iveland, Lars Hagen, Edith Buchinger, Per Arne Aas, Finn Lillelund Aachmann

Publikováno v: Nucleic Acids Research

Uracil occurs at replication forks via misincorporation of deoxyuridine monophosphate (dUMP) or via deamination of existing cytosines, which occurs 2–3 orders of magnitude faster in ssDNA than in dsDNA and is 100% miscoding. Tethering of UNG2 to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1300d8e4bf01fed7c211084f636c6fac
https://pubmed.ncbi.nlm.nih.gov/33784377

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Backbone 1H, 13C and 15N chemical shift assignment of full-length human uracil DNA glycosylase UNG2

Autor: Anna Kusnierczyk, Per Arne Aas, Bodil Kavli, Renana Rabe, Finn Lillelund Aachmann, Geir Slupphaug, Siv Åshild Wiik, Edith Buchinger

Publikováno v: Biomolecular NMR Assignments. 12:15-22

Human uracil N-glycosylase isoform 2—UNG2 consists of an N-terminal intrinsically disordered regulatory domain (UNG2 residues 1–92, 9.3 kDa) and a C-terminal structured catalytic domain (UNG2 residues 93–313, 25.1 kDa). Here, we report the back

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af9ae303760a22615d0f8fc41d759b2f
https://doi.org/10.1007/s12104-017-9772-5

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Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil

Autor: Nina-Beate Liabakk, Mirta M. L. Sousa, Per Arne Aas, Robin Mjelle, Marie Benner Lundbæk, Lars Hagen, Antonio Sarno, Hans E. Krokan, Bodil Kavli

Publikováno v: Nucleic Acids Research

UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in these different processes is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb7489391aa2e45740531389b1dcc7e
https://hdl.handle.net/11250/2619516

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Robust DNA repair in PAXX-deficient mammalian cells

Autor: Khac Thanh Phong Chau, Carole Beck, Bodil Kavli, Mengtan Xing, Nina-Beate Liabakk, Raquel Gago-Fuentes, Siri Sæterstad, Per Arne Aas, Valentyn Oksenych, Alisa Elinsdatter Dewan, Marie Benner Lundbæk

Publikováno v: FEBS Open Bio

To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double-strand breaks throughout the cell cycle. NHEJ is involved in the development of B and T l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de765e211324d7b47d22a2828c8ec99f
http://hdl.handle.net/11250/2486767

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