Zobrazeno 1 - 10
of 648
pro vyhledávání: '"Bodenmiller, A."'
Autor:
Verena Hurst, Christian B. Gerhold, Cleo V. D. Tarashev, Kiran Challa, Andrew Seeber, Shota Yamazaki, Britta Knapp, Stephen B. Helliwell, Bernd Bodenmiller, Masahiko Harata, Kenji Shimada, Susan M. Gasser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Loss of cytosolic actin filaments upon TORC2 inhibition triggers chromosome fragmentation in yeast, which results from altered base excision repair of Zeocin-induced lesions. To find the link between TORC2 kinase and this yeast chromosome sh
Externí odkaz:
https://doaj.org/article/c6eea7d7981e47d3bf6b2e622889e3f4
Autor:
Rebekka Wegmann, Ximena Bonilla, Ruben Casanova, Stéphane Chevrier, Ricardo Coelho, Cinzia Esposito, Joanna Ficek-Pascual, Sandra Goetze, Gabriele Gut, Francis Jacob, Andrea Jacobs, Jack Kuipers, Ulrike Lischetti, Julien Mena, Emanuela S. Milani, Michael Prummer, Jacobo Sarabia Del Castillo, Franziska Singer, Sujana Sivapatham, Nora C. Toussaint, Oliver Vilinovszki, Mattheus H. E. Wildschut, Tharshika Thavayogarajah, Disha Malani, The TumorProfiler Consortium, Rudolf Aebersold, Marina Bacac, Niko Beerenwinkel, Christian Beisel, Bernd Bodenmiller, Viola Heinzelmann-Schwarz, Viktor H. Koelzer, Mitchell P. Levesque, Holger Moch, Lucas Pelkmans, Gunnar Rätsch, Markus Tolnay, Andreas Wicki, Bernd Wollscheid, Markus G. Manz, Berend Snijder, Alexandre P. A. Theocharides
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Deep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) wit
Externí odkaz:
https://doaj.org/article/d909919fc46044dd87b6ffb2a1e8a194
Autor:
Geethika Arekatla, Stavroula Skylaki, David Corredor Suarez, Hartland Jackson, Denis Schapiro, Stefanie Engler, Markus Auler, German Camargo Ortega, Simon Hastreiter, Andreas Reimann, Dirk Loeffler, Bernd Bodenmiller, Timm Schroeder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pluripotent mouse embryonic stem cells (ESCs) can differentiate to all germ layers and serve as an in vitro model of embryonic development. To better understand the differentiation paths traversed by ESCs committing to different lineages, we
Externí odkaz:
https://doaj.org/article/b8a1252720554a2e99b83d10ecd90a0e
Autor:
Spencer S. Watson, Benoit Duc, Ziqi Kang, Axel de Tonnac, Nils Eling, Laure Font, Tristan Whitmarsh, Matteo Massara, iMAXT Consortium, Bernd Bodenmiller, Jean Hausser, Johanna A. Joyce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The tumor microenvironment plays a crucial role in determining response to treatment. This involves a series of interconnected changes in the cellular landscape, spatial organization, and extracellular matrix composition. However, assessing
Externí odkaz:
https://doaj.org/article/eaf2eec4622b451e8d2ad39be042dd33
Autor:
Stefanie Kirchberger, Mohamed R. Shoeb, Daria Lazic, Andrea Wenninger-Weinzierl, Kristin Fischer, Lisa E. Shaw, Filomena Nogueira, Fikret Rifatbegovic, Eva Bozsaky, Ruth Ladenstein, Bernd Bodenmiller, Thomas Lion, David Traver, Matthias Farlik, Christian Schöfer, Sabine Taschner-Mandl, Florian Halbritter, Martin Distel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Neutrophils are evolutionarily conserved innate immune cells playing pivotal roles in host defense. Zebrafish models have contributed substantially to our understanding of neutrophil functions but similarities to human neutrophil maturation
Externí odkaz:
https://doaj.org/article/25da6029f28242b39dcae2b849a07a2d
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Highly multiplexed imaging enables single-cell-resolved detection of numerous biological molecules in their spatial tissue context. Interactive visualization of multiplexed imaging data is crucial at any step of data analysis to f
Externí odkaz:
https://doaj.org/article/2c7a9adba09d4aaea9f35459784eb874
Autor:
Cords, Lena, Engler, Stefanie, Haberecker, Martina, Rüschoff, Jan Hendrik, Moch, Holger, de Souza, Natalie, Bodenmiller, Bernd
Publikováno v:
In Cancer Cell 11 March 2024 42(3):396-412
Autor:
Stefanie Hiltbrunner, Lena Cords, Sabrina Kasser, Sandra N. Freiberger, Susanne Kreutzer, Nora C. Toussaint, Linda Grob, Isabelle Opitz, Michael Messerli, Martin Zoche, Alex Soltermann, Markus Rechsteiner, Maries van den Broek, Bernd Bodenmiller, Alessandra Curioni-Fontecedro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint inhibitor treatment has the potential to prolong survival in non-small cell lung cancer (NSCLC), however, some of the patients develop resistance following initial response. Here, we analyze the immune phenotype of matching
Externí odkaz:
https://doaj.org/article/c99e4e76f6b544649dae1c58e4b5b5c4
Autor:
Lena Cords, Sandra Tietscher, Tobias Anzeneder, Claus Langwieder, Martin Rees, Natalie de Souza, Bernd Bodenmiller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Cancer-associated fibroblasts (CAFs) are a diverse cell population within the tumour microenvironment, where they have critical effects on tumour evolution and patient prognosis. To define CAF phenotypes, we analyse a single-cell RNA sequenc
Externí odkaz:
https://doaj.org/article/e895f82d4db8449c83560249a1b3faa7
Autor:
Sandra Tietscher, Johanna Wagner, Tobias Anzeneder, Claus Langwieder, Martin Rees, Bettina Sobottka, Natalie de Souza, Bernd Bodenmiller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
T cell exhaustion in breast tumours remains to be fully characterised. Here, single cell transcriptomics and imaging mass cytometry analysis of luminal breast tumours with or without exhausted T cells suggests distinct patterns of PD-1 and CXCL13 exp
Externí odkaz:
https://doaj.org/article/08f5d97e823a4685b87f430c9ee08e84