Serum iron levels and the risk of Parkinson Disease: a Mendelian randomization study

Autor: Pichler I, Del Greco M. F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH, PD GWAS Consortium, Nalls M, Keller MF, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield JB, Genetics of Iron Status Consortium, Pramstaller PP, Hicks AA, Thompson JR, Minelli C., Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón Sánchez J, Schulte C, Lesage S, Arepalli S, Barker R, Ben Shlomo Y, Berendse HW, Berg D, Bhatia K, de Bie RM, Biffi A, Bloem B, Bochdanovits Z, Bonin M, Bras JM, Brockmann K, Brooks J, Burn DJ, Charlesworth G, Chen H, Chinnery PF, Chong S, Clarke CE, Cookson MR, Cooper JM, Corvol JC, Counsell C, Damier P, Dartigues JF, Deloukas P, Deuschl G, Dexter DT, van Dijk KD, Dillman A, Durif F, Dürr A, Edkins S, Evans JR, Foltynie T, Gao J, Gardner M, Gibbs JR, Goate A, Gray E, Guerreiro R, Harris C, van Hilten JJ, Hofman A, Hollenbeck A, Holton J, Hu M, Huang X, Huber H, Hudson G, Hunt SE, Illig T, Lambert JC, Langford C, Lees A, Lichtner P, Limousin P, Lopez G, Lorenz D, McNeill A, Moorby C, Moore M, Morris HR, Morrison KE, Mudanohwo E, O'Sullivan SS, Pearson J, Perlmutter JS, Pollak P, Post B, Potter S, Ravina B, Revesz T, Riess O, Rivadeneira F, Rizzu P, Ryten M, Sawcer S, Schapira A, Scheffer H, Shaw K, Shoulson I, Sidransky E, Smith C, Spencer CC, Stockton JD, Strange A, Talbot K, Tanner CM, Tashakkori Ghanbaria A, Trabzuni D, Traynor BJ, Uitterlinden AG, Velseboer D, Vidailhet M, Walker R, van de Warrenburg B, Wickremaratchi M, Williams N, Williams Gray CH, Winder Rhodes S, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW, Donnelly P, Barroso I, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Band G, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Pearson R, Su Z, Vukcevic D, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Hammond N, Jayakumar A, McCann OT, Liddle J, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, McCarthy MI, Ouwehand WH, Radhakrishnan A, Sambrook J, Toniolo D, Camaschella C, Metspalu A, Esko T, Gieger C, Ried J, Meitinger T, Oexle K, Winkelmann J, Swinkels D, Vermeulen S, van Duijn C, Broer L, Beilby J, Hui J, Anderson D, Visscher P, Martin N., TRAGLIA, MICHELA

Publikováno v: Pichler, I, Del Greco, M F, Gögele, M, Lill, C M, Bertram, L, Do, C B, Eriksson, N, Foroud, T, Myers, R H, Benyamin, B, Withfield, J B, Pramstaller, P P, Hicks, A A, Thompson, J R, Minelli, C & Bochdanovits, Z 2013, ' Serum iron levels and the risk of Parkinson disease: a mendelian randomization study ', PLoS Medicine, vol. 10, no. 6, e1001462, pp. 1-13 . https://doi.org/10.1371/journal.pmed.1001462
PLOS Medicine, Vol. 10, No 6 (2013) P. e1001462
PLoS Medicine, 10(6):e1001462, 1-13. Nature Publishing Group
PLoS Medicine, Vol 10, Iss 6, p e1001462 (2013)
PLoS Medicine, 10(6):e1001462, 1-13. Public Library of Science
PLoS medicine, 10(6). Public Library of Science
PLoS Medicine

In this study, Mendelian randomization was used to study genes known to modify iron levels, and the effect of iron on Parkinson's disease (PD) risk was estimated. Based on estimates of the genetic effects on both iron and PD obtained from the largest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1ff83d9ac49e91aea223736fdcdb62
https://hdl.handle.net/11541.2/130162

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

Autor: Witoelar, A.W., Jansen, I.E., Wang, Y., Desikan, R.S., Gibbs, J.R., Blauwendraat, C., Thompson, W.K., Hernandez, D.G., Djurovic, S., Schork, A.J., Bettella, F., Ellinghaus, D., Franke, A., Lie, B.A., McEvoy, L.K., Karlsen, T.H., Lesage, S., Morris, H.R., Brice, A., Wood, N.W., Heutink, P., Hardy, J., Singleton, A.B., Dale, A.M., Gasser, T., Andreassen, O.A., Sharma, M., Nalls, M.A., Plagnol, V., Sheerin, U.M., Saad, M., Simon-Sanchez, J., Schulte, C., Sveinbjörnsdóttir, S., Arepalli, S., Barker, R.A., Ben-Shlomo, Y., Berendse, H.W., Berg, D., Bhatia, K.P., de Bie, R.M.A., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Bras, J.M., Brockmann, K., Brooks, J.M., Burn, D.J., Majounie, E., Illig, T., Lichtner, P., Weale, M.E.

Publikováno v: JAMA Neurol. 74, 780-792 (2017)
JAMA neurology, vol 74, iss 7
Witoelar, A, Jansen, I E, Wang, Y, Desikan, R S, Gibbs, J R, Blauwendraat, C, Thompson, W K, Hernandez, D G, Djurovic, S, Schork, A J, Bettella, F, Ellinghaus, D, Franke, A, Lie, B A, McEvoy, L K, Karlsen, T H, Lesage, S, Morris, H R, Brice, A, Wood, N W, Heutink, P, Hardy, J, Singleton, A B, Dale, A M, Gasser, T, Andreassen, O A, Sharma, M & or the International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators 2017, ' Genome-wide pleiotropy between Parkinson disease and autoimmune diseases ', JAMA Neurology, vol. 74, no. 7, pp. 780-792 . https://doi.org/10.1001/jamaneurol.2017.0469
JAMA Neurology, 74(7), 780-792. American Medical Association
JAMA neurology 74(7), 780 (2017). doi:10.1001/jamaneurol.2017.0469

Importance Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cd9b818e36d8b3ee3e640b6a72faa7
https://doi.org/10.1001/jamaneurol.2017.0469

Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder.

Autor: Bochdanovits, Z.¹ z.bochdanovits@vumc.nl, Verhage, M.², Smit, A. B.³, de Geus, E. J. C.⁴, Posthuma, D.^1,4, Boomsma, D. I.⁴, Penninx, B. W. J. H.⁵, Hoogendijk, W. J.⁵, Heutink, P.¹

Publikováno v: Molecular Psychiatry. Jul2009, Vol. 14 Issue 7, p650-652. 3p. 2 Graphs.

Estimating and testing linkage disequilibrium from sib data

Autor: Jonker, M.A., van der Vaart, A.W., Bochdanovits, Z., Boomsma, D.I.

Publikováno v: Statistica Neerlandica. Journal of the Netherlands Society for Statistics and Operations Research, 65(3), 239-258. Wiley-Blackwell
Jonker, M A, van der Vaart, A W, Bochdanovits, Z & Boomsma, D I 2011, ' Estimating and testing linkage disequilibrium from sib data ', Statistica Neerlandica. Journal of the Netherlands Society for Statistics and Operations Research, vol. 65, no. 3, pp. 239-258 . https://doi.org/10.1111/j.1467-9574.2011.00480.x

We consider estimation and testing of linkage equilibrium from genotypic data on a random sample of sibs, such as monozygotic and dizygotic twins. We compute the maximum likelihood estimator with an EM-algorithm and a likelihood ratio statistic that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f7012d00d727e1f3cb037a9cbad2e86
https://research.vumc.nl/en/publications/ebc59d77-f681-4954-82fd-d6452cf49335

The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive-compulsive disorder (OCD)

Autor: Katerberg, H., Lochner, C., de Jonge, P., Bochdanovits, Z., Moolman-Smook, J.C., Hemmings, S.M., Carey, P.D., Stein, D.J., Sondervan, D., den Boer, J.A., van Balkom, A.J., Polman, A., Heutink, P.

Publikováno v: American Journal of Medical Genetics part B-Neuropsychiatric Genetics, 150B(8), 1050-1062. Wiley-Liss Inc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::36bff94e6650b86301b62af419086258
https://research.tilburguniversity.edu/en/publications/06f476f4-c4e2-4b04-8455-293156ee56fd