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NAD⁺ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.

Autor: Franza, Thierry, Rogstam, Annika, Thiyagarajan, Saravanamuthu, Sullivan, Matthew J., Derré-Bobillot, Aurelie, Bauer, Mikael C., Goh, Kelvin G. K., Da Cunha, Violette, Glaser, Philippe, Logan, Derek T., Ulett, Glen C., von Wachenfeldt, Claes, Gaudu, Philippe

Publikováno v: PLoS Pathogens; 8/9/2021, Vol. 17 Issue 8, p1-27, 27p

Visualization of the role of host heme on the virulence of the heme auxotroph Streptococcus agalactiae

Autor: Joubert, Laétitia, Dagieu, Jean-Baptiste, Fernandez, Annabelle, Bobillot, Aurelie, Borezée-Durant, Elise, Fleurot, Isabelle, Gruss, Alexandra, Lechardeur, Delphine

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.40435. ⟨10.1038/srep40435⟩
Scientific Reports, Nature Publishing Group, 2017, 7, 13 p. ⟨10.1038/srep40435⟩

International audience; Heme is essential for several cellular key functions but is also toxic. Whereas most bacterial pathogens utilize heme as a metabolic cofactor and iron source, the impact of host heme during bacterial infection remains elusive.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b1586c9c8657463dea63fdffb943bca2
https://hal.archives-ouvertes.fr/hal-01594946/document

A partial metabolic pathway enables group b streptococcus to overcome quinone deficiency in a host bacterial community

Autor: Franza, Thierry, Delavenne, Emilie, Derre-Bobillot, Aurelie, Juillard, Vincent, Boulay, Mylène, Demey, Emmanuelle, Vinh, Joelle, Lamberet, Gilles, Gaudu, Philippe

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2016, 102 (1), pp.81-91. ⟨10.1111/mmi.13447⟩
Molecular Microbiology, Wiley, 2016, ⟨10.1111/mmi.13447⟩

International audience; Aerobic respiration metabolism in Group B Streptococcus (GBS) is activated by exogenous heme and menaquinone. This capacity enhances resistance of GBS to acid and oxidative stress and improves its survival. In this work, we di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7dd33652c99a5c3d44fa57c57f51591b
https://hal.archives-ouvertes.fr/hal-01412645