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iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse

Autor: Xiao-Yu Zhao, Samantha L. Lempke, Jan C. Urbán Arroyo, Isabel G. Brown, Bocheng Yin, Magdalena M. Magaj, Nadia K. Holness, Jamison Smiley, Stefanie Redemann, Sarah E. Ewald

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Toxoplasma gondii is an obligate intracellular parasite of rodents and humans. Interferon-inducible guanylate binding proteins (GBPs) are mediators of T. gondii clearance, however, this mechanism is incomplete. Here, using automated spatiall

Externí odkaz: https://doaj.org/article/6d37669bd768444090335bf5da6cab31

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Automated Spatially Targeted Optical Microproteomics Investigates Inflammatory Lesions In Situ

Autor: Emily C. McGowan, Rung-chi Li, Bocheng Yin, Laura R. Caggiano, Sarah E. Ewald, Jeffrey W. Holmes

Publikováno v: J Proteome Res

Tissue microenvironment properties like blood flow, extracellular matrix, or proximity to immune-infiltrate are important regulators of cell biology. However, methods to study regional protein expression in the native tissue environment are limited.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deb76386f3743709c81ee495abc77dd
https://doi.org/10.1021/acs.jproteome.1c00505

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Automated Spatially Targeted Optical Microproteomics (autoSTOMP) to Determine Protein Complexity of Subcellular Structures

Autor: Ku-Lung Hsu, Sarah E. Ewald, Rishi Rakhit, Bocheng Yin, Roberto Mendez, Xiao-Yu Zhao

Publikováno v: Analytical Chemistry. 92:2005-2010

Spatially targeted optical microproteomics (STOMP) is a method to study region-specific protein complexity in primary cells and tissue samples. STOMP uses a confocal microscope to visualize structu...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eca5e8f6bd42f91a2fe63b7cc97bd6da
https://doi.org/10.1021/acs.analchem.9b04396

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Automated Spatially Targeted Optical Micro Proteomics (AutoSTOMP) 2.0 identifies proteins enriched within inflammatory lesions in tissue sections and human clinical biopsies

Autor: Rung-chi Li, Emily C. McGowan, Bocheng Yin, Sarah E. Ewald, Laura R. Caggiano, Jeffrey W. Holmes

Tissue microenvironment properties like blood flow, extracellular matrix or proximity to immune infiltrate are important regulators of cell biology. However, methods to study regional protein expression in context of the native tissue environment are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c78af44dfca1cc8cc73cbbdc1c5c36
https://doi.org/10.1101/2021.03.19.436192

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TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus

Autor: Gabriel Herrrera-López, Bocheng Yin, Carolina Tecuatl, Stephen G. Weber, German Barrionuevo, Alejandro Martín-Ávila, Emilio J. Galván

Publikováno v: European Journal of Neuroscience. 47:1096-1109

The selective vulnerability of hippocampal area CA1 to ischemia-induced injury is a well-known phenomenon. However, the cellular mechanisms that confer resistance to area CA3 against ischemic damage remain elusive. Here, we show that oxygen-glucose d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9ff50b091c3c306d615b2a30457b57
https://doi.org/10.1111/ejn.13880

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Automated Spatially Targeted Optical Micro Proteomics (autoSTOMP) to determine protein complexity of subcellular structures

Autor: Sarah E. Ewald, Rishi Rakhit, Roberto Mendez, Bocheng Yin, Xiao-Yu Zhao, Ku-Lung Hsu

Spatially Targeted Optical Micro Proteomics (STOMP) is a method to study region-specific protein complexity of a biological specimen. STOMP uses a confocal microscope to both visualize structures of interest and to tag the proteins within those struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845ba18f191c024fef0de80364b61b86

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Micro-structure Proteins Characterization in Tissue Sections and Clinical Biopsy Samples by a Novel Spatial Proteomic Method Named AutoSTOMP

Autor: Bocheng Yin, Sarah Ewald, Jeff Holmes, Emily McGowan

Publikováno v: The Journal of Immunology. 206:27.01-27.01

We aim at structure determining immunological machinery using a novel spatial selective proteomic tool, autoSTOMP, developed in Ewald lab. AutoSTOMP comprises of UV initiated biotin tagging by confocal microscopy, affinity isolation, and peptide iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34c551a3f39a13ee58f09c2d0b0db6ba
https://doi.org/10.4049/jimmunol.206.supp.27.01

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Cell death effectors are recruited to Toxoplasma gondii parasite vacuoles targeted by interferon-inducible GTPases in infected dendritic cells

Autor: Xiaoyu Zhao, Bocheng Yin, Sarah E. Ewald

Publikováno v: The Journal of Immunology. 206:110.04-110.04

Toxoplasma gondii is an obligate intracellular pathogen whose ability to grow and evade cell autonomous immunity depends on the parasitophorous vacuole membrane (PVM). The PVM forms from the host plasma membrane during invasion and is maintained by p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f33c8903bf53cb5e2490e1af4cc8b12d
https://doi.org/10.4049/jimmunol.206.supp.110.04

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