Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bob Y. Liu"'
Autor:
Ying-Ping Jiang, Bob Y. Liu, Quan Zheng, Swapna Panuganti, Ruoying Chen, Jianyu Zhu, Madhavi Mishra, Jianqing Huang, Trang Dao-Pick, Sharmili Roy, XiaoXian Zhao, Jeffrey Lin, Gautam Banik, Eric D. Hsi, Ramkumar Mandalam, Jagath R. Junutula
Publikováno v:
Blood Advances, Vol 2, Iss 14, Pp 1738-1749 (2018)
Abstract: The current standard of care for acute myeloid leukemia (AML) is largely ineffective with very high relapse rates and low survival rates, mostly due to the inability to eliminate a rare population of leukemic stem cells (LSCs) that initiate
Externí odkaz:
https://doaj.org/article/d8b82c6365ea4c089351c6964cf8ee5e
Autor:
Bob Y Liu, Irina Soloviev, Peter Chang, John Lee, XiaoDong Huang, Cuiling Zhong, Napoleone Ferrara, Paul Polakis, Chie Sakanaka
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8611 (2010)
BACKGROUND: Histological examinations of MMTV-Wnt1 tumors reveal drastic differences in the tumor vasculature when compared to MMTV-Her2 tumors. However, these differences have not been formally described, nor have any angiogenic factors been implica
Externí odkaz:
https://doaj.org/article/66c5507710c64344a06eaa2e53605330
Autor:
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz:
https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
Autor:
Trang Dao-Pick, Sharmili Roy, Jianqing Huang, Xiaoxian Zhao, Jeffrey Lin, Bob Y. Liu, Madhavi Mishra, Swapna Panuganti, Eric D. Hsi, Quan Zheng, Gautam Banik, Ying-Ping Jiang, Jagath Reddy Junutula, Ruoying Chen, Ramkumar Mandalam, Jianyu Zhu
The current standard of care for acute myeloid leukemia (AML) is largely ineffective with very high relapse rates and low survival rates, mostly due to the inability to eliminate a rare population of leukemic stem cells (LSCs) that initiate tumor gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac57d695219ccb38fc849bd753243be6
https://europepmc.org/articles/PMC6058235/
https://europepmc.org/articles/PMC6058235/
Autor:
Joel Shen, Jennifer Richardson, Bob Y. Liu, Siew Schleyer, Annie Yang Weaver, Matthias Will, Sreeni Yalamanchili, Michael P. Kavanaugh, Marcia Belvin, Judi Gordon, Luc Desnoyer, Mark Stroh
Publikováno v:
Cancer Research. 79:212-212
Ideal targets for antibody drug conjugates (ADC) are highly and homogeneously expressed on tumor cells in a wide variety of tumor types and in a high proportion of patients. Such targets should also be efficient cellular internalizers and have limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f82c61f3382dd74a740c88046562950
https://doi.org/10.1158/1538-7445.am2019-212
https://doi.org/10.1158/1538-7445.am2019-212
Autor:
Kim Newton, Sarah G. Hymowitz, XiaoDong Huang, Anthony Wynshaw-Boris, Michael Kakunda, Christine Yu, Paul Polakis, Victoria Pham, Jo Anne Hongo, Jennie R. Lill, Bob Y. Liu, Rami N. Hannoush, Richard M. Harland, James C. McGann, Jinfeng Liu, Vishva M. Dixit
Publikováno v:
Science. 339:1441-1445
Receptor interacting protein kinase 4 (RIPK4) is required for epidermal differentiation (1–4) and is mutated in Bartsocas-Papas syndrome (5, 6). While RIPK4 binds protein kinase C (5, 6), RIPK4 signaling mechanisms are largely unknown. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be54393ccf5fd6e5ea2f1d849268b4c4
https://doi.org/10.1126/science.1232253
https://doi.org/10.1126/science.1232253
Autor:
Bob Y. Liu, Irina Soloviev, James A. Ernst, Paul Polakis, Chie Sakanaka, XiaoDong Huang, Peter Chang
Publikováno v:
Cancer Research. 72:1568-1578
Wnt ligand–driven tumor growth is inhibited by the soluble Wnt inhibitor Fzd8CRD, but the mechanism through which this effect is mediated is unknown. In the MMTV-Wnt1 mouse model, regression of mammary tumors by Fzd8CRD treatment coincides with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ca3cc2b583b84ba2e41554aae9d342
https://doi.org/10.1158/0008-5472.can-11-3668
https://doi.org/10.1158/0008-5472.can-11-3668
Publikováno v:
Proceedings of the National Academy of Sciences. 101:4158-4163
Ectopic activation of the Wnt signaling pathway is highly oncogenic for many human tissues. Here, we show that ectopic Wnt signaling increases the effective stem cell activity in mouse mammary glands in vivo . Furthermore, Wnt effectors induce the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3925515852980c4135d277bedc4d6b03
https://doi.org/10.1073/pnas.0400699101
https://doi.org/10.1073/pnas.0400699101
Autor:
Madhavi Mishra, Jeffrey Lin, Sharmili Roy, Eric D. Hsi, Ping Jiang, J. Huang, Xiaoxian Zhao, Jagath Reddy Junutula, Jennifer Lu, Bob Y. Liu
Publikováno v:
Cancer Research. 76:3337-3337
The current standard of care for Acute Myeloid Leukemia (AML) is largely ineffective in terms of achieving long term remission. This is mostly due to inability to remove all of the leukemic cells, and there is accumulating evidence to support the rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84c23596b54afd9c15e9a9fbaf0505db
https://doi.org/10.1158/1538-7445.am2016-3337
https://doi.org/10.1158/1538-7445.am2016-3337