Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bob Stork"'
Autor:
Peter C Verveer, Bob Stork, Hein K. A. C. Coolen, Alice J.M. Borst, Josephus H. M. Lange, Martina A.W. van der Neut, Chris G. Kruse
Publikováno v:
Journal of Medicinal Chemistry. 53:1338-1346
Pyrazolines 7-10 were designed as novel CB(1) receptor antagonists, which exhibited improved turbidimetric aqueous solubilities. On the basis of their extended CB(1) antagonist pharmacophore, hybrid molecules exhibiting cannabinoid CB(1) receptor ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a17a640414c9826697d448ffeea4e10
https://doi.org/10.1021/jm901614b
https://doi.org/10.1021/jm901614b
Autor:
Arnold P. den Hartog, Dijksman Jessica A R, Koos Tipker, Hiskias G. Keizer, Hein K. A. C. Coolen, Henri C. Wals, Tiny J.P. Adolfs, Bob Stork, Peter C Verveer, Andrew C. McCreary, Josephus H. M. Lange, Natasja M J de Jong, Herman H. van Stuivenberg, Jan Hoogendoorn, Chris G. Kruse, Arnoud H.J. Herremans, Eric Ronken, Willem Veerman
Publikováno v:
Journal of Medicinal Chemistry. 47:627-643
A series of novel 3,4-diarylpyrazolines was synthesized and evaluated in cannabinoid (hCB(1) and hCB(2)) receptor assays. The 3,4-diarylpyrazolines elicited potent in vitro CB(1) antagonistic activities and in general exhibited high CB(1) vs CB(2) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf7d3905b901be5418d4523216fb0d
https://doi.org/10.1021/jm031019q
https://doi.org/10.1021/jm031019q
Publikováno v:
Pesticide Science. 29:101-108
N-(2-pyrazolin-1-ylformyl) benzenesulfonamides form a new group of compounds with interesting herbicidal activity. Some of the chemical, biological and biochemical characteristics of this group are described. The herbicidal activity is mainly express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512eb57099864004e09f2b9f8f4cc204
https://doi.org/10.1002/ps.2780290113
https://doi.org/10.1002/ps.2780290113
Autor:
Henri C. Wals, Herman H. van Stuivenberg, Josephus H. M. Lange, Bob Stork, Andrew C. McCreary, Hein K. A. C. Coolen, Willem Veerman, Tiny J.P. Adolfs, Chris G. Kruse
Publikováno v:
ChemInform. 37
Novel 3,4-diarylpyrazolines 1 as potent CB1 receptor antagonists with lipophilicity lower than that of SLV319 are described. The key change is the replacement of the arylsulfonyl group in the original series by a dialkylaminosulfonyl moiety. The abso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1008e9f207f18e4e8bd539570cad349d
https://doi.org/10.1002/chin.200605111
https://doi.org/10.1002/chin.200605111
Autor:
Hiskias G. Keizer, Chris G. Kruse, and Arnoud H. J. Herremans, Janpeter de Moes, Herman H. van Stuivenberg, Hein K. A. C. Coolen, Arnold P. den Hartog, Martin Tulp, Rolf van Hes, Leonarda C. Niemann, Andrew C. McCreary, Rob H. Plekkenpol, Mayke B. Hesselink, Cees N. J. Stroomer, Bob Stork, Pieter Smid
Publikováno v:
Journal of medicinal chemistry. 48(22)
A series of novel bicyclic 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines was synthesized and evaluated on binding to dopamine D(2) receptors and serotonin reuptake sites. This class of compounds proved to be potent in vitro dopamine D(2) rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6dfd58fc02e458bbdfc217b38e9ce3
https://pubmed.ncbi.nlm.nih.gov/16250644
https://pubmed.ncbi.nlm.nih.gov/16250644