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Autor:
Alan K. Mallams, Randall R. Rossman, Ronald J. Doll, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Joanne Petrin, Lynn Wang, Robert Patton, W. Robert Bishop, Donna M. Carr, Paul Kirschmeier, Joseph J. Catino, Matthew S. Bryant, Kwang-Jong Chen, Walter A. Korfmacher, Cymbelene Nardo, Shiyong Wang, Amin A. Nomeir, Chin-Chung Lin, Zujun Li, Jianping Chen, Suining Lee, Janet Dell, Philip Lipari, Michael Malkowski, Bodan Yaremko, Ivan King, Ming Liu
Publikováno v:
Journal of Medicinal Chemistry. 41:877-893
The synthesis of a variety of novel 4-amido, 4-carbamoyl and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine to explore the SAR of of this series of FPT inhibitors is described. This result