Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Bob, Wilffert"'
Autor:
Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, Chonlaphat Sukasem
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Recently, the Clinical Pharmacogenetics Implementation Consortium (CPIC) have revised recommendations for the translation of CYP2D6 genotype to phenotype. Changes affect phenotype grouping, as well as the value used to calculate activity sco
Externí odkaz:
https://doaj.org/article/ebf0c9230abb4e119004cb08ef98e00d
Autor:
Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Roger Gaedigk, Wiranpat Kittitharaphan, Nattawat Ngamsamut, Penkhae Limsila, Apichaya Puangpetch, Rattanaporn Sukprasong, Chonlaphat Sukasem
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We investigated the association between genetic variations in pharmacodynamic genes and risperidone-induced increased prolactin levels in children and adolescents with autism spectrum disorder (ASD). In a retrospective study, variants of pharmacodyna
Externí odkaz:
https://doaj.org/article/48831bc95a8741539a1023574ca0a377
Autor:
Diana Z. Osmanova, Maxim B. Freidin, Olga Yu. Fedorenko, Ivan V. Pozhidaev, Anastasiia S. Boiko, Natalia M. Vyalova, Vladimir V. Tiguntsev, Elena G. Kornetova, Anton J. M. Loonen, Arkadiy V. Semke, Bob Wilffert, Nikolay A. Bokhan, Svetlana A. Ivanova
Publikováno v:
BMC Medical Genetics, Vol 20, Iss S1, Pp 35-44 (2019)
Abstract Background Hyperprolactinemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 receptors (DRD2s) on the membranes of lactotroph cells within the pituitary gland. Certain antipsychotic d
Externí odkaz:
https://doaj.org/article/d99fb35098324075997db59f81e60a4e
Autor:
Yuanyuan Wang, Bob Wilffert, Eelko Hak, H. Marike Boezen, Jens H. Bos, Catharina C.M. Schuiling-Veninga, Job F. M. van Boven
Publikováno v:
BMJ Open, Vol 11, Iss 5 (2021)
Objectives To evaluate the real-world association between varenicline and neuropsychiatric adverse events (NPAEs) in general and chronic obstructive pulmonary disease (COPD) population with and without psychiatric disorders compared with nicotine rep
Externí odkaz:
https://doaj.org/article/57553943a1af4dbb89d98f1e9f1a8831
Publikováno v:
Hayati Journal of Biosciences, Vol 28, Iss 1 (2021)
One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and
Externí odkaz:
https://doaj.org/article/e78232756aa64b80926d1d7b56c4b18b
Autor:
Annika M. A. Berends, Mathieu S. Bolhuis, Ilja M. Nolte, Edward Buitenwerf, Thera P. Links, Henri J. L. M. Timmers, Richard A. Feelders, Elisabeth M. W. Eekhoff, Eleonora P. M. Corssmit, Peter H. Bisschop, Harm R. Haak, Ron H. N. van Schaik, Samira el Bouazzaoui, Bob Wilffert, Michiel N. Kerstens
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 896 (2022)
Background: Presurgical treatment with an α-adrenergic receptor blocker is recommended to antagonize the catecholamine-induced α-adrenergic receptor mediated vasoconstriction in patients with pheochromocytoma or sympathetic paraganglioma (PPGL). Th
Externí odkaz:
https://doaj.org/article/47388fe947114605b5393398298c233c
Autor:
H Marike Boezen, Yuanyuan Wang, Bob Wilffert, Eelko Hak, Jan-Willem C Alffenaar, Jens H Bos, J F M van Boven, Catharina C M Schuiling-Veninga
Publikováno v:
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
Introduction Although bacteria contribute significantly to acute exacerbations of chronic obstructive pulmonary disease (AECOPD), the added value of antibiotics remains controversial, especially in outpatient settings. Age may affect antibiotic effec
Externí odkaz:
https://doaj.org/article/a35a8b6c26a7485bbd9483d3b3b20aec
Autor:
Muh. Akbar Bahar, Jens H. J. Bos, Sander D. Borgsteede, Aafje Dotinga, Rolinde A. Alingh, Bob Wilffert, Eelko Hak
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundDrug-drug interaction (DDI) is one of the main contributors to adverse drug reactions and therefore, it is important to study its frequency in the population. We aimed to investigate frequency and concordance on CYP2D6, CYP2C19, and CYP2C9
Externí odkaz:
https://doaj.org/article/0fe60b47876e442bbf49c0c4a06d41cf
Autor:
Ivan V. Pozhidaev, Diana Z. Paderina, Olga Yu. Fedorenko, Elena G. Kornetova, Arkadiy V. Semke, Anton J. M. Loonen, Nikolay A. Bokhan, Bob Wilffert, Svetlana A. Ivanova
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
BackgroundTardive dyskinesia (TD) is a common side effect of antipsychotic treatment. This movement disorder consists of orofacial and limb-truncal components. The present study is aimed at investigating the role of serotonin receptors (HTR) in modul
Externí odkaz:
https://doaj.org/article/6d783e5a7d8245928975411558f6d60b
Autor:
Innokentiy S. Losenkov, Nathaniël J. V. Mulder, Lyudmila A. Levchuk, Natalya M. Vyalova, Anton J. M. Loonen, Fokko J. Bosker, German G. Simutkin, Anastasiia S. Boiko, Nikolay A. Bokhan, Bob Wilffert, Eelko Hak, Amand F. Schmidt, Svetlana A. Ivanova
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
BackgroundBrain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity, and its dysregulation has been associated with the pathogenesis of mood and anxiety disorders. Prolactin (PRL) is a pituitary hormone which is also pro
Externí odkaz:
https://doaj.org/article/12bd7c801fc74270853cf22658273b68