CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Autor: Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Ruiz, Eva Daniela, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A., Simmons, Camilla, Cash, Diana, Richardson, Jill, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Correia, Marta M., Crofts, Anna L., Dickinson, Amber, Foster, Andrew C., Kitzbichler, Manfred G., Knight, Clare, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda J., Hyslop, Peter St. George, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Touchard, Samuel, Cavanagh, Jonathan, Deith, Catherine, Farmer, Scott, McClean, John, McColl, Alison, McPherson, Andrew, Scouller, Paul, Sutherland, Murray, Boddeke, H. W. G. M. (Erik), Richardson, Jill C., Khan, Shahid, Murphy, Phil, Patel, Jai, Jones, Declan, de Boer, Peter, Kemp, John, Drevets, Wayne C., Nye, Jeffrey S., Wittenberg, Gayle, Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Turkheimer, Federico, Barker, Gareth J., Byrom, Heidi, Cattaneo, Annamaria, Gee, Antony, Hastings, Caitlin, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Randall, Karen, Sheridan, Hannah, Singh, Nisha, VAn Loo, Victoria, Wood, Tobias C, Worrell, Courtney, Zajkowska, Zuzanna, Plath, Niels, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Thomsen, Christian, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Hurley, Samuel, Jones, Helen, Lovestone, Simon, Mada, Francisca, Nevado-Holgado, Alejo, Oladejo, Akintayo, Smith, Katy, Vyas, Anviti, Hughes, Zoe, Balice-Gordon, Rita, Duerr, James, Piro, Justin R, Sporn, Jonathan, Perry (PI), V Hugh, Gomez-Nicola, Diego, Reynolds, Richard, Harrison, Neil A., Cercignani, Mara, Clarke, Charlotte L, Hoskins, Elizabeth, Kohn, Charmaine, Murray, Rosemary, Wilcock, Lauren, Wlazly, Dominika, Mount, Howard, Jones, Declan N. C., Perry, V. Hugh

Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s disease, and experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::51ba1226d0cdf9b948ae30e9b823a15b
https://orca.cardiff.ac.uk/id/eprint/125159/7/awz241.pdf

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

Autor: Jansen, Anne H. P., van Hal, Maurik, Op den Kelder, Ilse C., Meier, Romy T., de Ruiter, Anna-Aster, Schut, Menno H., Smith, Donna L., Grit, Corien, Brouwer, Nieske, Kamphuis, Willem, Boddeke, H. W. G. M., den Dunnen, Wilfred F. A., van Roon, Willeke M. C., Bates, Gillian P., Hol, Elly M., Reits, Eric A.

Publikováno v: GLIA, 65, 50-61. John Wiley and Sons Inc.
Glia, 65(1), 50-61. Wiley
Glia, 65(1), 50-61. John Wiley and Sons Inc.

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion formation in the brain. The mutant huntingtin protein (mHTT) is ubiquitou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0387328b88b415234f036c81830e572c
https://pure.knaw.nl/portal/en/publications/80861db7-6e52-4c3d-b34c-c624dc737800

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR

Autor: Vinet, J., van Zwam, M., Dijkstra, I. M., Brouwer, N., van Weering, H. R. J., Watts, A., Meijer, M., Fokkens, M. R., Kannan, V., Verzijl, D., Vischer, H. F., Smit, M. J., Leurs, R., Biber, K., Boddeke, H. W. G. M.

Publikováno v: British Journal of Pharmacology, 168(6), 1375-1387. Wiley-Blackwell

Background and Purpose Induction of cellular migration is the primary effect of chemokine receptor activation. However, several chemokine receptor-like proteins bind chemokines without subsequent induction of intracellular signalling and chemotaxis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::933774aa716d16d94f2443915bd171f8
https://pubmed.ncbi.nlm.nih.gov/23121557

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