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pro vyhledávání: '"Bo Lundberg"'
Autor:
Bo Lundberg
Publikováno v:
International Journal of Pharmaceutics. 408:208-212
Paclitaxel is an effective and widely used anti-cancer agent. However, the drug is difficult to formulate for parenteral administration because of its low water solubility and Cremophor EL, the expient used for its formulation, has been shown to caus
Publikováno v:
Drug Delivery. 14:171-175
The purpose of our research was to evaluate in vitro therapeutic efficacy of doxorubicin (DXR)-loaded immunoliposomes with Fab' fragments of the anti-CD74 antibody LL1 attached to the surface. LL1 is well suited for targeting purposes because it is i
Autor:
Bolle Ravindra Babu, Lars Bo Lundberg, Stephen Douthwaite, Jesper Wengel, Sørensen, Birte Vester
Publikováno v:
Vester, B, Lundberg, L B, Sørensen, M D, Babu, B R, Douthwaite, S R & Wengel, J 2004, ' Improved RNA cleavage by LNAzyme derivatives of DNAzymes. ', Biochemical Society Transactions, vol. 32, no. 1, pp. 37-40 . https://doi.org/10.1042/bst0320037
Specific cleavage of RNA is catalysed by short oligodeoxynucleotides termed DNAzymes. DNAzymes consist of two binding arms that hybridize to a predetermined RNA sequence and a catalytic core that cleaves a phosphodiester bond held between the binding
Publikováno v:
Journal of Controlled Release. 94:155-161
The ability to selectively target anti-cancer drugs via specific ligands against antigens expressed on malignant cells could greatly improve the therapeutic indices of the drugs. In this paper an anti-CD74 antibody (Ab), LL1, was covalently attached
Autor:
Adriana Flachier, Stuart N. Lane, Göran Fredriksson, N. Håkan Tarras-Wahlberg, Bo Lundberg, Olof Sangfors
Publikováno v:
AMBIO: A Journal of the Human Environment. 29:484-491
Small-scale gold mining in southern Ecuador is causing considerable environmental impacts, the most important of which are related to the discharge of metals, metalloids and cyanide into adjacent rivers. In the rivers, these contaminants are generall
Publikováno v:
International Journal of Pharmaceutics. 134:119-127
Submicron-sized lipid emulsions possess many favourable properties as drug-carriers like biocompatibility, physical stability and ease of preparation. The use of colloidal carriers is, however, hampered by their rapid clearance from the circulation.
Autor:
Bo Lundberg
Publikováno v:
International Journal of Pharmaceutics. 109:73-81
Sub-micron sized lipid emulsions with lipophilic drugs entrapped in the oil core are a novel drug carrier system with many potential applications. In this study, lipophilic derivatives of the anticancer drugs etoposide and teniposide, with an unsatur
Autor:
Bo Lundberg
Publikováno v:
Journal of Pharmaceutical Sciences. 83:72-75
A method has been developed to produce lipid emulsion particles for parenteral use as drug carriers. The technique uses a mixture of a triacylglycerol oil and purified egg yolk phosphatidylcholine (EPC) as the basic system and sonication under mild c
Autor:
Bo Lundberg
Publikováno v:
International Journal of Pharmaceutics. 99:275-283
Many cancer cells express a higher receptor-mediated uptake of low-density lipoprotein (LDL) than normal cells. LDL has been proposed as a carrier for anticancer agents in order to improve the selectivity of cancer chemotherapeutics. In this study tw
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1149:305-312
Mixed phospholipid/cholesterol (2:1 molar ratio) liposomes were conjugated with native and acetylated apolipoprotein B (apoB), the protein part of low density lipoprotein (LDL). The objective was to increase the specificity of the cellular uptake of