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PREDICT modeling and in-silico screening for G-protein coupled receptors

Autor: Yael Marantz, Alexander Heifetz, Dora Warshaviak, Silvia Noiman, Boaz Inbal, Maya Topf, Merav Fichman, Oren M. Becker, Zvi Naor, Noa Avisar, Sharon Shacham, Ori Kalid, Shay Bar-Haim

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 57:51-86

G-protein coupled receptors (GPCRs) are a major group of drug targets for which only one x-ray structure is known (the nondrugable rhodopsin), limiting the application of structure-based drug discovery to GPCRs. In this paper we present the details o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f73d8d55d83853d9da9bf9ea2b2dc1
https://doi.org/10.1002/prot.20195

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DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death

Autor: Shani Bialik, Ilana Sabanay, Boaz Inbal, Adi Kimchi, Gidi Shani

Publikováno v: The Journal of Cell Biology

Death-associated protein kinase (DAPk) and DAPk-related protein kinase (DRP)-1 proteins are Ca+2/calmodulin–regulated Ser/Thr death kinases whose precise roles in programmed cell death are still mostly unknown. In this study, we dissected the subce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450840070676b80d2c388712e7b40629
https://doi.org/10.1083/jcb.200109094

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Dap-Kinase Participates in TNF-α–And FAS-Induced Apoptosis and Its Function Requires the Death Domain

Autor: Joseph L. Kissil, Ofer Cohen, Tal Raveh, Taly Spivak-Kroizaman, Elena Feinstein, Adi Kimchi, Hanna Berissi, Boaz Inbal

Publikováno v: The Journal of Cell Biology

Death-associated protein (DAP)–kinase is a calcium/calmodulin regulated serine/threonine kinase that carries ankyrin repeats, a death domain, and is localized to the cytoskeleton. Here, we report that this kinase is involved in tumor necrosis facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbeaceaa080d015f575f503ee13d09b
https://doi.org/10.1083/jcb.146.1.141

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DAP kinase links the control of apoptosis to metastasis

Autor: Sylvie Polak-Charcon, Boaz Inbal, Adi Kimchi, Juri Kopolovic, Ofer Cohen, Ezra Vadai, Lea Eisenbach

Publikováno v: Nature. 390:180-184

DAP kinase is a new type of calcium/calmodulin-dependent enzyme that phosphorylates serine/threonine residues on proteins. Its structure contains ankyrin repeats and the 'death' domain, and it is associated with the cell cytoskeleton. The gene encodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2671505307bbdcfd2a3bb678d742ce16
https://doi.org/10.1038/36599

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Tailor Made LasR Agonists Modulate Quorum Sensing in Pseudomonas aeruginosa

Autor: Boaz Inbal, Michael M. Meijler, Pnina Krief, Antonia Delago, Nira Rabin

Publikováno v: Organic & Biomolecular Chemistry

The primary quorum sensing system in the opportunistic pathogen Pseudomonas aeruginosa is regulated through the synthesis and secretion of N-3-oxo-dodecanoyl-L-homoserine lactone (C12) which binds the transcriptional activator LasR. In this study we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9447023067e7c3c240b7e98583a3c996

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G protein-coupled receptors: In silico drug discovery in 3D

Autor: Merav Fichman, Oren M. Becker, Sharon Shacham, Dora Warshaviak, Shay Bar-Haim, Silvia Noiman, Boaz Inbal, Ori Kalid, Alexander Heifetz, Yael Marantz

The application of structure-based in silico methods to drug discovery is still considered a major challenge, especially when the x-ray structure of the target protein is unknown. Such is the case with human G protein-coupled receptors (GPCRs), one o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507cf343de0fe9320a4ed5905da87dd
https://europepmc.org/articles/PMC509175/

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Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis

Autor: Adi Kimchi, Joseph L. Kissil, Gidi Shani, Boaz Inbal, Ofer Cohen

Publikováno v: Molecular and cellular biology. 20(3)

In this study we describe the identification and structure-function analysis of a novel death-associated protein (DAP) kinase-related protein, DRP-1. DRP-1 is a 42-kDa Ca(2+)/calmodulin (CaM)-regulated serine threonine kinase which shows high degree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392f780e6d5a5165d2d0033fab961fc6
https://pubmed.ncbi.nlm.nih.gov/10629061

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Akademický článek

Breaking the Cycle of Chronicity in the Almog Young Adult Psychiatric Unit for the Development of Life Skills and Vocational Rehabilitation.

Autor: Naor, Ravit, Boaz, Inbal

Publikováno v: Israel Journal of Occupational Therapy / Ketab ’et Yiśreʼeliy Leriypẇy be ’Iysẇq; Nov2013, Vol. 22 Issue 4, pE104-E105, 2p

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