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of 7
pro vyhledávání: '"Boaz Kigel"'
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42912 (2012)
Class-3 semaphorins are secreted axon guidance factors. Some of these semaphorins have recently been characterized as suppressors of tumor progression. To determine if class-3 semaphorins can be used to inhibit the development of glioblastoma-multifo
Externí odkaz:
https://doaj.org/article/8771eb4ee39342b68c613d3b01644f54
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3287 (2008)
The class-3 semaphorins (sema3s) include seven family members. Six of them bind to neuropilin-1 (np1) or neuropilin-2 (np2) receptors or to both, while the seventh, sema3E, binds to the plexin-D1 receptor. Sema3B and sema3F were previously characteri
Externí odkaz:
https://doaj.org/article/bd875c5e30464da1816f64584e0432ea
Autor:
Massimiliano Mazzone, Federica Maione, Boaz Kigel, Andrea Casazza, Lorena Capparuccia, Luca Tamagnone, Gera Neufeld, Enrico Giraudo, Ofra Kessler
Publikováno v:
EMBO Molecular Medicine
Secreted Semaphorin 3E (Sema3E) promotes cancer cell invasiveness and metastatic spreading. The pro-metastatic activity of Sema3E is due to its proteolytic fragment p61, capable of transactivating the oncogenic tyrosine kinase ErbB2 that associates w
Publikováno v:
Blood. 118(15)
Plexin-A4 is a receptor for sema6A and sema6B and associates with neuropilins to transduce signals of class-3 semaphorins. We observed that plexin-A1 and plexin-A4 are required simultaneously for transduction of inhibitory sema3A signals and that the
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42912 (2012)
PLoS ONE, Vol 7, Iss 8, p e42912 (2012)
Class-3 semaphorins are secreted axon guidance factors. Some of these semaphorins have recently been characterized as suppressors of tumor progression. To determine if class-3 semaphorins can be used to inhibit the development of glioblastoma-multifo
Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases
Autor:
Shelly Zaffryar, Ofra Kessler, Gal Akiri, Sivan Abramovitch, Boaz Kigel, Asya Varshavsky, Gera Neufeld
Publikováno v:
Cancer research. 68(17)
Semaphorin-3B (sema3B) and semaphorin-3F (sema3F) are secreted tumor suppressors of lung cancer. Sema3F functions as an antiangiogenic factor that repels endothelial cells and compromises their proliferation/survival. However, tumor cells expressing
Publikováno v:
Cancer Research. 71:3268-3268
The Semaphorins and their receptors, Neuropilins and Plexins, were originally implicated as guidance signals in the development of the central nervous system. However, a growing body of evidence indicates that semaphorins may regulate tumor progressi