Data from Rapid and Robust Transgenic High-Grade Glioma Mouse Models for Therapy Intervention Studies

Autor: Olaf van Tellingen, Anton J.M. Berns, Maarten van Lohuizen, Jos H. Beijnen, William P. Leenders, Bob C. Hamans, Tessa Buckle, John Zevenhoven, Hilda I. de Vries, Danielle Hulsman, Sophia W. Bruggeman, Nienke A. de Vries

Purpose: To develop a transgenic mouse model of glioma that can be conveniently used for testing therapy intervention strategies. High-grade glioma is a devastating and uniformly fatal disease for which better therapy is urgently needed. Typical for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9f297f119211cc06a19371ad15ae6d
https://doi.org/10.1158/1078-0432.c.6518664.v1

IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma

Autor: Arend Heerschap, Anna C. Navis, Bob C. Hamans, Morteza Esmaeili, Ingrid S. Gribbestad, Tone Frost Bathen, Remco van Horssen, William P.J. Leenders

Publikováno v: Cancer Research, 74, 17, pp. 4898-907
Cancer Research, 74, 4898-907

Contains fulltext : 135917.pdf (Publisher’s version ) (Closed access) Many patients with glioma harbor specific mutations in the isocitrate dehydrogenase gene IDH1 that associate with a relatively better prognosis. IDH1-mutated tumors produce the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9c1f92a64e69bbd058f7fa3cd2fda5
https://doi.org/10.1158/0008-5472.can-14-0008

Metabolic imaging of multiple X-nucleus resonances

Autor: Arend Heerschap, Bob C. Hamans, Isabell K. Steinseifer, Tom W. J. Scheenen, Jannie P. Wijnen

Publikováno v: Magnetic Resonance in Medicine. 70:169-175

This study describes a technique for fast imaging of x-nuclei metabolites. Due to increased sensitivity and larger chemical shift dispersion at high magnetic fields, images of multiple metabolites can be obtained simultaneously by selective excitatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccb0fa06c6ca0c8bef8ab810521f5290
https://doi.org/10.1002/mrm.24456

Tumor Models (In Vivo/In Vitro)

Autor: Gerald Steiner, Stefan Rutkowski, David M. Loeb, Jochen Herms, Samuel D. Rabkin, G.J. Kaspers, Ling-Yuan Kong, Reiner Salzer, Tokomo Ozawa, Anneke C. Navis, Rob C. Hoeben, John J. Lannutti, Nalin Gupta, ZhaoBin Zhang, Alfredo Quinones-Hinojosa, Dolores Hambardzumyan, Jon D. Weingart, Mariano S. Viapiano, Michał Nowicki, Gregory J. Riggins, Celina Crisman, Chen Gang, Elena I. Fomchenko, Martine L.M. Lamfers, Yuan Rong, Carol Tucker-Burden, I Zondervan, P. Wesseling, Deepak Kamnasaran, Enio A. Chiocca, Jose Bergeron, Julia Sisti, Sanne K. van den Hengel, Anat Stemmer-Rachamimov, Nikolaus Schultz, Gabriele Schackert, Jun Wei, Jonathan P. Yun, Bob C. Hamans, Fabien G. Lafaille, Shengguo Li, Amparo Wolf, Paula A. Agudelo, Jochem K H Spoor, Rolf Bjerkvig, Abhijit Guha, Sameer Agnihotri, Preeti Shah, Andreas Lorenz, Gregory N. Fuller, Xiaoyan Zhu, Nesrin Sabha, Michael Lim, Stephen Yip, Frits Thorsen, Viviane Tabar, Allison Stelling, Judith W. M. Jeuken, William T. Curry, Arend Heerschap, Nduka Amankulor, Hiroaki Wakimoto, Lakshmi Katuri, Yasuyuki Aoki, Hadie Adams, Jenneke Kloezeman, Raelene Endersby, P. van der Valk, T. Wurdinger, Wesley Hsu, André Von Bueren, Antonio Aliaga, Suzanne J. Baker, Matthias Kirsch, David W. Ellison, Sander Idema, Yuhui Yang, Norbert Ajewung, Massimo Squatrito, C. Molthoff, D. H. Meijer, Gayatry Mohapatra, Pim J. French, Rutger K. Balvers, An Claes, M. Bugiani, Hans A. Kretzschmar, Michael Castelli, Pui K. Li, Thomas Kosztowski, Ganesh Rao, Zev A. Binder, W. Vos, M. Barazas, Eric C. Holland, Amanda M. Katz, Anne Kleijn, Chunxu Qu, Jeffrey N. Bruce, P.M. van der Stoop, Robert L. Martuza, Sidney Croul, Ahmed Mohyeldin, Shante Williams, Jed Johnson, Heike Immervoll, Aurelia Peraud, W.P. Vandertop, Sherri Rankin, Erwin Van Meir, Anne Lenferink, Adam Studebaker, Amy B. Heimberger, Lorenz Studer, Clemens M F Dirven, E. Hulleman, Sieger Leenstra, Ziya L. Gokaskan, Peter Canoll, Sagar R. Shah, Henry Brem, Pieter Wesseling, Ulrike S. Trojahn, Gary L. Gallia, Ryuichi Kanai, Vafi Salmasi, Mengqing Xiang, Julia Pöschl, D.J. Brat, Stephen D. Nimer, Craig Soderquist, Lionel M. Chow, T. Lagerweij, Tiffany Doucette, Jean-Paul Wolinsky, Elena Bazzoli, Jörg-Christian Tonn, Christoph Krafft, Maureen O'Connor-McCourt, Ulrich Schüller, Andreas von Deimling, Inderjit Daphu, Rintaro Hashizume, Alessandro Olivi, Adam Sonabend, William P.J. Leenders, Lisa M. DeAngelis, Liang Lei, C.D. James, D. Noske, Cameron Brennan, Sean E. Lawler, Junyuan Zhang, B. Hamans, Corey Raffel, Jinbo Wang, Barry J. Bedell, V. Caretti, Zachary R. Barnard

Publikováno v: Neuro-Oncology. 12:iv130-iv136

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d849b4c95f927567cbc1ec9d594ee97a
https://doi.org/10.1093/neuonc/noq116.s20

In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts

Autor: Morteza, Esmaeili, Siver A, Moestue, Bob C, Hamans, Andor, Veltien, Alexandr, Kristian, Olav, Engebråten, Gunhild M, Maelandsmo, Ingrid S, Gribbestad, Tone F, Bathen, Arend, Heerschap

Publikováno v: Journal of magnetic resonance imaging : JMRI. 41(3)

To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor response to anticancer therapy. We explored 3D (31) P magnetic resonance spectroscopic imaging (MRSI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e6de2c0bb83bd977b8b2a7bf6c54a88
https://pubmed.ncbi.nlm.nih.gov/24532410