Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Boaz Wong"'
Autor:
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen
Externí odkaz:
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionAberrant expression of anaplastic lymphoma kinase (ALK) is found in 3%–7% of patients with non-small cell lung cancer (NSCLC). Alectinib is a tyrosine kinase inhibitor used as first-line treatment targeting ALK-positive tumors. We herei
Externí odkaz:
https://doaj.org/article/f74fb02c4174474a9188d6bc20b0689c
Autor:
Akram Alwithenani, Rozanne Arulanandam, Boaz Wong, Marcus M. Spinelli, Andrew Chen, Glib Maznyi, Victoria H. Gilchrist, Tommy Alain, Jean-Simon Diallo
Publikováno v:
Viruses, Vol 16, Iss 6, p 920 (2024)
Oncolytic virotherapy, using viruses such as vesicular stomatitis virus (VSVΔ51) and Herpes Simplex Virus-1 (HSV-1) to selectively attack cancer cells, faces challenges such as cellular resistance mediated by the interferon (IFN) response. Dimethyl
Externí odkaz:
https://doaj.org/article/e68341392f4b4cbdac032deca9f1be17
Autor:
Akram Alwithenani, Zaid Taha, Max Thomson, Andrew Chen, Boaz Wong, Rozanne Arulanandam, Jean-Simon Diallo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immunotherapy and specifically oncolytic virotherapy has emerged as a promising option for cancer patients, with oncolytic herpes simplex virus-1 (oHSV-1) expressing granulocyte macrophage colony stimulating factor being the first OV to be approved b
Externí odkaz:
https://doaj.org/article/9681e9f44e5e4063a33fb68404dc3744
Autor:
Donald J. Bastin, Joshua Montroy, Michael A. Kennedy, Andre B. Martel, Risa Shorr, Maryam Ghiasi, Dominique M. Boucher, Boaz Wong, Louise Gresham, Jean-Simon Diallo, Dean A. Fergusson, Manoj M. Lalu, Natasha Kekre, Rebecca C. Auer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We conducted a systematic review and meta-analysis of randomized control trials to formally assess the safety and efficacy of autologous whole cell vaccines as immunotherapies for solid tumors. Our primary safety outcome was number, and grad
Externí odkaz:
https://doaj.org/article/ddd371329bd54c08b78dd40a6df911c2
Autor:
Boaz Wong, Anabel Bergeron, Nouf Alluqmani, Glib Maznyi, Andrew Chen, Rozanne Arulanandam, Jean-Simon Diallo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 146-159 (2022)
Oncolytic virotherapy is a clinically validated approach to treat cancers such as melanoma; however, tumor resistance to virus makes its efficacy variable. Compounds such as sodium orthovanadate (vanadate) can overcome viral resistance and synergize
Externí odkaz:
https://doaj.org/article/b7838df85c4c411d8344541b202410f0
Publikováno v:
Case Reports in Oncology, Vol 15, Iss 1, Pp 285-290 (2022)
Epidermal growth factor receptor (EGFR) mutations are usually oncogenic drivers of lung tumor development and progression. While common sensitizing mutations respond well to targeted therapy, the relevance of germline EGFR mutations is less clear. We
Externí odkaz:
https://doaj.org/article/371e7b3635394612a6efcee05e316058
Autor:
Pardis Pakshir, Moien Alizadehgiashi, Boaz Wong, Nuno Miranda Coelho, Xingyu Chen, Ze Gong, Vivek B. Shenoy, Christopher A. McCulloch, Boris Hinz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Macrophages play an important role in wound healing but the guidance cues driving macrophages to sites of repair are still not clear. Here the authors discover that macrophages are attracted to contracting fibroblasts by responding to locally sensed
Externí odkaz:
https://doaj.org/article/84d14772127947a79875197d524838dc
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundCancer of unknown primary (CUP) describes patients with metastatic disease without an identified primary tumor site. Successful diagnosis and treatment of these patients remains difficult. Published guidelines on CUP have highlighted “fav
Externí odkaz:
https://doaj.org/article/0762c72e2cb344f696d369ff8ca64abe
Autor:
Kelly M Gutpell, Nikola Tasevski, Boaz Wong, William Thomas Hrinivich, Feng Su, Jennifer Hadway, Lise Desjardins, Ting-Yim Lee, Lisa Marie Hoffman
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174315 (2017)
Vascular endothelial growth factor (VEGF) and other pro-angiogenic growth factors have been investigated to enhance muscle tissue perfusion and repair in Duchenne muscular dystrophy (DMD). Current understanding is limited by a lack of functional data
Externí odkaz:
https://doaj.org/article/eebd0d1ab8154d2382c2d1de9e810a35