Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bob Lubamba"'
Publikováno v:
Applied Sciences, Vol 12, Iss 6, p 2786 (2022)
Microfluidic screening tools, in vitro, evolve amid varied scientific disciplines. One emergent technique, simultaneously assessing cell toxicity from a primary compound and ensuing cell-generated metabolites (dual-toxicity screening), entails in-lin
Externí odkaz:
https://doaj.org/article/255f9d6fb4bd4bb8b7b332f0d653568c
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 192:1449-1461
Alveolar macrophages (AMs) play a key role in host defense to inhaled bacterial pathogens, in part by secreting inflammatory mediators. Cystic fibrosis (CF) airways exhibit a persistent, robust inflammatory response that may contribute to the pathoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c599357758a5a3a90c095789b9b416f
https://doi.org/10.1164/rccm.201504-0657oc
https://doi.org/10.1164/rccm.201504-0657oc
Publikováno v:
Clinical Biochemistry. 45:1132-1144
Cystic fibrosis is the most common life-threatening recessively inherited disease in Caucasians. Due to early provision of care in specialized reference centers and more comprehensive care, survival has improved over time. Despite great advances in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755d317035e9d349c1c1e826eca60c9c
https://doi.org/10.1016/j.clinbiochem.2012.05.034
https://doi.org/10.1016/j.clinbiochem.2012.05.034
Autor:
Jean Lebacq, Pierre Wallemacq, François Huaux, Barbara Dhooghe, Teresinha Leal, Etienne Marbaix, Bob Lubamba, Nadtha Panin
Publikováno v:
Journal of Cystic Fibrosis
Journal of Cystic Fibrosis; Vol 11
Journal of Cystic Fibrosis; Vol 11
BACKGROUND: We tested the hypothesis that vardenafil, a common drug used for improving erectile dysfunction and able to partially normalize transepithelial chloride transport in cystic fibrosis (CF), modulates CF lung inflammation. METHODS: Inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39313215c325b8a16e95a20169505909
Autor:
Pierre Wallemacq, Patrick Lebecque, Barbara Dhooghe, Sabrina Noël, Anissa Leonard, Bob Lubamba, Teresinha Leal
Publikováno v:
Open Journal of Respiratory Diseases, Vol. 2, p. 43-56 (2012)
Background: Nasal potential difference (NPD) test has long been used to assist in the diagnosis of Cystic Fibrosis (CF) and more recently as an outcome measure in clinical trials of new CF therapies. This test has also been adapted to the mouse nose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad7401bf85d8943937e32341b639094
https://doi.org/10.4236/ojrd.2012.22007
https://doi.org/10.4236/ojrd.2012.22007
Autor:
Pierre Wallemacq, Teresinha Leal, Gregory Reychler, Etienne Marbaix, Bob Lubamba, Patrick Lebecque, Jean Lebacq
Publikováno v:
European Respiratory Journal. 37:72-78
Sildenafil and vardenafil, two selective inhibitors of phosphodiesterase type 5 (PDE5) are able, when applied by intraperitoneal injection, to activate chloride transport in cystic fibrosis (CF) mice homozygous for the F508del mutation. Oral treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc8b6d1c79ea1aee02b0ec370f1af91
https://doi.org/10.1183/09031936.00013510
https://doi.org/10.1183/09031936.00013510
Autor:
Bob Lubamba, Rita Vanbever, Anissa Leonard, Pierre Wallemacq, Teresinha Leal, Patrick Lebecque, Jean Lebacq
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 179:1022-1028
N-butyldeoxynojyrimicin (NB-DNJ, miglustat [Zavesca]) an approved drug for treating Gaucher disease, was reported to be able to correct the defective trafficking of the F508del-CFTR protein.To evaluate the efficacy of in vivo airway delivery of miglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee22b48cbd8b642dc31e5c96b2500bc6
https://doi.org/10.1164/rccm.200901-0049oc
https://doi.org/10.1164/rccm.200901-0049oc
Publikováno v:
Cystic Fibrosis-Renewed Hopes Through Research
Recent basic research has aroused great interest in the therapeutic potential of phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, vardenafil and taladafil, for the treatment of cystic fibrosis (CF). CF is the most common, life-threaten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1633e8c8b07a5d880cb5e7826ed7e273
http://www.intechopen.com/articles/show/title/pharmacological-potential-of-pde5-inhibitors-for-the-treatment-of-cystic-fibrosis
http://www.intechopen.com/articles/show/title/pharmacological-potential-of-pde5-inhibitors-for-the-treatment-of-cystic-fibrosis
Autor:
Pierre Wallemacq, François Huaux, Patrick Lebecque, Teresinha Leal, Nadtha Panin, Jean Lebacq, Bob Lubamba
Publikováno v:
Journal of Cystic Fibrosis. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de6f158aca01e109089a3adca35945c
Autor:
B. Dooghe, Patrick Lebecque, Teresinha Leal, Sabrina Noël, Pierre Wallemacq, Bob Lubamba, Anissa Leonard
Publikováno v:
Journal of Cystic Fibrosis. 11:S62
Comparative variability of nasal potential difference measurements in human and mice, healthy or carrying two severe CFTR mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdefb4615dc02f641c4f791c1756a97
https://doi.org/10.1016/s1569-1993(12)60196-9
https://doi.org/10.1016/s1569-1993(12)60196-9