High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients

Autor: Annabella Di Mauro, Mariachiara Santorsola, Giovanni Savarese, Roberto Sirica, Monica Ianniello, Alessia Maria Cossu, Anna Ceccarelli, Francesco Sabbatino, Marco Bocchetti, Anna Chiara Carratù, Francesca Pentimalli, Gerardo Ferrara, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-11 (2024)

Abstract Background Microsatellite instability (MSI) is a well-established predictive biomarker for immune checkpoint inhibitor (ICI) response in metastatic colon cancer. Both high MSI and tumor mutational burden (TMB) are markers of genomic instabil

Externí odkaz: https://doaj.org/article/2511af399ba9499ab479b1e841ab980d

Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer.

Autor: Bocchetti, Marco^1,2 (AUTHOR) marco.bocchetti@unicampania.it, Luce, Amalia¹ (AUTHOR), Iannarone, Clara^1,2 (AUTHOR), Pasquale, Lucia Stefania^1,2 (AUTHOR), Falco, Michela¹ (AUTHOR), Tammaro, Chiara¹ (AUTHOR), Abate, Marianna^1,2 (AUTHOR), Ferraro, Maria Grazia³ (AUTHOR), Addeo, Raffaele⁴ (AUTHOR), Ricciardiello, Filippo⁵ (AUTHOR), Motta, Giovanni⁵ (AUTHOR), De Stefano, Luca⁶ (AUTHOR), Caraglia, Francesco⁷ (AUTHOR), Ceccarelli, Anna⁸ (AUTHOR), Zappavigna, Silvia¹ (AUTHOR), Scrima, Marianna^2,9 (AUTHOR), Cossu, Alessia Maria^1,2 (AUTHOR), Caraglia, Michele^1,2 (AUTHOR), Misso, Gabriella¹ (AUTHOR) gabriella.misso@unicampania.it

Publikováno v: Journal of Translational Medicine. 6/20/2024, Vol. 22 Issue 1, p1-9. 9p.

Sezione V; decisione 12 maggio 1937; Pres. Fagiolari P., Est. Caruso; Comune di Novara (Avv. Bocchetti, Devecchi, Frascotti) c. Ministero interno, Comune di Padova (Avv. Tonzig) e Ospedale civile di Padova

Publikováno v: Il Foro Italiano, 1937 Jan 01. 62, 285/286-287/288.

Externí odkaz: https://www.jstor.org/stable/23131955

Evolution of Thoracic Disc Herniation Surgery: Future Perspectives from a Systematic Review and Meta-Analysis

Autor: Giuseppe Corazzelli, Sergio Corvino, Giulio Di Noto, Chiara Di Domenico, Federico Russo, Giuseppe Mariniello, Andrea Elefante, Antonio Bocchetti, Sergio Paolini, Vincenzo Esposito, Gualtiero Innocenzi, Raffaele de Falco, Oreste de Divitiis

Publikováno v: Brain Sciences, Vol 14, Iss 11, p 1062 (2024)

Background: The neurosurgical treatment of thoracic disc herniation (TDH) has undergone dramatic changes over the years in terms of surgical approaches and intraoperative technological tools. There is still no unanimous consent on the criteria for ap

Externí odkaz: https://doaj.org/article/85ea904f78414daca331a52e9ec805f8

Whole-genome analysis suggesting probiotic potential and safety properties of Pediococcus pentosaceus DSPZPP1, a promising LAB strain isolated from traditional fermented sausages of the Basilicata region (Southern Italy)

Autor: Madhura S. Tathode, Maria Grazia Bonomo, Silvia Zappavigna, Stefania Mirela Mang, Marco Bocchetti, Ippolito Camele, Michele Caraglia, Giovanni Salzano

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

IntroductionMany lactic acid bacteria (LAB) strains are currently gaining attention in the food industry and various biological applications because of their harmless and functional properties. Given the growing consumer demand for safe food, further

Externí odkaz: https://doaj.org/article/3ee5a06ecce344bdbe6f41a9db9f56d6