Breast cancer hormone receptor levels and benefit from adjuvant tamoxifen in a randomized trial with long-term follow-up

Autor: Helena Fohlin, Anna Nordenskjöld, Johan Rosell, Mårten Fernö, Tommy Fornander, Lisa Rydén, Lambert Skoog, Bo Nordenskjöld, Olle Stål

Publikováno v: Acta Oncologica, Vol 63, Iss 1 (2024)

Background: Hormone receptor positivity predicts benefit from endocrine therapy but the knowledge about the long-term survival of patients with different tumor receptor levels is limited. In this study, we describe the 25 years outcome of tamoxifen (

Externí odkaz: https://doaj.org/article/70fb0a9414d446158f65dbae4436b48e

Breast cancer survival and incidence of second primary cancers after 30 years in a randomized study of two versus five years of adjuvant tamoxifen therapy

Autor: Anna Nordenskjöld, Helena Fohlin, Johan Rosell, Nils-Olof Bengtsson, Tommy Fornander, Thomas Hatschek, Henrik Lindman, Per Malmström, Lisa Rydén, Arne Wallgren, Olle Stål, Bo Nordenskjöld

Publikováno v: Breast, Vol 71, Iss , Pp 63-68 (2023)

Background: Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated. Material and methods: We studied 30 years outcome of 4124 postmenopausal patients who were ra

Externí odkaz: https://doaj.org/article/487528a90ae34cc4bee6e74d37bc5e34

Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites

Autor: Lena Börjesson, Håkan Bladh, Didier Rognan, Chris de Graaf, Tero Linnanen, Annea Lisius, Hazel Joan Dyke, Malena Bengtsson, Marco van den Heuvel, Igor L. Shamovsky, Bo-Göran Josefsson, Bo Nordén, Anna Kristoffersson, Marco Skrinjar, Henrik Johansson, Lena Ripa, Stephen Connolly, Roope Männikkö, Klaus Urbahns, Lisa Alderin, Alexander Rosendahl, Steve Price

Publikováno v: Shamovsky, I, de Graaf, C, Alderin, L, Bengtsson, M, Bladh, H, Borjesson, L, Connolly, S, Dyke, H J, van den Heuvel, M, Johansson, H, Josefsson, B G, Kristoffersson, A, Linnanen, T, Lisius, A, Mannikko, R, Norden, B, Price, S, Ripa, L, Rognan, D, Rosendahl, A, Skrinjar, M & Urbahns, K 2009, ' Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites ', Journal of Medicinal Chemistry, vol. 52, no. 23, pp. 7706-23 . https://doi.org/10.1021/jm900713y
Journal of Medicinal Chemistry, 52(23), 7706-23. American Chemical Society

The metabolic stability and selectivity of a series of CCR8 antagonists against binding to the hERGion channel and cytochrome Cyp2D6 are studied by principal component analysis. It is demonstrated that an efficient way of increasing metabolic stabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcca9360c1fc85aab1528c4c95b4754
https://doi.org/10.1021/jm900713y

Drug Absorption from the Isolated Perfused Rat Lung–Correlations with Drug Physicochemical Properties and Epithelial Permeability

Autor: Per Brunmark, Bo Nordén, Hans Lennernäs, Ann-Britt Jeppsson, Elisabeth Nilsson, Ursula Hultkvist Bengtsson, Ann Tronde

Publikováno v: Journal of Drug Targeting. 11:61-74

The pulmonary absorption of nine low-molecular-weight (225-430 Da) drugs (atenolol, budesonide, enalaprilat, enalapril, formoterol, losartan, metoprolol, propranolol and terbutaline) and one high-molecular-weight membrane permeability marker compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e9dd66a510d2856fc713fce0b47a67
https://doi.org/10.1080/1061186031000086117

Solid phase synthesis of diamides as potential bone resorption inhibitors

Autor: Nina Kann, David J. Keeling, Bo Nordén, Vladimir Shcherbukhin, Jan P. Mattsson, Karin M Edvinsson, Patrik Holm, Margareta Herslöf

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:503-507

Unsymmetrical diamide libraries have been prepared by a general and versatile solid phase route, using diacid templates in combination with aromatic and aliphatic amines chosen with the help of statistical experimental design. The compounds were test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995422a539c93a2fd10a8de84def49ad
https://doi.org/10.1016/s0960-894x(00)00025-1