An interdisciplinary analysis of inflammatory signalling dynamics in single cells

Autor: Boddington, Christopher

Immune cells must accurately interpret environmental signals to make robust cell fate decisions and control inflammatory signalling. Many signals (e.g. Tumor Necrosis Factor alpha (TNFα) or interferon gamma (IFNγ)) converge on just a few key signal

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.764321

Integration of kinase and calcium signaling at 1 the level of chromatin underlies inducible gene activation in T cells

Autor: Brignall, Ruth, Cauchy, Pierre, Bevington, Sarah L. Bevington, Gorman, Bethany, Pisco, Angela O., Bagnall, James, Boddington, Christopher, Rowe, William, England, Hazel, Rich, Kevin, Schmidt, Lorraine, Dyer, Nigel P., Travis, Mark, Ott, Sascha, Jackson, Dean, Cockerill, Peter N, Paszek, Pawel

Publikováno v: Brignall, R, Cauchy, P, Bevington, S L B, Gorman, B, Pisco, A O, Bagnall, J, Boddington, C, Rowe, W, England, H, Rich, K, Schmidt, L, Dyer, N P, Travis, M, Ott, S, Jackson, D, Cockerill, P N & Paszek, P 2017, ' Integration of kinase and calcium signaling at 1 the level of chromatin underlies inducible gene activation in T cells ', Journal of Immunology, vol. 199, no. 8, pp. 2652-2667 . https://doi.org/10.4049/jimmunol.1602033

TCR signaling pathways cooperate to activate the inducible transcription factors NF-B, NFAT and AP-1. Here, using the calcium ionophore ionomycin and/or PMA on Jurkat T cells, we show that the gene expression program associated with activation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::b04306a309407541134a4d09bcabd2c6
https://www.research.manchester.ac.uk/portal/en/publications/integration-of-kinase-and-calcium-signaling-at-1-the-level-of-chromatin-underlies-inducible-gene-activation-in-t-cells(48bfa383-80db-40cb-a601-511aecdeb968).html

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