Different associations between body mass index and Alzheimer’s markers depending on metabolic health

Autor: Eun Hye Lee, Heejin Yoo, Young Ju Kim, Bo Kyoung Cheon, Seungho Ryu, Yoosoo Chang, Jihwan Yun, Hyemin Jang, Jun Pyo Kim, Hee Jin Kim, Seong-Beom Koh, Jee Hyang Jeong, Duk L. Na, Sang Won Seo, Sung Hoon Kang

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)

Abstract Background Increasing evidence supports the association between body mass index (BMI), Alzheimer’s disease, and vascular markers. Recently, metabolically unhealthy conditions have been reported to affect the expression of these markers. We

Externí odkaz: https://doaj.org/article/0f8f3d408a744d3e9d9d262fa79fb183

Sex-specific relationship between non-alcoholic fatty liver disease and amyloid-β in cognitively unimpaired individuals

Autor: Sung Hoon Kang, Heejin Yoo, Bo Kyoung Cheon, Jun Pyo Kim, Hyemin Jang, Hee Jin Kim, Mira Kang, Kyungmi Oh, Seong-Beom Koh, Duk L. Na, Yoosoo Chang, Sang Won Seo

Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)

BackgroundNon-alcoholic fatty liver disease (NAFLD) is known to be associated with a high risk of clinically diagnosed Alzheimer’s disease (AD). Additionally, the prevalence of NAFLD and AD is higher in elderly females than in males. However, a sex

Externí odkaz: https://doaj.org/article/346c189ae8e34640bb498373721a1931

Distinct Brain Regions in Physiological and Pathological Brain Aging

Autor: Jin San Lee, Yu Hyun Park, Seongbeom Park, Uicheul Yoon, Yeongsim Choe, Bo Kyoung Cheon, Alice Hahn, Soo Hyun Cho, Seung Joo Kim, Jun Pyo Kim, Young Hee Jung, Key-Chung Park, Hee Jin Kim, Hyemin Jang, Duk L. Na, Sang Won Seo

Publikováno v: Frontiers in Aging Neuroscience, Vol 11 (2019)

BackgroundStudying structural brain aging is important to understand age-related pathologies, as well as to identify the early manifestations of the Alzheimer’s disease (AD) continuum. In this study, we investigated the long-term trajectory of phys

Externí odkaz: https://doaj.org/article/bd6be7ea69d847428aa35389993dd26a

The Cortical Neuroanatomy Related to Specific Neuropsychological Deficits in Alzheimer's Continuum

Autor: Young Hee Jung, Sung Hoon Kang, Yisuh Ahn, Hyemin Jang, Daun Lee, Hee Jin Kim, Jaeho Kim, Jongmin Lee, Hyejoo Lee, Jun Pyo Kim, Bo Kyoung Cheon, Duk L. Na, Ju Hee Chin, Sang Won Seo, Alice Hahn, Young Ju Kim, Seong Beom Park, Ji Sun Kim, Yu Hyun Park

Publikováno v: Dementia and Neurocognitive Disorders

Background and purpose In Alzheimer's continuum (a comprehensive of preclinical Alzheimer's disease [AD], mild cognitive impairment [MCI] due to AD, and AD dementia), cognitive dysfunctions are often related to cortical atrophy in specific brain regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b488f7f91afc3d5a3e422c0d8deace
http://europepmc.org/articles/PMC6819670

Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment

Autor: Michael W. Weiner, Hyejoo Lee, Hyemin Jang, Sang Won Seo, Seungjoo Kim, Young Hee Jung, Alice Hahn, Seonwoo Kim, Yeongsim Choe, Charles DeCarli, Jun Pyo Kim, Bo Kyoung Cheon, Key Chung Park, Soo Hyun Cho, Hee Jin Kim, Rik Ossenkoppele, Jin San Lee, Seongbeom Park, Heejin Yoo, Duk L. Na, Yu Hyun Park

Publikováno v: Lee, J S, Lee, H, Park, S, Choe, Y, Park, Y H, Cheon, B K, Hahn, A, Ossenkoppele, R, Kim, H J, Kim, S, Yoo, H, Jang, H, Cho, S H, Kim, S J, Kim, J P, Jung, Y H, Park, K C, DeCarli, C, Weiner, M W, Na, D L & Seo, S W 2020, ' Association between APOE ε2 and Aβ burden in patients with Alzheimer-and vascular-type cognitive impairment ', Neurology, vol. 95, no. 17, pp. e2354-e2365 . https://doi.org/10.1212/WNL.0000000000010811
Neurology, 95(17), e2354-e2365. Lippincott Williams and Wilkins
Neurology, vol 95, iss 17

ObjectiveTo investigate the association between APOE genotype and β-amyloid (Aβ) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease–related cognitive impairment (ADCI).Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461a3b5dfeecb7a63d52d406dcb6dfce
https://research.vumc.nl/en/publications/7fd20f31-bf81-4b13-9fa2-a3d2903d34cd