Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bobbe L. Ferraiolo"'
Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents. In addition, the development and improvement of analytical techniqu
Autor:
Barbara Moffat, Michael Roth, Paul A. Cossum, Sharon A. Chen, Bobbe L. Ferraiolo, Kevin A. Dwyer, Richard Vandlen
Publikováno v:
Pharmaceutical Research. :419-424
The pharmacokinetics and tissue distribution of a human relaxin were investigated after intravenous (iv) bolus administration to pregnant or nonpregnant rats. Human gene-2 relaxin (hRlx-2) serum concentrations after iv bolus administration were descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::810ee63de30141219dfa1cd5886bc75c
https://doi.org/10.1023/a:1015863507496
https://doi.org/10.1023/a:1015863507496
Publikováno v:
Pharmaceutical Research. :1351-1359
The clearance and volume of distribution of five human proteins (recombinant CD4, CD4 immunoglobulin G, growth hormone, tissue-plasminogen activator, and relaxin) in humans and laboratory animals were analyzed as a function of body weight using allom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb5f2d262dac9102791cd73b76e2820c
https://doi.org/10.1023/a:1015836720294
https://doi.org/10.1023/a:1015836720294
Publikováno v:
Pharmaceutical Research. :1032-1038
Two forms of chemically synthesized human relaxin (hRlx and hRlx-2) were administered as 88 µg/kg intravenous bolus doses to pregnant and nonpregnant rhesus monkeys. No significant differences in pharmacokinetics were observed between pregnant and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0081cc4f48f44ae49065896182844c3a
https://doi.org/10.1023/a:1015861108966
https://doi.org/10.1023/a:1015861108966
Autor:
Bobbe L. Ferraiolo, Robert J. Wills
Publikováno v:
Clinical pharmacokinetics. 23(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640f0862db11007ef0538c7e0bc71540
https://pubmed.ncbi.nlm.nih.gov/1458760
https://pubmed.ncbi.nlm.nih.gov/1458760
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781489923318
Protein Pharmacokinetics and Metabolism
Protein Pharmacokinetics and Metabolism
Goals and Analytical Methodologies for Protein Disposition Studies B.L. Ferraiolo, M.A. Mohler. Binding Proteins of Protein Therapeutics M.A. Mohler, et al. Potential Effects of Antibody Induction by Protein Drugs P.K. Working. Pharmacokinetics and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91081a2346f0c1702eaeded38db5c71
https://doi.org/10.1007/978-1-4899-2329-5
https://doi.org/10.1007/978-1-4899-2329-5
Autor:
Bobbe L. Ferraiolo, Leslie Z. Benet
Publikováno v:
Pharmaceutical Research; Jul1985, Vol. 2 Issue 4, p151-156, 6p
Autor:
Leslie Z. Benet, Bobbe L. Ferraiolo
Publikováno v:
Pharmaceutical Research. :151-156
Relatively small modifications of clinically useful endogenous compounds have been shown to have therapeutically beneficial effects on their pharmacodynamic and pharmacokinetic properties. These effects include increased potency and effect selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9409b7a1bb724e2b5e446ad3e7cb8cc2
https://doi.org/10.1023/a:1016327803573
https://doi.org/10.1023/a:1016327803573
Publikováno v:
Biochemistry. 23:5534-5539
In the accompanying paper [Ferraiolo, B. L., Onady, G. M., & Mieyal, J. J. (1984) Biochemistry (preceding paper in this issue)] we reported different aniline hydroxylase activities for ferrihemoglobin, its isolated subunits, and the converse pair of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5997705489ceeaf14830cc3b3c5c0dd4
https://doi.org/10.1021/bi00318a024
https://doi.org/10.1021/bi00318a024