Unraveling the Mechanism of Platelet Aggregation Suppression by Thioterpenoids: Molecular Docking and In Vivo Antiaggregant Activity.

Autor: Nikitina LE; General and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia.; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia., Bocharov PS; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia., Ksenofontov AA; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia.; Department of Inorganic Chemistry, Ivanovo State University of Chemistry and Technology, 153045 Ivanovo, Russia., Antina EV; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia., Gilfanov IR; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.; Varnishes and Paints Coatings Department, Kazan National Research Technological University, 420015 Kazan, Russia., Pavelyev RS; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia., Ostolopovskaya OV; General and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia.; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia., Fedyunina IV; General and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia., Azizova ZR; General and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia., Pestova SV; Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 167000 Syktyvkar, Russia., Izmest'ev ES; Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 167000 Syktyvkar, Russia., Rubtsova SA; Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 167000 Syktyvkar, Russia., Boichuk SV; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.; Department of Pathology, Kazan State Medical University, 420012 Kazan, Russia.; Department of Radiotherapy and Radiology, Russian Medical Academy of Continuous Professional Education, 125993 Moscow, Russia., Galembikova AR; Department of Pathology, Kazan State Medical University, 420012 Kazan, Russia., Smolyarchuk EA; Department of Pharmacology, Sechenov First Moscow State Medical University (Sechenov University), 125993 Moscow, Russia., Mustafin IG; Biochemistry Department, Kazan State Medical University, 420012 Kazan, Russia., Kayumov AR; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia., Samorodov AV; Department of Pharmacology, Bashkir State Medical University, 450008 Ufa, Russia.

Publikováno v: Biomimetics (Basel, Switzerland) [Biomimetics (Basel)] 2023 Nov 27; Vol. 8 (8). Date of Electronic Publication: 2023 Nov 27.

Thioterpenoids as Potential Antithrombotic Drugs: Molecular Docking, Antiaggregant, Anticoagulant and Antioxidant Activities.

Autor: Ksenofontov AA; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia.; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia., Bocharov PS; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia., Antina EV; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia., Shevchenko OG; Center of Collective Usage «Molecular Biology», Institute of Biology, Komi Science Centre, Ural Branch of Russian Academy of Sciences, 28 Kommunisticheskaya Street, 167982 Syktyvkar, Russia., Samorodov AV; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; Department of Pharmacology, Bashkir State Medical University, 3 Lenina str., 450008 Ufa, Russia., Gilfanov IR; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; Varnishes and Paints Department, Kazan National Research Technological University, 68 K. Marksa Street, 420015 Kazan, Russia., Pavelyev RS; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia., Ostolopovskaya OV; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia., Startseva VA; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia., Fedyunina IV; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia., Azizova ZR; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia., Gaysin SI; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia., Pestova SV; Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 48 Pervomaiskaya Street, 167000 Syktyvkar, Russia., Izmest'ev ES; Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 48 Pervomaiskaya Street, 167000 Syktyvkar, Russia., Rubtsova SA; Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 48 Pervomaiskaya Street, 167000 Syktyvkar, Russia., Khelkhal MA; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia., Nikitina LE; Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia.; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia.

Publikováno v: Biomolecules [Biomolecules] 2022 Oct 30; Vol. 12 (11). Date of Electronic Publication: 2022 Oct 30.

Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking.

Autor: Guseva GB; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia. Electronic address: gbg@isc-ras.ru., Antina EV; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia., Berezin MB; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia., Ksenofontov AA; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia., Bocharov PS; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia; Ivanovo State University of Chemistry and Technology, 7, Sheremetevskiy Avenue, 153000 Ivanovo, Russia., Smirnova AS; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia; Ivanovo State University of Chemistry and Technology, 7, Sheremetevskiy Avenue, 153000 Ivanovo, Russia., Pavelyev RS; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia., Gilfanov IR; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Pestova SV; Institute of Chemistry, Federal Research Center 'Komi Scientific Centre', Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 48, 167000 Syktyvkar, Russia., Izmest'ev ES; Institute of Chemistry, Federal Research Center 'Komi Scientific Centre', Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 48, 167000 Syktyvkar, Russia., Rubtsova SA; Institute of Chemistry, Federal Research Center 'Komi Scientific Centre', Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 48, 167000 Syktyvkar, Russia., Kayumov AR; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia., Kiselev SV; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Azizova ZR; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Ostolopovskaya OV; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia., Efimov SV; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia., Klochkov VV; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia., Khodov IA; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia., Nikitina LE; Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia; Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia.

Publikováno v: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2022 Mar 05; Vol. 268, pp. 120638. Date of Electronic Publication: 2021 Nov 18.

Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids.

Autor: Nikitina LE; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Pavelyev RS; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Gilfanov IR; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Kiselev SV; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Azizova ZR; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Ksenofontov AA; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia., Bocharov PS; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia.; Faculty of Fundamental and Applied Chemistry, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskiy av., 153000 Ivanovo, Russia., Antina EV; G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, 1 Akademicheskaya st., 153045 Ivanovo, Russia., Klochkov VV; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Timerova AF; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Rakhmatullin IZ; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Ostolopovskaya OV; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia.; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Khelkhal MA; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia., Boichuk SV; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Galembikova AR; General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova st., 420012 Kazan, Russia., Andriutsa NS; Institute of the Biological Design and Modelling of Complex Systems, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, md. Edalgo 7, apt. 219, 108801 Moscow, Russia., Frolova LL; Institute of Chemistry, Federal Research Center, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Pervomayskaya st. 48, 167982 Syktyvkar, Russia., Kutchin AV; Institute of Chemistry, Federal Research Center, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Pervomayskaya st. 48, 167982 Syktyvkar, Russia., Kayumov AR; Medical Physics Department, Kazan Federal University, 18 Kremlyovskaya st., 420008 Kazan, Russia.

Publikováno v: Bioengineering (Basel, Switzerland) [Bioengineering (Basel)] 2022 Jan 10; Vol. 9 (1). Date of Electronic Publication: 2022 Jan 10.