Zobrazeno 1 - 10
of 470
pro vyhledávání: '"Bo K. Siesjö"'
Autor:
Hiroyuki Uchino, Reiko Minamikawa-Tachino, Tibor Kristián, Guy Perkins, Michiko Narazaki, Bo K. Siesjö, Futoshi Shibasaki
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 3, Pp 219-233 (2002)
Transient global or forebrain ischemia leads to severe brain damage following delayed neuronal cell death. We previously reported that cyclosporin A (CsA) provides near total suppression of brain damage in rat forebrain ischemia when allowed to pass
Externí odkaz:
https://doaj.org/article/cea9138ac5ac4083aa3bbf6573f347be
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 1, Pp 147-154 (2001)
The serine-threonine kinase Akt1 promotes cell survival through inhibition of apoptosis. One of the potential downstream targets of Akt1 is p70 S6 kinase, p70S6K, an enzyme implicated in the regulation of protein synthesis. In this study, we investig
Externí odkaz:
https://doaj.org/article/2e8e508a57b4415fa002f7d575e1b248
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 1, Pp 127-135 (2001)
The present study was undertaken to investigate whether extracellular signal-regulated kinase (ERK) was involved in mediating hyperglycemia-exaggerated cerebral ischemic damage. Phosphorylation of ERK 1/2 was studied by immunocytochemistry and by Wes
Externí odkaz:
https://doaj.org/article/553ca284a394488d98e8eca6bca313e1
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 2, Pp 117-128 (1998)
Hyperglycemia is known to aggravate ischemic brain damage. The present experiments were undertaken to explore whether hyperglycemia caused by streptozotocin-induced diabetes exacerbates brain damage following transient brain ischemia as it does in an
Externí odkaz:
https://doaj.org/article/098e78a3f7c345c6ac77d913951524dc
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 3, Pp 288-300 (1997)
Recirculation following 2 h of focal ischemia due to transient middle cerebral artery (MCA) occlusion has previously been found to be accompanied by an initial, partial recovery of the cellular bioenergetic state and of mitochondrial respiratory func
Externí odkaz:
https://doaj.org/article/d7d16fc6e9ac4bc88b43efc40426342e
Publikováno v:
Neurobiology of Disease, Vol 3, Iss 2, Pp 149-157 (1996)
The present experiments were undertaken to explore the mechanisms of secondary brain damage in focal ischemia of long duration (2 h), followed by recirculation. Recirculation has previously been found to cause partial recovery and secondary deteriora
Externí odkaz:
https://doaj.org/article/c29edb58bb2f4ed58f9de2506d19afdc
Publikováno v:
Neurobiology of Disease, Vol 2, Iss 2, Pp 97-108 (1995)
The objective of the present experiments was to characterize conditions under which pre-ischaemic hyperglycaemia aggravates brain damage following transient forebrain ischaemia. Specifically, we wished to explore whether accentuated damage is a thres
Externí odkaz:
https://doaj.org/article/f7888fb891874906b36cf5098b2433e1
Publikováno v:
Neurobiology of Disease, Vol 1, Iss 1, Pp 31-41 (1994)
Mechanisms causing gradual recruitment of damaged cells in the penumbra zone around the core of a focal ischaemic lesion may encompass irregularly occurring depolarization waves of the spreading depression (SD) type, each leading to transient loading
Externí odkaz:
https://doaj.org/article/8bd3d23ad6504d40a3bdddccd7b99ce7
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 22:1428-1431
Susceptibility-weighted imaging (SWI) has recently attracted attention for its ability to investigate acute stroke pathophysiology. SWI detects an increased ratio of deoxyhemoglobin to oxyhemoglobin in cerebral venous compartments, which can illustra
Autor:
Bo K. Siesjö
Publikováno v:
Acta Neurologica Scandinavica. 38:121-141