Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bob A Hersbach"'
Autor:
Bob A Hersbach, David S Fischer, Giacomo Masserdotti, Deeksha, Karolina Mojžišová, Thomas Waltzhöni, Diego Rodriguez‐Terrones, Matthias Heinig, Fabian J Theis, Magdalena Götz, Stefan H Stricker
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp n/a-n/a (2022)
Abstract Despite the therapeutic promise of direct reprogramming, basic principles concerning fate erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these fundamental questions, we established a single‐cell pro
Externí odkaz:
https://doaj.org/article/7ee96a824f2445ee879799d35c3bf713
Autor:
Karolina Pircs, Rebecca Petri, Sofia Madsen, Per Ludvik Brattås, Romina Vuono, Daniella R. Ottosson, Isabelle St-Amour, Bob A. Hersbach, Monika Matusiak-Brückner, Sofia Hult Lundh, Åsa Petersén, Nicole Déglon, Sébastien S. Hébert, Malin Parmar, Roger A. Barker, Johan Jakobsson
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1397-1406 (2018)
Summary: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In
Externí odkaz:
https://doaj.org/article/aa4ff126368d4f88950180d6f7fe4264
Autor:
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson
Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667921ae8a7da270bf48986c499fbc03
https://www.repository.cam.ac.uk/handle/1810/332257
https://www.repository.cam.ac.uk/handle/1810/332257
Publikováno v:
J. Vis. Exp. 2022:185 (2022)
Direct neuronal reprogramming is a powerful approach to generate functional neurons from different starter cell populations without passing through multipotent intermediates. This technique not only holds great promises in the field of disease modeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10b6f5d25ba5db3e9887b26bf0d41de
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65729
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=65729
Autor:
K.C Sharma, Horváth, Sébastien S. Hébert, Malin Parmar, György Marko-Varga, Lagerwall J, Bob A. Hersbach, Janelle Drouin-Ouellet, Roger A. Barker, Petter Storm, Patrik Johansson, Jeovanis Gil, Romina Vuono, Kenneth D. M. Harris, Melinda Rezeli, Daniela A. Grassi, Yogita Sharma, Karolina Pircs, Marie E. Jönsson, Isabelle St-Amour, Lagerström S, Johan Jakobsson, Thomas B Stoker, Raquel Garza
Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD has remained challenging, as rodent and cellular models poorly recapitulate the disease. To address this, we generated ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e319f860465633ac18adccdda66bad1
https://doi.org/10.1101/2021.03.01.433433
https://doi.org/10.1101/2021.03.01.433433
Autor:
Sofia Madsen, Per Ludvik Brattås, Bob A. Hersbach, Johan Jakobsson, Rebecca Petri, Karolina Pircs
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Activation of macroautophagy/autophagy, a key mechanism involved in the degradation and removal of aggregated proteins, can successfully reverse Huntington disease phenotypes in various model systems. How neuronal autophagy impairments need to be con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0181fc9f7b47e31deb56330b6144059b
Autor:
Bob A. Hersbach, Daniella Rylander Ottosson, Monika Matusiak-Brückner, Malin Parmar, Isabelle St-Amour, Per Ludvik Brattås, Romina Vuono, Sébastien S. Hébert, Sofia Madsen, Rebecca Petri, Johan Jakobsson, Nicole Déglon, Åsa Petersén, Roger A. Barker, Karolina Pircs, Sofia Hult Lundh
Publikováno v:
Cell reports, vol. 24, no. 6, pp. 1397-1406
Cell Reports, Vol 24, Iss 6, Pp 1397-1406 (2018)
Cell Reports, Vol 24, Iss 6, Pp 1397-1406 (2018)
Summary: Many neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences of impaired autophagy for neuronal function remain poorly understood. In