Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Bo Skaaning Jensen"'
Autor:
Jon Bondebjerg, Kirsten Rosendal Valeur, John Pedersen, Conni Lauritzen, Johnny Arnsdorf Hansen, René Orup Pedersen, Henrik Fuglsang, Lars Naerum, Bo Skaaning Jensen, Gitte Petersen, Berit Olsen Krogh, Dorte Wissing Kaznelson
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4408-4424
Human dipeptidyl peptidase I (hDPPI, cathepsin C, EC 3.4.14.1) is a novel putative drug target for the treatment of inflammatory diseases. Using 1 as a starting point (IC50 > 10 μM), we have improved potency by more than 500-fold and successfully id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f0a4286c8cff584035ee00f7a4f8e9
https://doi.org/10.1016/j.bmc.2005.04.048
https://doi.org/10.1016/j.bmc.2005.04.048
Autor:
Dorte Strøbæk, Søren-Peter Olesen, Katrine Kjær, Rie Schultz Hansen, Palle Christophersen, Lene Teuber, Tino Dyhring Jorgensen, Philip K. Ahring, Bo Skaaning-Jensen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1665:1-5
We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+-activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ee2d9995ecd1558a83998da7ca3cc3
https://doi.org/10.1016/j.bbamem.2004.07.006
https://doi.org/10.1016/j.bbamem.2004.07.006
Autor:
Morten Grunnet, Kamilla Angelo, Bo Skaaning Jensen, Dan A. Klaerke, Søren-Peter Olesen, Christian Frøkjær-Jensen, Thomas Jespersen
Publikováno v:
Neuropharmacology. 40:879-887
Small-conductance, calcium-activated K+ channels (SK channels) are voltage-insensitive channels that have been identified molecularly within the last few years. As SK channels play a fundamental role in most excitable cells and participate in afterhy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2f735961477a8a007b77de58fe8433
https://doi.org/10.1016/s0028-3908(01)00028-4
https://doi.org/10.1016/s0028-3908(01)00028-4
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 441:544-550
The purpose of the present study was to examine how apamin interacts with the three cloned subtypes of small-conductance Ca2+-activated K+ channels (hSK1, rSK2 and rSK3). Expression of the SK channel subtypes in Xenopus laevis oocytes resulted in lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4172893befa494da0b54c42bed8cd863
https://doi.org/10.1007/s004240000447
https://doi.org/10.1007/s004240000447
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 440:153-156
The effect of changes in pH on the gating properties of the cloned human intermediate-conductance, Ca2+-activated K+ channel (hIK) was studied using the patch-clamp technique. Multi-channel inside-out recordings of patches from HEK-293 cells stably e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70a6ec7021fbc8251d2d5556184b18
https://doi.org/10.1007/s004240000269
https://doi.org/10.1007/s004240000269
Autor:
Rikke Louise Schrøder, Palle Christophersen, Søren-Peter Olesen, Kamilla Angelo Pedersen, Bo Skaaning-Jensen, Dorte Strøbæk
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1420(1-2):231-240
Modulation of the cloned human intermediate-conductance Ca(2+)-activated K(+) channel (hIK) by the compound 1-ethyl-2-benzimidazolinone (EBIO) was studied by patch-clamp technique using human embryonic kidney cells (HEK 293) stably expressing the hIK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ac92c10bb0327cb13356d1499201ad
Publikováno v:
Annals of the New York Academy of Sciences. 841:97-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2885b8b81f73a447a04a1f24a09d54f
https://doi.org/10.1111/j.1749-6632.1998.tb10913.x
https://doi.org/10.1111/j.1749-6632.1998.tb10913.x
Publikováno v:
FEBS Letters. 426:212-216
The mongoose AChR alpha-subunit has been cloned and shown to be highly homologous to other AChR alpha-subunits, with only six differences in amino acid residues at positions that are conserved in animal species that bind alpha-bungarotoxin (alpha-BTX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dcb3ab6f71b9ff21ffdec23f680da7
https://doi.org/10.1016/s0014-5793(98)00341-x
https://doi.org/10.1016/s0014-5793(98)00341-x
Publikováno v:
FEBS Letters. 420:191-195
The different murine D2-type dopamine receptors (D2L, D2S, D3L, D3S, and D4) were expressed in Xenopus laevis oocytes. The D2-type receptors were all similarly and efficiently expressed in Xenopus oocytes and were shown to bind the D2 antagonist [125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ee774d5df7730db14015c728a73aef
https://doi.org/10.1016/s0014-5793(97)01505-6
https://doi.org/10.1016/s0014-5793(97)01505-6
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1284(1):97-108
Proteins of n-octyl glycoside solubilized membrane vesccles derived from Ehrlich ascites tumor cells can occlude 86 Rb + . K + displaces 86 Rb + and it is assumed that 86 Rb + can be used as a tracer to measure K + occlusion. The following observatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2933fdcea41d74ac3595b88efb879383