Selective cytotoxicity of arene tricarbonylchromium towards tumour cell lines

Autor: Sami Mnif, Siden Top, Nejmeddine Akacha, Bochra Hakim, Sami Aifa, Gérard Jaouen, Jihene Elloumi-Mseddi, Pascal Pigeon

Publikováno v: Journal of Organometallic Chemistry
Journal of Organometallic Chemistry, Elsevier, 2018, 862, pp.7-12. ⟨10.1016/j.jorganchem.2018.01.036⟩

International audience; Metals are cytotoxic and could be harmful to human health; however, as their effects are dose dependant, some of them could be used in chemotherapy. In the present work, mineral chromium (VI) showed that it is cytotoxic on bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3764bdde7334f4a48f79c67b8733749
https://doi.org/10.1016/j.jorganchem.2018.01.036

A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family

Autor: Melek Mnejja, Mariem Ben Said, Ayda Khalfallah, Zeineb Benzina, Ignacio del Castillo, Khalil Turki, Leila Ayedi, Bochra Hakim, Mounira Hmani Aifa, Abdelmonem Ghorbel, Hammadi Ayadi, Ilhem Charfeddine, Saber Masmoudi, Chamseddine Khifagi

Publikováno v: European Journal of Medical Genetics. 54:e535-e541

Autosomal recessive non-syndromic hearing loss (ARNSHL) is a genetically heterogenous disorder with 41 genes so far identified. Among these genes, ESRRB whose mutations are responsible for DFNB35 hearing loss in Pakistani and Turkish families. This g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455349c487509409a3eb3780be26f8f8
https://doi.org/10.1016/j.ejmg.2011.06.008

A novel dominant mutation in SIX1, affecting a highly conserved residue, result in only auditory defects in humans

Autor: Saber Masmoudi, J. Mnif, Leila Dhouib, Leila Ayadi, Mohamed Ali Mosrati, Ilhem Charfeddine, B. Hammami, Imen Ben Rebeh, Khaireddine Ben mahfoudh, Abdelmonem Ghorbel, Bochra Hakim

Publikováno v: European Journal of Medical Genetics. 54:e484-e488

Branchio-oto-renal (BOR) and Branchio-otic (BO) syndromes are dominant disorders characterized by variable hearing impairment (HI) and branchial defects. BOR includes additional kidney malformations. BO/BOR syndromes are genetically heterogeneous and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b87460a58d8e31f991ac9ba34b6e315
https://doi.org/10.1016/j.ejmg.2011.06.001

Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice

Autor: Ileana Soto, Danilo G. Macalinao, K. Saidas Nair, I. M. Cosma, Hammadi Ayadi, Peter Söderkvist, Bochra Hakim, Salma Ben Salem, Mounira Hmani-Aifa, Zain Ali, Walid Bouassida, Gareth R. Howell, Alison L. Kearney, Simon W. M. John, Richard S. Smith, Zeineb Benzina

Publikováno v: Nature Genetics. 43:579-584

Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people. Although 4 million people are bilaterally blind from ACG, the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d949428867839ef3568facfb72356f
https://doi.org/10.1038/ng.813

Association of COL1A1 and TGFB1 polymorphisms with otosclerosis in a Tunisian population

Autor: Ayda, Khalfallah, Isabelle, Schrauwen, Malek, Mnejja, Hassen, HadjKacem, Leila, Dhouib, Mohamed Ali, Mosrati, Bochra, Hakim, Imed, Lahmar, Ilhem, Charfeddine, Nabil, Driss, Hammadi, Ayadi, Abdelmonem, Ghorbel, Guy, Van Camp, Saber, Masmoudi

Publikováno v: Annals of human genetics. 75(5)

Otosclerosis is a condition characterized by an abnormal bone metabolism in the otic capsule, resulting in conductive and/or sensorineural hearing loss. Otosclerosis is a common disorder in which genes play an important role. Case-control association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f80b8c13c3e01526a9420077e510307
https://pubmed.ncbi.nlm.nih.gov/21777208